Gene

pck-1

Species
Caenorhabditis elegans
Symbol
pck-1
Name
Phosphoenolypyruvate CarboxyKinase 1
Synonyms
  • CELE_W05G11.6
  • W05G11.6
Biotype
protein coding gene
Automated Description
Predicted to enable manganese ion binding activity and phosphoenolpyruvate carboxykinase (GTP) activity. Predicted to be involved in several processes, including carboxylic acid metabolic process; cellular response to glucose stimulus; and gluconeogenesis. Located in cytosol and striated muscle dense body. Is expressed in several structures, including body wall musculature; preanal ganglion; somatic nervous system; tail ganglion; and in male. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to several human genes including PCK1 (phosphoenolpyruvate carboxykinase 1).
WB Description
pck-1 is one of three C. elegans genes that encode proteins with similarity to phosphoenolpyruvate carboxykinase (PEPCK); by similarity, the products of W05G11.6 are predicted to function in gluconeogenesis.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11561
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Other Sources
None
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            63.0k63.5k64.0k64.5k65.0k65.5k66.0k

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            pck-1 molecule type
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              Genetic Interactions

              pck-1 role
              pck-1 genetic perturbation
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