Version: 8.0.0
Date: Tue Jan 28 2025
ltah-1.2
Caenorhabditis elegansWB:WBGene00022610
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

ltah-1.2

Species
Caenorhabditis elegans
Symbol
ltah-1.2
Name
LeukoTriene A4 Hydrolase homolog 1.2
Synonyms
  • CELE_ZC416.6
  • ZC416.6
Biotype
protein coding gene
Automated Description
Predicted to enable aminopeptidase activity and epoxide hydrolase activity. Involved in negative regulation of fatty acid transport; regulation of lipid storage; and regulation of peptide transport. Predicted to be active in cytosol. Is expressed in intestine. Orthologous to human LTA4H (leukotriene A4 hydrolase).
WB Description
ZC416.6 encodes a protein with similarity to bifunctional leukotriene A4 hydrolases/aminopeptidases; loss of ZC416.6 activity via RNAi results in decreased intestinal dipeptide transport, increased fat storage, and increased free fatty acid uptake, a phenotype that mimics loss-of-function mutations in the PEPT-1 intestinal peptide transporter; the product of ZC416.6 is predicted to regulate PEPT-1 transporter activity via regulation of the levels of intracellular amino acids and ultimately, via regulation of the amount of PEPT-1 present on intestinal cell membranes; large-scale expression studies indicate that ZC416.6 is expressed in the intestine.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45726
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
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    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
            Viewer Help
            3.6095M3.6100M3.6105M3.6110M3.6115M3.6120M3.6125M3.6130M

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            ltah-1.2 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              ltah-1.2 role
              ltah-1.2 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
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              Phenotype or trait
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