Version: 8.0.0
Date: Tue Jan 28 2025
idh2
Xenopus tropicalisXenbase:XB-GENEPAGE-976314
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

idh2

Species
Xenopus tropicalis
Symbol
idh2
Name
isocitrate dehydrogenase 2 (NADP+), mitochondrial
Synonyms
  • idh2
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial
Biotype
gene
Automated Description
Predicted to enable isocitrate dehydrogenase (NADP+) activity. Predicted to be involved in NADP metabolic process. Predicted to act upstream of or within glyoxylate cycle; isocitrate metabolic process; and tricarboxylic acid cycle. Predicted to be active in mitochondrion. Is expressed in anatomical system; ectoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; carcinoma (multiple); and lung cancer (multiple). Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2).
XBXT Description
Cross References
Additional Information
Literature

Orthology

Gene tree
Not Available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          XT9.1
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          None
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          idh2 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            idh2 role
            idh2 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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