Predicted to be located in nucleus. Predicted to be active in nucleolus. Orthologous to human AATF (apoptosis antagonizing transcription factor).
WB Description
Y73E7A.2 encodes a protein with similarity to the vertebrate apoptosis antagonizing transcription factor (AATF); in C. elegans, a deletion mutation in Y73E7A.2, tm5125, has been reported to result in lethality and sterility; studies in vertebrates indicate that AATF binds RNA polymerase II and plays a role in transcriptional regulation, cell-cycle progression, checkpoint control, and apoptosis via regulation of p53 expression.