Version: 8.0.0Date: Tue Jan 28 2025
Gene
dlst
- Species
- Xenopus tropicalis
- Symbol
- dlst
- Name
- dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
- Synonyms
- dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
- dlst
- Biotype
- gene
- Automated Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and dihydrolipoyllysine-residue succinyltransferase activity. Predicted to be involved in several processes, including Notch signaling pathway; regulation of transcription by RNA polymerase II; and tricarboxylic acid cycle. Predicted to act upstream of or within L-lysine catabolic process to acetyl-CoA via saccharopine. Predicted to be located in mitochondrial matrix. Predicted to be part of oxoglutarate dehydrogenase complex. Predicted to be active in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase).
- XBXT Description
- Dihydrolipoamide succinyltransferase (2-oxoglutarate dehydrogenase, E2 subunit)https://www.xenbase.org/gene/showgene.do?method=display&geneId=1016309
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- Not Available
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr08:61036602...61052760 + (16.16 kb)
- Assembly version
- XT9.1
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
- None
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.