Version: 8.1.0Date: Fri Apr 18 2025
Gene
trpc4a
- Species
- Danio rerio
- Symbol
- trpc4a
- Name
- transient receptor potential cation channel, subfamily C, member 4a
- Synonyms
- si:dkey-109i21.3
- trpc4b
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable inositol 1,4,5 trisphosphate binding activity and store-operated calcium channel activity. Predicted to be involved in calcium ion transmembrane transport and regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within calcium ion transport and monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of cation channel complex. Predicted to be active in plasma membrane. Is expressed in nervous system. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human TRPC4 (transient receptor potential cation channel subfamily C member 4).
- ZFIN Description
- Not Available
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- Not Available
Stringency:
Additional filters to further constrain the results:
| Species | Gene symbol | Count | Best | Best reverse | Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN |
|---|---|---|---|---|---|
| Homo sapiens | TRPC4 | 5 of 10 | Yes | No | ☑ ☐☐☐☑☐☑☑☐ ☑ |
| Mus musculus | Trpc4 | 5 of 10 | Yes | No | ☑ ☐☐☐☑☐☑☑☐ ☑ |
| Rattus norvegicus | Trpc4 | 4 of 9 | Yes | No | ☑ ☐☐☐☑☐☑☑☐ |
| Xenopus tropicalis | trpc4 | 5 of 9 | Yes | No | ☑ ☐☐☐☑☑☑☑☐ |
| Drosophila melanogaster | Trpγ | 9 of 10 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ ☐ |
| Drosophila melanogaster | trp | 8 of 10 | No | Yes | ☑ ☑☑☐☑☑☑☑☑ ☐ |
| Drosophila melanogaster | trpl | 7 of 10 | No | Yes | ☑ ☑☑☐☑☑☐☑☑ ☐ |
| Caenorhabditis elegans | trp-2 | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
| Saccharomyces cerevisiae S288C | YVC1 | 3 of 9 | Yes | Yes | ☐ ☐☑☐☐☑☐☑☐ |
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Paralogy
| Gene symbol | Rank | Alignment Length (aa) | Similarity % | Identity % | Method Count | Method Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD |
|---|---|---|---|---|---|---|
| trpc4b | 1 | 944 | 82 | 75 | 7 of 8 | ☑ ☑☐☑☑☑☑☑ |
| trpc5a | 2 | 909 | 76 | 65 | 7 of 8 | ☑ ☑☐☑☑☑☑☑ |
| trpc1 | 3 | 799 | 65 | 45 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| trpc2b | 4 | 978 | 48 | 32 | 4 of 8 | ☑ ☐☐☑☐☑☑☐ |
| trpc7a | 5 | 854 | 55 | 37 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| trpc6b | 6 | 790 | 56 | 40 | 4 of 8 | ☑ ☐☐☑☐☑☑☐ |
| trpc6a | 7 | 791 | 57 | 40 | 3 of 8 | ☑ ☐☐☐☐☑☑☐ |
| trpc3 | 8 | 856 | 55 | 38 | 2 of 8 | ☐ ☐☐☐☐☑☑☐ |
| trpc7b | 9 | 833 | 56 | 38 | 2 of 8 | ☐ ☐☐☐☐☑☑☐ |
| trpc2a | 10 | 894 | 50 | 32 | 4 of 8 | ☑ ☐☐☑☐☑☑☐ |
Disease Associations
Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species | Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
|---|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | ||||||||
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Alleles and Variants
- Genome location
- Chr10:25829262...25860102 (30.84 kb)
- Assembly version
- GRCz11
- Viewer Help
Data currently unavailable; sequence viewer under construction
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
|---|---|---|---|---|---|---|---|
| sa30939 | allele with one associated variant | point mutation
| |||||
| sa24873 | allele with one associated variant | point mutation
| |||||
| sa9768 | allele with one associated variant | point mutation
| |||||
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Sequence Feature Viewer
- Genome location
- Chr10:25829262...25860102 (30.84 kb)
- Assembly version
- GRCz11
- Viewer Help
Data currently unavailable; sequence viewer under construction