Gene

lsy-12

Species
Caenorhabditis elegans
Symbol
lsy-12
Name
Laterally SYmmetric (defective in lateral asymmetry) 12
Synonyms
  • CELE_R07B5.9
  • mys-3
Biotype
protein coding gene
Automated Description
Predicted to enable chromatin binding activity; histone H3 acetyltransferase activity; and transcription coregulator activity. Involved in cell fate specification; maintenance of left/right asymmetry; and positive regulation of gene expression. Predicted to be located in chromatin. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Predicted to be active in nucleus.
WB Description
lsy-12 encodes a histone acetyltransferase; lsy-12 is maternally required for developmental differentiation of ASEL neurons from ASERs, with lsy-12 mutants having double ASERs and no ASELs; lsy-12 is also zygotically required for normal vulval development, locomotion, egg-laying, fecundity, health, and viability of gravid hermaphrodites; lsy-12(ot171) hermaphrodites bag prematurely, are sickly, and have mildly protruding vulvae, while other lsy-12 mutants display egg-laying defects, protruding vulvae, or low brood sizes; on the basis of its phenotype, lsy-12 is expected to act in concert with CEH-36, DIE-1, LIN-49, LSY-2, and lsy-6 during the lateral specification of ASER/ASEL.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10615
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

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Other Sources
None
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    Disease Associations

    Cases where the expected disease association was NOT found
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      Alleles and Variants

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        Transgenic Alleles

        Species
        (carrying the transgene)
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            WBcel235
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            9.848M9.850M9.852M9.854M9.856M9.858M

            Sequence Details

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            Expression

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            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            lsy-12 molecule type
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              Genetic Interactions

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