Version: 8.0.0Date: Tue Jan 28 2025
Gene
lin-15B
- Species
- Caenorhabditis elegans
- Symbol
- lin-15B
- Name
- abnormal cell LINeage 15B
- Synonyms
- CELE_ZK662.4
- lin-15
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable DNA binding activity and metal ion binding activity. Involved in negative regulation of Ras protein signal transduction; negative regulation of vulval development; and regulation of cell fate specification. Predicted to be located in nucleus. Is expressed in several structures, including anal region; germ line; head muscle; oocyte; and somatic cell.
- WB Description
- lin-15B encodes a novel protein that contains a THAP domain, a zinc-coordinating, site-specific DNA-binding domain; lin-15B was first identified as a class B synMuv gene that acts redundantly with lin-15A to negatively regulate the outcome of Ras signaling during vulval cell fate specification; subsequently, lin-15B has been shown to also negatively regulate progression through the G1 phase of the cell cycle and RNA-mediated interference (RNAi).
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR22716
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
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Sequence Feature Viewer
- Genome location
- ChrX:15726123...15732025 + (5.90 kb)
- Assembly version
- WBcel235
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