Predicted to enable inositol-1,4,5-trisphosphate 5-phosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in synaptic vesicle endocytosis. Predicted to act upstream of or within phosphatidylinositol dephosphorylation. Predicted to be active in membrane; perinuclear region of cytoplasm; and presynapse. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 20; and developmental and epileptic encephalopathy 53. Orthologous to human SYNJ1 (synaptojanin 1).
XBXT Description
Inositol-1,4,5-triphosphate 5-phosphatase (synaptojanin), INP51/INP52/INP53 family