Gene

gsp-4

Species
Caenorhabditis elegans
Symbol
gsp-4
Name
GLC7 (yeast Glc Seven) like Phosphatase 4
Synonyms
  • CELE_T03F1.5
  • T03F1.5
Biotype
protein coding gene
Automated Description
Predicted to enable protein serine/threonine phosphatase activity. Involved in several processes, including amoeboid sperm motility; egg-laying behavior; and male meiosis chromosome segregation. Located in chromatin; cytoplasm; and pseudopodium. Is expressed in IL socket cell; anal sphincter muscle; germ line; intestine; and sperm.
WB Description
gsp-4 encodes an ortholog of protein phosphatase 1 gamma, a Glc7/PP1 phosphatase (HGNC:PPP1CA); GSP-4 is nearly identical to GSP-3, and the two proteins appear to function redundantly during sperm development; GSP-3/4 activity is required for chromosome partitioning during sperm meiosis and for sperm motility, specifically for pseudopod development and a normal rate of pseudopodial treadmilling; in regulating sperm development, GSP-3/4 functions upstream of, and regulates the localization of, the major sperm proteins (MSPs); GSP-3/4 may also play a role in egg laying; GSP-3/4 is expresed at high levels in sperm, with strong localization seen around meiotic and mature sperm DNA.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11668
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
3.8384M3.8386M3.8388M3.8390M3.8392M3.8394M3.8396M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions