Gene

si:dkey-51d8.1

Species
Danio rerio
Symbol
si:dkey-51d8.1
Name
si:dkey-51d8.1
Synonyms
None
Biotype
protein coding gene
Automated Description
Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome (multiple); and urticaria. Orthologous to several human genes including NLRP12 (NLR family pyrin domain containing 12); NLRP13 (NLR family pyrin domain containing 13); and NLRP14 (NLR family pyrin domain containing 14).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24106
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensNLRP95 of 10YesNo  
Homo sapiensNLRP45 of 10YesNo  
Homo sapiensNLRP145 of 10YesNo  
Homo sapiensNLRP135 of 10YesNo  
Homo sapiensNLRP25 of 10YesNo  
Homo sapiensNLRP35 of 10YesNo  
Homo sapiensNLRP125 of 10YesNo  
Mus musculusNlrp145 of 10YesNo  
Mus musculusNlrp4e5 of 10YesNo  
Mus musculusNlrp4a5 of 10YesNo  
Mus musculusNlrp35 of 10YesNo  
Mus musculusNlrp125 of 10YesNo  
Rattus norvegicusNlrp125 of 9YesNo   
Rattus norvegicusNlrp145 of 9YesNo   
Rattus norvegicusNlrp4a5 of 9YesNo   
Rattus norvegicusNlrp35 of 9YesNo   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
si:ch211-196h24.116 of 8  
si:dkey-178j11.525 of 8  
si:ch211-207e19.225 of 8  
si:dkey-151g22.125 of 8  
si:ch211-238e22.825 of 8  
si:dkey-11n14.125 of 8  
si:dkeyp-100h4.125 of 8  
si:dkey-165e24.125 of 8  
si:ch211-232d10.125 of 8  
si:ch73-50f9.425 of 8  
si:ch211-76m11.825 of 8  
si:ch211-133h13.125 of 8  
si:dkey-82i20.125 of 8  
si:dkey-29j8.125 of 8  
si:ch211-76m11.325 of 8  
si:ch211-237a4.225 of 8  
si:ch211-227p7.525 of 8  
si:dkey-264f17.225 of 8  
si:rp71-7l19.225 of 8  
si:cabz01069012.225 of 8  
si:dkey-165o8.125 of 8  
si:ch211-205a14.125 of 8  
si:ch211-227e10.625 of 8  
zgc:17418025 of 8  
si:dkey-27n6.125 of 8  
zgc:11017125 of 8  
si:ch211-197e7.125 of 8  
si:dkey-71l4.425 of 8  
si:ch211-233m11.134 of 8  
si:ch211-203c5.334 of 8  
si:dkey-13n15.1134 of 8  
si:zfos-364h11.134 of 8  
si:ch211-201o1.134 of 8  
zgc:17370934 of 8  
si:ch211-250k18.734 of 8  
si:dkey-124l13.134 of 8  
nlrp12l34 of 8  
si:dkey-26m3.334 of 8  
nlrc734 of 8  
si:dkeyp-35e5.534 of 8  
si:ch211-271g18.134 of 8  
si:dkey-61p9.934 of 8  
si:ch211-22k7.934 of 8  
nlrc3l234 of 8  
si:dkey-233e3.234 of 8  
si:ch211-238e22.734 of 8  
si:dkey-193i10.434 of 8  
si:dkeyp-123a12.234 of 8  
si:ch211-214b16.334 of 8  
si:dkey-121n8.734 of 8  
si:ch211-213a13.934 of 8  
si:ch211-114l13.1343 of 8  
si:dkeyp-77c4.143 of 8  
si:ch211-171l17.443 of 8  
si:dkey-7i4.143 of 8  
si:ch211-15j1.443 of 8  
si:dkey-222h21.1043 of 8  
si:ch73-236c18.243 of 8  
nlrc1143 of 8  
si:ch211-191a16.243 of 8  
si:dkey-118k5.343 of 8  
si:ch211-194e1.743 of 8  
zgc:17494443 of 8  
si:ch211-11p18.643 of 8  
si:ch211-236p5.343 of 8  
nlrc1043 of 8  
si:dkey-222h21.1143 of 8  
si:ch211-278p9.143 of 8  
si:ch211-15j1.343 of 8  
si:dkey-222h21.843 of 8  
si:ch211-187g4.143 of 8  
nlrc843 of 8  
si:dkey-71l4.343 of 8  
si:dkey-222h21.243 of 8  
si:ch211-196h16.543 of 8  
si:ch211-15j1.143 of 8  
si:dkey-59l11.1043 of 8  
nlrc643 of 8  
si:dkey-222h21.743 of 8  
si:ch73-168d20.143 of 8  
si:ch211-114l13.143 of 8  
si:dkeyp-4c4.143 of 8  
si:ch211-226o13.143 of 8  
si:dkey-222h21.143 of 8  
si:ch211-181d7.143 of 8  
si:ch211-236p5.243 of 8  
si:ch73-236c18.543 of 8  
si:ch211-149a19.343 of 8  
si:ch211-15j1.543 of 8  
zmp:000000102043 of 8  
si:ch211-255g12.843 of 8  
zgc:19490643 of 8  
si:ch211-194e1.943 of 8  
si:ch73-24k9.243 of 8  
si:dkey-222h21.343 of 8  
nlrp343 of 8  
si:ch73-236c18.743 of 8  
si:dkey-222h21.943 of 8  
si:dkey-222h21.552 of 8  
si:ch211-196h16.452 of 8  
si:ch211-214b16.252 of 8  
nlrc3l52 of 8  
si:ch211-191a16.552 of 8  
nlrx152 of 8  
nlrc952 of 8  
si:ch211-256e16.1152 of 8  
nlrc552 of 8  
si:dkey-23k10.352 of 8  
si:dkey-23k10.252 of 8  
nlrp1652 of 8  
si:ch73-233m11.252 of 8  

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
None
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
Homo sapiensNLRP3
is implicated inautosomal dominant nonsyndromic deafness 34
  • IAGP
    Homo sapiensNLRP3
    is implicated inCINCA Syndrome
    • IAGP
      Homo sapiensNLRP3
      is implicated infamilial cold autoinflammatory syndrome 1
      • IAGP
        Homo sapiensNLRP12
        is implicated infamilial cold autoinflammatory syndrome 2
        • IAGP
          Homo sapiensNLRP3
          is implicated inMuckle-Wells syndrome
          • IAGP
            Homo sapiensNLRP3
            is implicated in
            • susceptibility to
            urticaria
            • IAGP
              Rattus norvegicusNlrp3
              is marker foralcoholic hepatitis
              • IEP
                Rattus norvegicusNlrp3
                is marker for
                • severity of
                myocardial infarction
                • IEP
                  Mus musculusNlrp3
                  is implicated inCINCA Syndrome
                  • TAS
                    Mus musculusNlrp3
                    is implicated infamilial cold autoinflammatory syndrome 1
                    • TAS
                      Showing 1 - 10 of 11 rows
                      per page

                      Transgenic Alleles

                      No data available

                      Models

                      No data available

                      Sequence Feature Viewer

                      Genome location
                      Assembly version
                      GRCz11
                      Viewer Help
                      45.000M45.005M45.010M45.015M45.020M45.025Msi:dkey-51d8.1-202 (si:dkey-51d8.1)

                      Sequence Details

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                      Expression

                      Primary Sources
                      None
                      Other Sources
                      all annotationsall anatomical structuresalimentary part of gastrointestinal systemchemosensory systemcirculatory systemendocrine systemexocrine systemhemolymphoid systemhepatobiliary systemintegumental systemmechanosensory systemmusculoskeletal systemnervous systemrenal systemreproductive systemrespiratory systemsensory systemvestibulo-auditory systemvisual systemendodermectodermmesodermmesenchymeadipose tissueappendageentire extraembryonic componentimaginal precursorpharyngeal archotherall stagesembryo stagepost embryonic, pre-adultpost-juvenile adult stageall cellular componentsextracellular regionplasma membranesynapsecell junctioncell projectioncytoplasmic vesicleendosomevacuolegolgi apparatusendoplasmic reticulumcytosolmitochondrionnucleuschromosomecytoskeletonprotein-containing complexother locations
                      si:dkey-51d8.1 (Dre)
                      Nlrp14 (Mmu)
                      Nlrp3 (Mmu)
                      Nlrp4a (Mmu)
                      Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

                      Molecular Interactions

                      No data available

                      Genetic Interactions

                      No data available