Gene

kdm5bb

Species
Danio rerio
Symbol
kdm5bb
Name
lysine demethylase 5Bb
Synonyms
  • cb264
  • jarid1bb
Biotype
protein coding gene
Automated Description
Predicted to enable histone H3K4me/H3K4me2/H3K4me3 demethylase activity. Predicted to be involved in chromatin remodeling and regulation of DNA-templated transcription. Predicted to act upstream of or within chromatin organization. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including hindbrain neural plate; musculature system; nervous system; neural tube; and solid lens vesicle. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 65; breast cancer; and high grade glioma. Orthologous to human KDM5B (lysine demethylase 5B).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10694
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensKDM5B10 of 10YesYes  
Mus musculusKdm5b10 of 10YesYes  
Rattus norvegicusKdm5b9 of 9YesYes   
Xenopus tropicaliskdm5b3 of 9YesYes   
Drosophila melanogasterKdm58 of 10YesNo  
Caenorhabditis elegansrbr-29 of 9YesYes   
Saccharomyces cerevisiaeJHD26 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
kdm5ba1155174627 of 8  
kdm5a2170962467 of 8  
kdm5c3166357427 of 8  
kdm4aa4128935203 of 8  
kdm4c5132632203 of 8  
kdm4ab6122034213 of 8  
kdm4b7116835213 of 8  
jarid2a885639233 of 8  
jarid2b984340233 of 8  

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Must provide at least one subject
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
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      Alleles and Variants

      Genome location
      Assembly version
      GRCz11
      Viewer Help
      28.310M28.315M28.320M28.325M28.330M28.335M
      Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCz11
            Viewer Help
            28.310M28.315M28.320M28.325M28.330M28.335Mkdm5bb-201 (kdm5bb)kdm5bb-202 (kdm5bb)kdm5bb-203 (kdm5bb)kdm5bb-204 (kdm5bb)kdm5bb-205 (kdm5bb)

            Sequence Details

            Transcript: Mode:

            Expression

            Primary Sources
            Other Sources
            Must provide at least one subject
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            kdm5bb molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              kdm5bb role
              kdm5bb genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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