Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within regulation of nervous system development and regulation of neuron apoptotic process. Predicted to be active in nucleus. Predicted to colocalize with mitochondrial matrix. Is expressed in several structures, including brain; digestive system; eye; pericardial region; and pleuroperitoneal region. Orthologous to human FOXO3 (forkhead box O3).