Version: 8.1.0Date: Fri Apr 18 2025
Gene Molecular Function: ubiquitin-like protein binding
Prkn
(Mus musculus)Gene
Name: parkin RBR E3 ubiquitin protein ligase
Synonyms: PRKN, Parkinson disease (autosomal recessive, juvenile) 2, parkin, Park2, Parkin, Park
Source: MGI:1355296
Biotype: protein coding gene
HSPB1
(Homo sapiens)Gene
Name: heat shock protein family B (small) member 1
Synonyms: epididymis secretory protein Li 102, HEL-S-102, HMND3, heat shock protein beta-1, HMN2B, heat shock 27kD protein 1, Hsp25, putative heat shock protein family B member 1 isoform, CMT2F, heat shock 27kDa protein 1, estrogen-regulated 24 kDa protein, SRP27, stress-responsive protein 27, heat shock 27 kDa protein, HSP 27, heat shock protein family B member 1, HS.76067, HSP28, HSP27, DKFZp586P1322, 28 kDa heat shock protein
Source: HGNC:5246
Biotype: protein coding gene
MDM2
(Homo sapiens)Gene
Name: MDM2 proto-oncogene
Synonyms: oncoprotein Mdm2, HDMX, MDM2 proto-oncogene, E3 ubiquitin protein ligase, MGC71221, Mdm2, p53 E3 ubiquitin protein ligase homolog, ACTFS, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein, HDM2 transcript variant MYO-18, MGC5370, hdm2, HDM2 transcript variant MYO-32, HDM2 transcript variant MYO-24, HDM2 transcript variant MYO-4, HDM2 transcript variant MYO-25, ubiquitin-protein ligase E3 Mdm2, MDM2 oncogene, E3 ubiquitin protein ligase, MDM2 variant FB28, double minute 2, human homolog of, p53-binding protein, HDM2 transcript variant MYO-1, HDM2 transcript variant MYO-26, Mdm2 p53 binding protein homolog, HDM2 transcript variant MYO-20, MDM2 variant FB30, E3 ubiquitin-protein ligase Mdm2, double minute 2, human homolog of, LSKB
Source: HGNC:6973
Biotype: protein coding gene
SPRTN
(Homo sapiens)Gene
Name: SprT-like N-terminal domain
Synonyms: DDDL1880, DVC1, C1orf124, Spartan, DNA damage-targeting VCP (p97) adaptor, protein with SprT-like domain at the N terminus, DKFZp547N043, zinc finger RAD18 domain-containing protein C1orf124, RJALS, DNA damage protein targeting VCP, RP5-876B10.3, dJ876B10.3, SprT-like domain at the N terminus, sprT-like domain-containing protein Spartan, DNA-dependent metalloprotease SPRTN, PRO4323
Source: HGNC:25356
Biotype: protein coding gene
RSP5
(Saccharomyces cerevisiae)Gene
Name: Reverses Spt- Phenotype
Synonyms: UBY1, MUT2, HPG1, SMM1, YER125W, MDP1, NPI1
Source: SGD:S000000927
Biotype: protein coding gene
MARK4
(Homo sapiens)Gene
Name: microtubule affinity regulating kinase 4
Synonyms: PAR-1D, Nbla00650, KIAA1860, MARKL1L, MARKL1, MAP/microtubule affinity-regulating kinase-like 1, FLJ12177, MARK4 serine/threonine protein kinase, MAP/microtubule affinity-regulating kinase 4, MARK4S, MAP/microtubule affinity-regulating kinase like 1, MARK4L, putative protein product of Nbla00650, FLJ90097
Source: HGNC:13538
Biotype: protein coding gene
CDC48
(Saccharomyces cerevisiae)Gene
Name: Cell Division Cycle
Synonyms: YDL126C
Source: SGD:S000002284
Biotype: protein coding gene
FBXW7
(Homo sapiens)Gene
Name: F-box and WD repeat domain containing 7
Synonyms: homolog of C elegans sel-10, FBX30, hCdc4, SEL-10, F-box protein SEL-10, F-box protein FBW7, archipelago homolog, F-box protein FBX30, F-box/WD repeat-containing protein 7, FBW6, FBW7, DEDHIL, FBXW6, F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila), AGO, SEL10, CDC4, F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase, FBXO30, hAgo, FLJ16457, archipelago, Drosophila, homolog of, F-box and WD-40 domain-containing protein 7, archipelago, DKFZp686F23254
Source: HGNC:16712
Biotype: protein coding gene
PRKN
(Homo sapiens)Gene
Name: parkin RBR E3 ubiquitin protein ligase
Synonyms: Parkinson disease (autosomal recessive, juvenile) 2, parkin, PDJ, parkinson disease protein 2, LPRS2, parkinson protein 2, E3 ubiquitin protein ligase (parkin), E3 ubiquitin ligase, AR-JP, parkin 2, parkinson juvenile disease protein 2, PARK2, E3 ubiquitin-protein ligase parkin, parkinson protein 2 E3 ubiquitin protein ligase
Source: HGNC:8607
Biotype: protein coding gene
Rad23b
(Mus musculus)Gene
Name: RAD23 homolog B, nucleotide excision repair protein
Synonyms: AV001138, mHR23B, RIKEN cDNA 0610007D13 gene, 0610007D13Rik, expressed sequence AV001138
Source: MGI:105128
Biotype: protein coding gene
CXCR4
(Homo sapiens)Gene
Name: C-X-C motif chemokine receptor 4
Synonyms: C-X-C chemokine receptor type 4, CXCR-4, lipopolysaccharide-associated protein 3, NPYY3R, HSY3RR, WHIMS, CD184 antigen, stromal cell-derived factor 1 receptor, FB22, LPS-associated protein 3, WHIM, NPYRL, CD184, chemokine receptor (lcr1), NPY3R, HM89, CXC-R4, SDF-1 receptor, LAP-3, chemokine receptor, leukocyte-derived seven-transmembrane-domain receptor, D2S201E, leukocyte-derived seven transmembrane domain receptor, LCR1, chemokine (C-X-C motif) receptor 4, LESTR, neuropeptide Y3 receptor, seven-transmembrane-segment receptor, spleen, LAP3, seven transmembrane helix receptor, neuropeptide Y receptor Y3, fusin, WHIMS1, NPYR
Source: HGNC:2561
Biotype: protein coding gene
Top2a
(Mus musculus)Gene
Name: topoisomerase (DNA) II alpha
Synonyms: DNA Topoisomerase II alpha, Top-2, topoisomerase (DNA) II
Source: MGI:98790
Biotype: protein coding gene
Cxcr4
(Mus musculus)Gene
Name: C-X-C motif chemokine receptor 4
Synonyms: b2b220Clo, CD184, PB-CKR, Cmkar4, chemokine (C-X-C) receptor 4, Sdf1r, Mutant line 220, fusin
Source: MGI:109563
Biotype: protein coding gene
RNF8
(Homo sapiens)Gene
Name: ring finger protein 8
Synonyms: ring finger protein (C3HC4 type) 8, FLJ12013, KIAA0646, UBC13/UEV-interacting ring finger protein, hRNF8, ring finger protein 8, E3 ubiquitin protein ligase, E3 ubiquitin-protein ligase RNF8, RING-type E3 ubiquitin transferase RNF8, C3HC4-type zinc finger protein
Source: HGNC:10071
Biotype: protein coding gene
NOD2
(Homo sapiens)Gene
Name: nucleotide binding oligomerization domain containing 2
Synonyms: BLAU, CD, caspase recruitment domain protein 15, NOD2B, caspase recruitment domain family, member 15, IBD1, YAOS, NOD-like receptor C2, ACUG, PSORAS1, nucleotide-binding oligomerization domain-containing protein 2, NLRC2, NLR family, CARD domain containing 2, BLAUS, nucleotide-binding oligomerization domain containing 2, caspase recruitment domain-containing protein 15, inflammatory bowel disease protein 1, Inflammatory bowel disease-1 (Crohn disease), CARD15, nucleotide-binding oligomerization domain 2, nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2, CLR16.3
