Predicted to be a structural constituent of chromatin. Involved in negative regulation of DNA-templated transcription and negative regulation of cell fate specification. Located in chromatin; condensed chromosome; and nucleus. Is expressed in several structures, including somatic gonad. Orthologous to several human genes including H2AZ2 (H2A.Z variant histone 2).
WB Description
htz-1 encodes the C. elegans ortholog of the H2A.Z histone variant; htz-1 is an essential gene and during development, HTZ-1 functions with the PHA-4/FoxA transcription factor and the MYS-1/TIP60-SSL-1/SWR1 remodeling complex to regulate gene expression during pharyngeal (foregut) organogenesis; a YFP::HTZ-1 fusion protein localizes to pharyngeal gene promoters at the onset of transcription, in a manner that requires PHA-4.