Gene

homt-1

Species
Caenorhabditis elegans
Symbol
homt-1
Name
Hydroxyindole-O-MethylTransferase homolog 1
Synonyms
  • CELE_Y74C9A.3
  • Y74C9A.3
Biotype
protein coding gene
Automated Description
Predicted to enable N-terminal protein N-methyltransferase activity. Predicted to be involved in N-terminal protein amino acid methylation. Predicted to be active in cytoplasm. Is expressed in PVT and uterus. Orthologous to several human genes including NTMT1 (N-terminal Xaa-Pro-Lys N-methyltransferase 1).
WB Description
homt-1 encodes a putative hydroxyindole-O-methyltransferase orthologous to human C1orf184 and C9orf32; by homology, HOMT-1 is expected to catalyze the conversion of N-acetyl serotonin to melatonin; homt-1 is expressed in the tail neuron PVT, and in uterine cells; since exogenous melatonin slows C. elegans locomotion and enhances slowing by food, Y74C9A.3 may inhibit locomotion.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12753
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
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    Disease Associations

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      Alleles and Variants

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        Transgenic Alleles

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        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            Sequence Details

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            Expression

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            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

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              Genetic Interactions

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