Gene

htz-1

Species
Caenorhabditis elegans
Symbol
htz-1
Name
HisTone variant H2AZ homolog 1
Synonyms
  • CELE_R08C7.3
  • R08C7.3
Biotype
protein coding gene
Automated Description
Predicted to be a structural constituent of chromatin. Involved in negative regulation of DNA-templated transcription and negative regulation of cell fate specification. Located in chromatin; condensed chromosome; and nucleus. Is expressed in several structures, including somatic gonad. Orthologous to several human genes including H2AZ2 (H2A.Z variant histone 2).
WB Description
htz-1 encodes the C. elegans ortholog of the H2A.Z histone variant; htz-1 is an essential gene and during development, HTZ-1 functions with the PHA-4/FoxA transcription factor and the MYS-1/TIP60-SSL-1/SWR1 remodeling complex to regulate gene expression during pharyngeal (foregut) organogenesis; a YFP::HTZ-1 fusion protein localizes to pharyngeal gene promoters at the onset of transcription, in a manner that requires PHA-4.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23430
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
4.4463M4.4464M4.4465M4.4466M4.4467M4.4468M4.4469M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions