Gene

igf2b

Species
Danio rerio
Symbol
igf2b
Name
insulin-like growth factor 2b
Synonyms
  • fc21h08
  • igf2a
Biotype
protein coding gene
Automated Description
Enables insulin-like growth factor receptor binding activity. Acts upstream of or within several processes, including fin regeneration; somitogenesis; and sprouting angiogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; digestive system; hypochord; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Orthologous to human IGF2 (insulin like growth factor 2).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11454
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
igf2a121269547 of 8  
igf3219745312 of 8  
igf1310465562 of 8  
insb411943282 of 8  
ins59744282 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
angiogenesis disrupted, abnormal
apoptotic process increased occurrence, abnormal
blood circulation disrupted, abnormal
blood decreased fluid flow, abnormal
brain structure, abnormal
bulbus arteriosus morphology, abnormal
convergent extension involved in axis elongation delayed, abnormal
dorsal/ventral axis specification disrupted, abnormal
dorsal/ventral pattern formation disrupted, abnormal
embryo development process quality, normal
Showing 1 - 10 of 35 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
AB + MO1-igf2a + MO3-igf2b
has condition:
standard conditions
  • apoptotic process increased occurrence, abnormal
  • blood circulation disrupted, abnormal
ZFIN
AB + MO3-igf2b
has condition:
standard conditions
  • apoptotic process increased occurrence, abnormal
  • blood circulation disrupted, abnormal
ZFIN
AB/TU + MO1-igf2a + MO1-igf2b + MO2-igf2a + MO2-igf2b + MO4-tp53
has condition:
standard conditions
  • notochord undulate, abnormal
  • somite specification disrupted, abnormal
ZFIN
AB/TU + MO1-igf2b
has condition:
standard conditions
  • convergent extension involved in axis elongation delayed, abnormal
  • dorsal/ventral axis specification disrupted, abnormal
ZFIN
AB/TU + MO1-igf2b + MO2-igf2b
has condition:
standard conditions
  • convergent extension involved in axis elongation delayed, abnormal
  • forebrain morphology, abnormal
ZFIN
AB/TU + MO2-igf2b
has condition:
standard conditions
  • convergent extension involved in axis elongation delayed, abnormal
  • notochord undulate, abnormal
ZFIN
WT + MO4-igf2b
has condition:
physical alteration anatomical structure
  • fin regeneration arrested, abnormal
  • fin regeneration decreased process quality, abnormal
ZFIN
y1Tg + MO1-igf2a + MO3-igf2b
has condition:
standard conditions
  • angiogenesis disrupted, abnormal
  • cranial blood vessel decreased size, abnormal
ZFIN
y1Tg + MO3-igf2b
has condition:
standard conditions
  • angiogenesis disrupted, abnormal
  • vasculogenesis process quality, normal
ZFIN
y7Tg + MO2-igf2b + MO3-igf2b + MO4-tp53
has condition:
standard conditions
  • intersegmental vessel filopodium decreased amount, abnormal
  • intersegmental vessel sprouting angiogenesis disrupted, abnormal
ZFIN
Showing 1 - 10 of 10 rows
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Sequence Feature Viewer

Genome location
Assembly version
GRCz11
Viewer Help
24.040M24.041M24.042M24.043M24.044M24.045M24.046M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available