Gene

nol-6

Species
Caenorhabditis elegans
Symbol
nol-6
Name
NucleOLar protein 6
Synonyms
  • CELE_Y51H7C.11
  • rpa-6
Biotype
protein coding gene
Automated Description
Predicted to enable RNA binding activity. Involved in negative regulation of innate immune response. Predicted to be located in condensed nuclear chromosome and nucleolus. Predicted to be part of CURI complex; UTP-C complex; and small-subunit processome. Is expressed in several structures, including anal depressor muscle; intestine; nervous system; pharynx; and reproductive system. Orthologous to human NOL6 (nucleolar protein 6).
WB Description
nol-6 encodes a nucleolar RNA-associated protein (NRAP); in addition to its predicted role in ribosome biogenesis and thus, nucleolar integrity, genetic analysis indicates that nol-6, along with other nucleolar proteins, plays a role in regulation of innate immunity: loss of nol-6 activity via RNAi results in increased resistance to infection by bacterial pathogens in a manner dependent upon cep-1/p53 and sym-1, which encodes a leucine-rich repeat protein, and whose transcription is positively regulated by CEP-1; enhanced resistance of nol-6 mutant animals to P. aeruginosa is also dependent upon DAF-16 and PMK-1.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR17972
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
1.426M1.428M1.430M1.432M1.434M1.436M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions