Gene

aatf-1

Species
Caenorhabditis elegans
Symbol
aatf-1
Name
AATF homolog 1
Synonyms
  • CELE_Y73E7A.2
  • Y73E7A.2
Biotype
protein coding gene
Automated Description
Predicted to be located in nucleus. Predicted to be active in nucleolus. Orthologous to human AATF (apoptosis antagonizing transcription factor).
WB Description
Y73E7A.2 encodes a protein with similarity to the vertebrate apoptosis antagonizing transcription factor (AATF); in C. elegans, a deletion mutation in Y73E7A.2, tm5125, has been reported to result in lethality and sterility; studies in vertebrates indicate that AATF binds RNA polymerase II and plays a role in transcriptional regulation, cell-cycle progression, checkpoint control, and apoptosis via regulation of p53 expression.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15565
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
1.6020M1.6025M1.6030M1.6035M1.6040M1.6045M1.6050M1.6055M1.6060M1.6065M1.6070M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions