Version: 8.0.0Date: Tue Jan 28 2025
Gene
aak-2
- Species
- Caenorhabditis elegans
- Symbol
- aak-2
- Name
- AMP-Activated Kinase 2
- Synonyms
- AMPK
- CELE_T01C8.1
- Biotype
- protein coding gene
- Automated Description
- Enables AMP-activated protein kinase activity. Involved in several processes, including determination of adult lifespan; nematode pharyngeal pumping; and regulation of protein secretion. Located in axon; cytoplasm; and neuronal cell body. Is expressed in several structures, including body wall musculature; excretory cell; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in Huntington's disease; breast cancer; colon cancer; and type 2 diabetes mellitus. Orthologous to human PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1) and PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2).
- WB Description
- aak-2 encodes one of two C. elegans homologs of the catalytic alpha subunit of AMP-activated protein kinases (AMPKs); in C. elegans, aak-2 functions downstream of environmental stressors, energy level signals (AMP:ATP ratio), and daf-2-mediated insulin signaling to positively regulate adult lifespan; in regulating lifespan, aak-2 likely acts in parallel with daf-16/FOXO; aak-2 activity is also required for dauer formation in daf-2 mutant animals at high temperature in a manner independent of the AMP:ATP ratio; in the germline, aak-2 functions downstream of daf-2 and daf-7, and in parallel to par-4 and aak-1, to negatively regulate germline proliferation during dauer development; in vitro, AAK-2 exhibits AMP-enhanced kinase activity against a known AMPK substrate, the SAMS peptide.
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24343
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrX:16796087...16803398 + (7.31 kb)
- Assembly version
- WBcel235
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.