Source: HGNC:5331
Biotype: protein coding gene
FAF2
(Homo sapiens)Gene
Name: Fas associated factor family member 2
Synonyms: KIAA0887, UBXD8, UBXN3B, UBX domain-containing protein 3B, UBX domain-containing protein 8, expressed in T-cells and eosinophils in atopic dermatitis, ETEA, FAS-associated factor 2, UBX domain protein 3B, UBX domain containing 8
Source: HGNC:24666
Biotype: protein coding gene
UBXN7
(Homo sapiens)Gene
Name: UBX domain protein 7
Synonyms: UBXD7, KIAA0794, UBX domain-containing protein 7, UBX domain containing 7
Source: HGNC:29119
Biotype: protein coding gene
POL2
(Saccharomyces cerevisiae)Gene
Name: POLymerase
Synonyms: DUN2, Pol ε, YNL262W
Source: SGD:S000005206
Biotype: protein coding gene
TOP2A
(Homo sapiens)Gene
Name: DNA topoisomerase II alpha
Synonyms: DNA topoisomerase II, 170 kD, DNA topoisomerase 2-alpha, topoisomerase (DNA) II alpha 170kDa, DNA topoisomerase (ATP-hydrolyzing), TOPIIA, TOP2, TP2A, topoisomerase (DNA) II alpha, DNA gyrase, TOP2alpha, DNA topoisomerase II, alpha isozyme
Source: HGNC:11989
Biotype: protein coding gene
Faf2
(Drosophila melanogaster)Gene
Name: Fas-associated factor 2
Synonyms: Ubxd8, GT#49, FFAF, Faf2, Fly Fas-associated factor, UBX domain 8 like, CG10372, Faf, Fas-associated factor
Source: FB:FBgn0025608
Biotype: protein coding gene
MAP3K7
(Homo sapiens)Gene
Name: mitogen-activated protein kinase kinase kinase 7
Synonyms: MEKK7, TGF1a, TAK1, TGF-beta-activated kinase 1, FMD2, TGF-beta activated kinase 1, CSCF, transforming growth factor-beta-activated kinase 1
Source: HGNC:6859
Biotype: protein coding gene
SMARCAD1
(Homo sapiens)Gene
Name: SNF2 related chromatin remodeling ATPase with DExD box 1
Synonyms: SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1, HEL1, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1, ATP-dependent helicase 1, KIAA1122, ADERM, DKFZp762K2015, TYS, HRZ, hHEL1, ETL1, BASNS, sclerotylosis
Source: HGNC:18398
Biotype: protein coding gene
SQSTM1
(Homo sapiens)Gene
Name: sequestosome 1
Synonyms: PDB3, OSIL, oxidative stress induced like, EBI3-associated protein of 60 kDa, phosphotyrosine independent ligand for the Lck SH2 domain p62, p62B, autophagy receptor p62, FTDALS3, p60, p62, DMRV, EBIAP, phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, NADGP, sequestosome-1, ubiquitin-binding protein p62, A170, ZIP3, EBI3-associated protein p60
Source: HGNC:11280
Biotype: protein coding gene
IKBKG
(Homo sapiens)Gene
Name: inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
Synonyms: Fip3p, ikB kinase subunit gamma, FIP3, NFkappaB essential modulator, ZC2HC9, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, IKKAP1, IKK-gamma, incontinentia pigmenti, IKKG, I-kappa-B kinase subunit gamma, NF-kappa-B essential modulator, incontinentia pigmenti 1 (sporadic, associated with X chromosome rearrangements), AMCBX1, inhibitor of nuclear factor kappa B kinase subunit gamma, IP, IMD33, NF-kappa-B essential modifier, incontinentia pigmenti 2 (familial, male-lethal type), IP2, IP1, FIP-3, EDAID1, inhibitor of nuclear factor kappa-B kinase subunit gamma, IkB kinase gamma subunit, IPD2, ikB kinase-associated protein 1, NEMO, 14.7K (adenovirus E3 protein) interacting protein 3, SAIDX
