Gene

tyms-1

Species
Caenorhabditis elegans
Symbol
tyms-1
Name
ThYMidylate Synthetase 1
Synonyms
  • CELE_Y110A7A.4
  • cib-1
Biotype
protein coding gene
Automated Description
Enables thymidylate synthase activity. Involved in dTMP biosynthetic process. Predicted to be active in cytosol and mitochondrion. Is expressed in body wall musculature; gonad; nerve ring; and terminal bulb. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; digenic dyskeratosis congenita; gastrointestinal system cancer (multiple); hematologic cancer (multiple); and rheumatoid arthritis. Orthologous to human TYMS (thymidylate synthetase).
WB Description
tyms-1 encodes the C. elegans thymidylate synthase ortholog; by homology, TYMS-1 is predicted to function in dTMP biosynthesis and thus in DNA synthesis; when expressed as a recombinant protein TYMS-1 exhibits thymidylate synthase activity in vitro, and this activity is negatively regulated by tyrosine nitration; analysis of crude C. elegans extracts indicates that thymidylate synthase activity is present in L1, L3, and dauer larval stages, as well as in adult animals.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11548
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
Viewer Help
5.1384M5.1386M5.1388M5.1390M5.1392M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions