Version: 8.0.0
Date: Tue Jan 28 2025
mrt-1
Caenorhabditis elegansWB:WBGene00045237
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

mrt-1

Species
Caenorhabditis elegans
Symbol
mrt-1
Name
MoRTal germline 1
Synonyms
  • CELE_F39H2.5
  • F39H2.5
Biotype
protein coding gene
Automated Description
Enables 3'-5' exonuclease activity and single-stranded DNA binding activity. Involved in nucleotide-excision repair and telomere maintenance via telomerase. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in dyskeratosis congenita. Orthologous to human DCLRE1B (DNA cross-link repair 1B).
WB Description
mrt-1 encodes a protein that contains an N-terminal domain homologous to the second OB DNA-binding fold of POT1 (Protection Of Telomeres 1)telomere-binding proteins and a C-terminal domain homologous to the SNM1 family nuclease domain; MRT-1 activity is required in vivo for regulation of telomere length and nucleotide excision repair (DNA crosslink repair); in vitro, MRT-1 exhibits 3'-5' exonuclease activity and single-stranded DNA-binding activity.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23240
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          WBcel235
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          mrt-1 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            mrt-1 role
            mrt-1 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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