Gene

nhr-253

Species
Caenorhabditis elegans
Symbol
nhr-253
Name
Nuclear Hormone Receptor family 253
Synonyms
  • CELE_ZK6.4
  • ZK6.4
Biotype
protein coding gene
Automated Description
Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in neurons. Human ortholog(s) of this gene implicated in extrahepatic cholestasis; hepatocellular carcinoma; and progressive familial intrahepatic cholestasis 5. Orthologous to human NR1H4 (nuclear receptor subfamily 1 group H member 4) and NR1I3 (nuclear receptor subfamily 1 group I member 3).
WB Description
Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Expressed in ASEL; ASER; and neurons. Human ortholog(s) of this gene implicated in cholestasis (multiple) and liver disease (multiple). Is an ortholog of human NR1H4 (nuclear receptor subfamily 1 group H member 4) and NR1I3 (nuclear receptor subfamily 1 group I member 3).
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45886
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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396.6k396.8k397.0k397.2k397.4k397.6k397.8k398.0k398.2k398.4k398.6k398.8k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions