Predicted to enable ubiquitin protein ligase activity. Involved in several processes, including asymmetric protein localization involved in cell fate determination; hemidesmosome assembly; and signal transduction in response to DNA damage. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including hermaphrodite gonad; intestine; neurons; pharynx; and vulva. Used to study syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Turner type. Orthologous to human HUWE1 (HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1).
WB Description
eel-1 encodes a predicted Hect E3 ubiquitin ligase that contains multiple domains of similarity to the mammalian Mcl1 ubiquitin ligase Mule; eel-1 (enhancer of efl-1) was identified in a screen for modifiers of the transcription factor efl-1/E2F which is involved in the generation of SKN-1 protein asymmetry in the early embryo, a process essential for proper embryonic patterning; EEL-1 binds SKN-1 in yeast two-hybrid assays; genetic interaction studies indicate that eel-1 acts redundantly with one or more EFL-1 targets to regulate the spatial and temporal expression of SKN-1, most likely by promoting SKN-1 degradation; eel-1 is also involved in the organization of hemidesmosomes by maintaining proper levels of one of the constituent proteins, LET-805/myotactin (the putative hemidesmosome extracellular matrix receptor).