Gene

eel-1

Species
Caenorhabditis elegans
Symbol
eel-1
Name
Enhancer of EfL-1 mutant phenotype 1
Synonyms
  • CELE_Y67D8C.5
  • Y67D8C.5
Biotype
protein coding gene
Automated Description
Predicted to enable ubiquitin protein ligase activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; hemidesmosome assembly; and signal transduction in response to DNA damage. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including hermaphrodite gonad; intestine; neurons; pharynx; and vulva. Used to study syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Turner type. Orthologous to human HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1).
WB Description
eel-1 encodes a predicted Hect E3 ubiquitin ligase that contains multiple domains of similarity to the mammalian Mcl1 ubiquitin ligase Mule; eel-1 (enhancer of efl-1) was identified in a screen for modifiers of the transcription factor efl-1/E2F which is involved in the generation of SKN-1 protein asymmetry in the early embryo, a process essential for proper embryonic patterning; EEL-1 binds SKN-1 in yeast two-hybrid assays; genetic interaction studies indicate that eel-1 acts redundantly with one or more EFL-1 targets to regulate the spatial and temporal expression of SKN-1, most likely by promoting SKN-1 degradation; eel-1 is also involved in the organization of hemidesmosomes by maintaining proper levels of one of the constituent proteins, LET-805/myotactin (the putative hemidesmosome extracellular matrix receptor).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11254
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
3.034M3.036M3.038M3.040M3.042M3.044M3.046M3.048M3.050M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions