Gene

dlk2

Species
Danio rerio
Symbol
dlk2
Name
delta-like 2 homolog (Drosophila)
Synonyms
  • si:ch211-117c8.3
Biotype
protein coding gene
Automated Description
Predicted to enable calcium ion binding activity. Acts upstream of or within negative regulation of Notch signaling pathway; negative regulation of angiogenesis; and vasculature development. Predicted to be located in membrane. Orthologous to human DLK2 (delta like non-canonical Notch ligand 2).
ZFIN Description
Not Available
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR44714
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensDLK210 of 10YesYes  
Mus musculusDlk210 of 10YesYes  
Rattus norvegicusDlk29 of 9YesYes   
Xenopus tropicalisdlk23 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
dlb142644342 of 8  
dld242146332 of 8  
dlc338649352 of 8  
dla441245332 of 8  
dll4534647362 of 8  
jag1b630547372 of 8  
jag1a729447382 of 8  
jag2a830444342 of 8  
si:ch73-281k2.5925945302 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
subintestinal vein sprouting angiogenesis increased occurrence, abnormal
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
GRCz11
Viewer Help
4.206M4.207M4.208M4.209M4.210M4.211M4.212M4.213M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
sa17360allele with one associated variant
point mutation
  • splice acceptor variant
sa45479allele with one associated variant
point mutation
  • splice donor variant
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Transgenic Alleles

No data available

Models

Model name
Experimental condition
Associated Human Diseases
Associated Phenotypes
Modifier
Source
y1Tg + MO1-dlk2
has condition:
standard conditions
  • subintestinal vein sprouting angiogenesis increased occurrence, abnormal
ZFIN
Showing 1 - 1 of 1 rows
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Sequence Feature Viewer

Genome location
Assembly version
GRCz11
Viewer Help
4.206M4.207M4.208M4.209M4.210M4.211M4.212M4.213Mdlk2-201 (dlk2)

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

No data available

Genetic Interactions

No data available