Version: 8.1.0
Date: Fri Apr 18 2025
metap2b
Danio rerioZFIN:ZDB-GENE-030131-2172
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

metap2b

Species
Danio rerio
Symbol
metap2b
Name
methionyl aminopeptidase 2b
Synonyms
  • metap2
  • wu:fb98h06
Biotype
protein coding gene
Automated Description
Predicted to enable aminopeptidase activity and metalloexopeptidase activity. Acts upstream of or within Wnt signaling pathway; definitive hemopoiesis; and hematopoietic stem cell differentiation. Predicted to be active in cytoplasm. Is expressed in several structures, including digestive system; heart tube; hematopoietic system; pronephric duct; and trunk. Orthologous to human METAP2 (methionyl aminopeptidase 2).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10804
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensMETAP210 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☑
Mus musculusMetap210 of 10YesYes☑ ☑☑☑☑☑☑☑☑ ☑
Rattus norvegicusMetap29 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Xenopus tropicalismetap29 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Drosophila melanogasterund8 of 10YesYes☐ ☑☑☑☑☑☑☑☑ ☐
Caenorhabditis elegansmap-28 of 9YesYes☐ ☑☑☑☑☑☑☑☑  
Caenorhabditis elegansT27A8.34 of 9NoYes☑ ☐☐☐☑☐☑☑☐  
Caenorhabditis elegansF53B6.54 of 9NoYes☑ ☐☐☐☑☐☑☑☐  
Saccharomyces cerevisiae S288CMAP28 of 9YesYes☐ ☑☑☑☑☑☑☑☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
metap2a147090818 of 8☑ ☑☑☑☑☑☑☑ 
pa2g4b233245262 of 8☑ ☐☐☐☐☐☑☐ 
pa2g4a334345242 of 8☑ ☐☐☐☐☐☑☐ 
metap1443033212 of 8☑ ☐☐☐☐☐☑☐ 
metap1d523341252 of 8☑ ☐☐☐☐☐☑☐ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
convergent extension involved in axis elongation disrupted, abnormal
initiator methionyl aminopeptidase activity decreased occurrence, abnormal
intersegmental vessel morphology, abnormal
myeloid cell differentiation process quality, abnormal
non-canonical Wnt signaling pathway disrupted, abnormal
post-anal tail morphogenesis disrupted, abnormal
post-vent region decreased length, abnormal
protein phosphorylation increased occurrence, abnormal
sprouting angiogenesis disrupted, abnormal
vasculogenesis process quality, normal
Showing 1 - 10 of 12 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
No data available

Alleles and Variants

Genome location
Assembly version
GRCz11
Viewer Help
Data currently unavailable; sequence viewer under construction
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
sa37984allele with one associated variant
point mutation
  • stop gained
sa37982allele with one associated variant
point mutation
  • stop gained
Showing 1 - 2 of 2 rows
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View detailed Alleles/Variants information
Download all Alleles/Variants for all genes of the species

Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
WT + MO1-metap2b
has condition:
standard conditions
  • convergent extension involved in axis elongation disrupted, abnormal
  • initiator methionyl aminopeptidase activity decreased occurrence, abnormal
ZFIN
WT + MO1-metap2b + MO1-wnt5b
has condition:
standard conditions
  • convergent extension involved in axis elongation disrupted, abnormal
  • post-anal tail morphogenesis disrupted, abnormal
ZFIN
y1Tg + MO1-metap2b
has condition:
standard conditions
  • intersegmental vessel morphology, abnormal
  • protein phosphorylation increased occurrence, abnormal
ZFIN
Showing 1 - 3 of 3 rows
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Sequence Feature Viewer

Genome location
Assembly version
GRCz11
Viewer Help
Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available