Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in endoplasmic reticulum unfolded protein response; protein K48-linked ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytosol and endoplasmic reticulum. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 89. Orthologous to human AMFR (autocrine motility factor receptor).