Predicted to enable protein serine/threonine phosphatase activity. Involved in several processes, including amoeboid sperm motility; egg-laying behavior; and male meiosis chromosome segregation. Located in chromatin; cytoplasm; and pseudopodium. Is expressed in IL socket cell; anal sphincter muscle; germ line; intestine; and sperm.
WB Description
gsp-4 encodes an ortholog of protein phosphatase 1 gamma, a Glc7/PP1 phosphatase (HGNC:PPP1CA); GSP-4 is nearly identical to GSP-3, and the two proteins appear to function redundantly during sperm development; GSP-3/4 activity is required for chromosome partitioning during sperm meiosis and for sperm motility, specifically for pseudopod development and a normal rate of pseudopodial treadmilling; in regulating sperm development, GSP-3/4 functions upstream of, and regulates the localization of, the major sperm proteins (MSPs); GSP-3/4 may also play a role in egg laying; GSP-3/4 is expresed at high levels in sperm, with strong localization seen around meiotic and mature sperm DNA.