Gene

swm-1

Species
Caenorhabditis elegans
Symbol
swm-1
Name
Sperm activation Without Mating 1
Synonyms
  • C25E10.9
  • CELE_C25E10.9
Biotype
protein coding gene
Automated Description
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in spermatid development. Located in extracellular space and secretory vesicle. Is expressed in body wall musculature; coelomocyte; reproductive tract; and in male.
WB Description
swm-1 encodes a putative secreted TIL-domain protease inhibitor that, inmales, inhibits unpolarized round spermatids from remodelling themselvesinto motile spermatozoa until their transfer to a hermaphrodite; SWM-1is also required for efficient sperm transfer, and thus for malefertility; SWM-1 is biologically active from spermatogenesis in L4larvae onward into adulthood, and functions non-autonomously, probablybeing expressed in germline; SWM-1-inhibited spermatid activationrequires SPE-8, SPE-12, and SPE-27; SWM-1 is active in hermaphroditesbut is not strongly required for fertility; SWM-1 is paralogous toC25E10.8, ISL-1, and the products of 11 other C. elegans genes; SWM-1and its relatives are collectively similar to other TIL-domain proteaseinhibitors from nematodes, insects, and vertebrates, including theDrosophila melanogaster seminal fluid protein Acp62F; SWM-1 contains twotandem TIL domains, missense mutations of which partially complement oneanother in vivo, and which therefore may inhibit two differentproteases; mutant swm-1 males can trans-activate hermaphroditespermatids by mating, but prematurely remodel their own spermatids,which then generally fail to be transferred to hermaphrodites;sporadically or artificially transferred swm-1 mutant sperm do, however,fertilize hermaphrodite eggs normally.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23259
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
WBcel235
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9.0542M9.0543M9.0544M9.0545M9.0546M9.0547M9.0548M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions