Gene

atat-2

Species
Caenorhabditis elegans
Symbol
atat-2
Name
Alpha Tubulin AcetylTransferase 2
Synonyms
  • CELE_W06B11.1
  • W06B11.1
Biotype
protein coding gene
Automated Description
Enables tubulin N-acetyltransferase activity. Involved in thigmotaxis. Predicted to be located in microtubule. Is expressed in ciliated neurons and touch receptor neurons. Orthologous to human ATAT1 (alpha tubulin acetyltransferase 1).
WB Description
atat-2 encodes an alpha-tubulin acetyltransferase; atat-2 functions redundantly with its paralog, MEC-17, for acetylation of K40 on MEC-12 alpha-tubulin, an alpha-tubulin enriched in the touch receptor neurons.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12327
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensATAT15 of 9YesNo   
Mus musculusAtat15 of 9YesNo   
Rattus norvegicusAtat14 of 9YesNo   
Xenopus tropicalisatat15 of 9YesNo   
Danio rerioatat16 of 9YesYes   
Drosophila melanogasterlky8 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
mec-17126043284 of 8  

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
axon branching variant
mechanosensation variant
nose touch defective
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
No data available

Alleles and Variants

Genome location
Assembly version
WBcel235
Viewer Help
5.8495M5.8500M5.8505M5.8510M5.8515M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
ok2415allele with one associated variant
deletion
  • splice acceptor variant
Yes
NC_003284.9:g.5850354T>Cvariant
SNP
  • splice region variant
NC_003284.9:g.5850683C>Tvariant
SNP
  • intron variant
NC_003284.9:g.5849815A>Tvariant
SNP
  • intron variant
NC_003284.9:g.5851362T>Cvariant
SNP
  • intron variant
NC_003284.9:g.5850128A>Cvariant
SNP
  • intron variant
NC_003284.9:g.5851345A>Gvariant
SNP
  • intron variant
NC_003284.9:g.5849422C>Tvariant
SNP
  • missense variant
NC_003284.9:g.5850686G>Avariant
SNP
  • intron variant
NC_003284.9:g.5851675G>Avariant
SNP
  • missense variant
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Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
RB1869WB
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Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
5.8495M5.8500M5.8505M5.8510M5.8515MW06B11.1.1 (atat-2)W06B11.4a.1 (hog-1)W06B11.4b.1 (hog-1)

Sequence Details

Transcript: Mode:
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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

2 interactor genes based on 2 annotations
atat-2 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
mec-12Caenorhabditis elegans
protein
  • enzymatic study
PMID:20829795
protein
nrx-1Caenorhabditis elegans
protein
  • proximity labelling technology
PMID:38252619
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Genetic Interactions

No data available