Source: HGNC:5961
Biotype: protein coding gene
JARID2
(Homo sapiens)Gene
Name: jumonji and AT-rich interaction domain containing 2
Synonyms: DIDDF, protein Jumonji, JMJ, jumonji homolog, jumonji, AT rich interactive domain 2, jumonji/ARID domain-containing protein 2, jumonji-like protein
Source: HGNC:6196
Biotype: protein coding gene
UBE2N
(Homo sapiens)Gene
Name: ubiquitin conjugating enzyme E2 N
Synonyms: epididymis secretory protein Li 71, ubiquitin conjugating enzyme E2N, HEL-S-71, ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast), UbcH13, bendless-like ubiquitin-conjugating enzyme, yeast UBC13 homolog, E2 ubiquitin-conjugating enzyme N, UbcH-ben, ubiquitin-protein ligase N, ubiquitin carrier protein N, UBC13, MGC8489, ubiquitin-conjugating enzyme E2 N, MGC131857, ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13), UBCHBEN, bendless-like ubiquitin conjugating enzyme
Source: HGNC:12492
Biotype: protein coding gene
Map3k7
(Rattus norvegicus)Gene
Name: mitogen activated protein kinase kinase kinase 7
Synonyms: mitogen-activated protein kinase kinase kinase 7-like, Tak1, TGF-beta activated kinase 1, LOC100910771, mitogen-activated protein kinase kinase kinase 7
Source: RGD:1309438
Biotype: protein coding gene
DDI2
(Homo sapiens)Gene
Name: DNA damage inducible 1 homolog 2
Synonyms: DDI1, DNA-damage inducible 1, homolog 2, DNA-damage inducible protein 2 (DDI2), DNA-damage inducible 1 homolog 2, MGC14844, RP4-680D5.5, protein DDI1 homolog 2
Source: HGNC:24578
Biotype: protein coding gene
SLA1
(Saccharomyces cerevisiae)Gene
Name: Synthetic Lethal with ABP1
Synonyms: YBL007C
Source: SGD:S000000103
Biotype: protein coding gene
DEF1
(Saccharomyces cerevisiae)Gene
Name: RNAPII DEgradation Factor
Synonyms: VID31, YKL054C
Source: SGD:S000001537
Biotype: protein coding gene
Smad3
(Mus musculus)Gene
Name: SMAD family member 3
Synonyms: mad3, Madh3, AU022421, expressed sequence AU022421, Smad 3
Source: MGI:1201674
Biotype: protein coding gene
UBX2
(Saccharomyces cerevisiae)Gene
Name: UBiquitin regulatory X
Synonyms: SEL1, YML013W
Source: SGD:S000004475
Biotype: protein coding gene
COP1
(Saccharomyces cerevisiae)Gene
Name: COat Protein
Synonyms: SEC33, RET1, YDL145C, SOO1
Source: SGD:S000002304
Biotype: protein coding gene
Nedd4
(Rattus norvegicus)Gene
Name: NEDD4 E3 ubiquitin protein ligase
Synonyms: E3 ubiquitin-protein ligase NEDD4, neural precursor cell expressed, developmentally down-regulated gene 4A, neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase, Nedd4a, HECT-type E3 ubiquitin transferase NEDD4, Neural precursor cell expressed developmentally down-regulated gene 4, neural precursor cell expressed, developmentally down-regulated 4, Neural precursor cell expressed, developmentally down-regulated gene 4
Source: RGD:3157
Biotype: protein coding gene
Sqstm1
(Mus musculus)Gene
Name: sequestosome 1
Synonyms: ZIP, Osi, oxidative stress induced, STAP, A170, ZIP3, OSF-6, p62
Source: MGI:107931
