Gene

msh2

Species
Danio rerio
Symbol
msh2
Name
mutS homolog 2 (E. coli)
Synonyms
  • wu:fc06b02
  • wu:fc13e09
Biotype
protein coding gene
Automated Description
Enables guanine/thymine mispair binding activity. Acts upstream of or within maintenance of DNA repeat elements. Predicted to be part of MutSalpha complex. Predicted to be active in nucleus. Is expressed in alar plate midbrain region; immature eye; nervous system; and pharyngeal arch 3-7 skeleton. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome (multiple); gastrointestinal system cancer (multiple); lung cancer (multiple); mismatch repair cancer syndrome; and transitional cell carcinoma. Orthologous to human MSH2 (mutS homolog 2).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11361
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCz11
Viewer Help
24.908M24.910M24.912M24.914M24.916M24.918M24.920M24.922M24.924M24.926M24.928M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions