Version: 8.0.0
Date: Tue Jan 28 2025
nmrk-1
Caenorhabditis elegansWB:WBGene00020842
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

nmrk-1

Species
Caenorhabditis elegans
Symbol
nmrk-1
Name
NicotinaMide Riboside Kinase homolog 1
Synonyms
  • CELE_T27A3.6
  • moc-4
Biotype
protein coding gene
Automated Description
Predicted to enable molybdopterin synthase activity. Predicted to be involved in Mo-molybdopterin cofactor biosynthetic process. Predicted to be located in cytoplasm. Predicted to be part of molybdopterin synthase complex. Predicted to be active in cytosol. Used to study molybdenum cofactor deficiency type B. Human ortholog(s) of this gene implicated in molybdenum cofactor deficiency type B. Orthologous to human MOCS2 (molybdenum cofactor synthesis 2).
WB Description
T27A3.6 is orthologous to the human gene Molybdenum cofactor synthesis gene 2 (MOCS2), which encodes molybdenum cofactor synthesis protein 2A and molybdenum cofactor synthesis protein 2B, which dimerize to form molybdopterin synthase.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23404
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            6.1060M6.1062M6.1064M6.1066M6.1068M6.1070M6.1072M6.1074M6.1076M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            nmrk-1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              nmrk-1 role
              nmrk-1 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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