Biotype: protein coding gene
RAD23
(Saccharomyces cerevisiae)Gene
Name: RADiation sensitive
Synonyms: YEL037C
Source: SGD:S000000763
Biotype: protein coding gene
SLX5
(Saccharomyces cerevisiae)Gene
Name: Synthetic Lethal of unknown [X] function
Synonyms: ULS2, HEX3, YDL013W
Source: SGD:S000002171
Biotype: protein coding gene
ARC40
(Saccharomyces cerevisiae)Gene
Name: ARp2/3 Complex subunit
Synonyms: YBR234C
Source: SGD:S000000438
Biotype: protein coding gene
Zcchc12
(Mus musculus)Gene
Name: zinc finger, CCHC domain containing 12
Synonyms: 2810028A01Rik, expressed sequence AV136720, Sizn1, RIKEN cDNA 2810028A01 gene, AV136720
Source: MGI:1919943
Biotype: protein coding gene
DDI1
(Saccharomyces cerevisiae)Gene
Name: DNA Damage Inducible
Synonyms: VSM1, YER143W
Source: SGD:S000000945
Biotype: protein coding gene
TSG101
(Homo sapiens)Gene
Name: tumor susceptibility 101
Synonyms: tumor susceptibility gene 101, TSG10, tumor susceptibility protein, tumor susceptibility gene 10, VPS23, ESCRT-I complex subunit TSG101
Source: HGNC:15971
Biotype: protein coding gene
Plaa
(Mus musculus)Gene
Name: phospholipase A2, activating protein
Synonyms: AU018445, expressed sequence AU018445, expressed sequence AI536418, AI536418, Ufd3, D4Ertd618e, PLA2P, AW208417, expressed sequence AW208417, DNA segment, Chr 4, ERATO Doi 618, expressed, Plap
Source: MGI:104810
Biotype: protein coding gene
UFD1
(Saccharomyces cerevisiae)Gene
Name: Ubiquitin Fusion Degradation protein
Synonyms: YGR048W
Source: SGD:S000003280
Biotype: protein coding gene
Hspb1
(Mus musculus)Gene
Name: heat shock protein 1
Synonyms: heat shock protein, 25 kDa, Hsp25, Hsp27
Source: MGI:96240
Biotype: protein coding gene
Smarcad1
(Mus musculus)Gene
Name: SNF2 related chromatin remodeling ATPase with DExD box 1
Synonyms: expressed sequence AW226546, AW226546, mKIAA1122, Etl1, AV081750, DNA segment, Chr 6, Pasteur Institute 1, D6Pas1, enhancer trap locus 1, expressed sequence AV081750
Source: MGI:95453
Biotype: protein coding gene
HGS
(Homo sapiens)Gene
Name: hepatocyte growth factor-regulated tyrosine kinase substrate
Synonyms: hgf-regulated tyrosine kinase substrate, protein pp110, FLJ11421, ZFYVE8, FLJ39878, HRS, human growth factor-regulated tyrosine kinase substrate, Vps27
Source: HGNC:4897
Biotype: protein coding gene
SWA2
(Saccharomyces cerevisiae)Gene
Name: Synthetic lethal With Arf1
Synonyms: AUX1, YDR320C, BUD24
Source: SGD:S000002728
Biotype: protein coding gene
FBXO7
(Homo sapiens)Gene
Name: F-box protein 7
Synonyms: DKFZp686B08113, PARK15, FBX07, FBX7, PKPS, FBX, F-box only protein 7
Source: HGNC:13586
Biotype: protein coding gene
Hdac6
(Mus musculus)Gene
Name: histone deacetylase 6
Synonyms: Sfc6, scurfy candidate 6, mHDA2
Source: MGI:1333752
Biotype: protein coding gene
HERC2
(Homo sapiens)Gene
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: hect domain and RLD 2, probable E3 ubiquitin-protein ligase HERC2, SHEP1, DKFZp547P028, HECT-type E3 ubiquitin transferase HERC2, D15F37S1, jdf2, MRT38, hect domain and RCC1-like domain-containing protein 2, p528, E3 ubiquitin-protein ligase HERC2, KIAA0393
Source: HGNC:4868
Biotype: protein coding gene