Version: 8.0.0
Date: Tue Jan 28 2025
4,687 results for fig4

FIG4Δ1

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0322830
Genes: FIG4 (Dme)
Synonyms: Not Available
Variant Type: deletion
Molecular Consequence: 5_prime_UTR_variant, start_lost, splice_donor_variant, splice_acceptor_variant, intron_variant
Diseases: amyotrophic lateral sclerosis type 11
Variant Name: Not Available
Symbol: FIG4<Δ1> (Dme)
Gene Synonyms: Fig4...FIG4 ortholog
Genes: FIG4 (Dme)
Symbol: FIG4Δ1

FIG4MB09541

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0218842
Genes: FIG4 (Dme)
Synonyms: Not Available
Variant Type: insertion
Molecular Consequence: 3_prime_UTR_variant
Diseases: Not Available
Variant Name: Not Available
Symbol: FIG4 (Dme)
Gene Synonyms: Fig4...FIG4 ortholog
Genes: FIG4 (Dme)
Symbol: FIG4MB09541

figo-1

(Caenorhabditis elegans)
Gene
Name: FIG4 Ortholog 1
Synonyms: C34B7.2, CELE_C34B7.2
Source: WB:WBGene00007912
Biotype: protein coding gene
Gene Synopsis: Is an ortholog of human FIG4 (FIG4 phosphoinositide 5-phosphatase).
Automated Gene Synopsis: Orthologous to human FIG4 (FIG4 phosphoinositide 5-phosphatase).
Strict Orthology Symbols: FIG4...Fig4...fig4a

Charcot-Marie-Tooth disease type 4J

Disease
Source: DOID:0110184
Definition: A Charcot-Marie-Tooth disease type 4 that has_material_basis_in compound heterozygous mutations in the FIG4 gene on chromosome 6q21.
Genes: fig4.L (Xla)...Fig4 (Rno)...FIG4 (Sce)...Fig4 (Mmu)...FIG4 (Hsa)
Alleles: FIG4 (Dme)...Fig4 (Mmu)

bilateral parasagittal parieto-occipital polymicrogyria

Disease
Source: DOID:0080923
Definition: A polymicrogyria that is characterized by bilateral malformation of cortical development, centered around the parasagittal and mesial aspects of the parietooccipital cortex and that has_material_basis_in homozygous mutation in the FIG4 gene on chromosome 6q21.
Genes: fig4.L (Xla)...Fig4 (Rno)...fig4b (Dre)...FIG4 (Dme)...FIG4 (Sce)

Yunis-Varon syndrome

Disease
Source: DOID:0060589
Definition: A syndrome characterized by skeletal defects, including cleidocranial dysplasia and digital anomalies, and severe neurologic involvement with neuronal loss. Enlarged cytoplasmic vacuoles are found in neurons, muscle, and cartilage. It is usually lethal in infancy and has_material_basis_in homozygous or compound heterozygous mutation in the FIG4 gene on chromosome 6q21.
Genes: fig4.L (Xla)...Fig4 (Rno)...FIG4 (Sce)...Fig4 (Mmu)...FIG4 (Hsa)
Alleles: Fig4 (Mmu)

amyotrophic lateral sclerosis type 11

Disease
Source: DOID:0060202
Definition: An amyotrophic lateral sclerosis that has_material_basis_in mutation in the FIG4 gene on chromosome 6.
Genes: fig4.L (Xla)...Fig4 (Rno)...FIG4 (Sce)...FIG4 (Dme)...Fig4 (Mmu)
Alleles: FIG4<Δ1> (Dme)

phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity

Gene Ontology
Source: GO:0043813
Synonyms:
  • phosphatidylinositol 3,5-bisphosphate 5-phosphatase activity
Branch: molecular function
Genes: FIG4 (Hsa)...FIG4 (Sce)...Fig4 (Mmu)...fig4b (Dre)...FIG4 (Dme)

phosphatidylinositol bisphosphate phosphatase activity

Gene Ontology
Source: GO:0034593
Synonyms:
  • diphosphoinositide phosphatase activity
  • phosphatidyl-inositol-bisphosphate phosphatase activity
Branch: molecular function
Genes: FIG4 (Hsa)...FIG4 (Sce)...Fig4 (Rno)...Fig4 (Mmu)...FIG4 (Dme)

cq35

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-220329-19
Genes: fig4a (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: fig4
Genes: fig4a (Dre)

phosphatidylinositol-4-phosphate phosphatase activity

Gene Ontology
Source: GO:0043812
Synonyms:
  • phosphatidylinositol 4-phosphate phosphatase activity
Branch: molecular function
Genes: FIG4 (Hsa)...Fig4 (Rno)...Fig4 (Mmu)

PAS complex

Gene Ontology
Source: GO:0070772
Synonyms:
  • autophagy-specific phosphatidylinositol 3-kinase complex
Branch: cellular component
Genes: FIG4 (Sce)...FIG4 (Dme)
Definition: In mammals the complex is composed of PIKFYVE, FIG4 and VAC14....In mammals the complex is composed of PIKFYVE, FIG4 and VAC14.

myelin assembly

Gene Ontology
Source: GO:0032288
Synonyms:
  • myelin formation
  • myelin sheath assembly
Branch: biological process
Genes: FIG4 (Hsa)...Fig4 (Rno)...Fig4 (Mmu)

negative regulation of myelination

Gene Ontology
Source: GO:0031642
Synonyms:
  • down regulation of myelination
  • down-regulation of myelination
Branch: biological process
Genes: Fig4 (Mmu)...FIG4 (Hsa)...Fig4 (Rno)

phosphatidylinositol-3-phosphate phosphatase activity

Gene Ontology
Source: GO:0004438
Synonyms:
  • 1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase activity
  • D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase activity
Branch: molecular function
Genes: Fig4 (Mmu)...Fig4 (Rno)...FIG4 (Hsa)

phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity

Gene Ontology
Source: GO:0034485
Synonyms: Not Available
Branch: molecular function
Genes: Fig4 (Mmu)...FIG4 (Hsa)

phosphatidylinositol-3-phosphate biosynthetic process

Gene Ontology
Source: GO:0036092
Synonyms:
  • PI(3)P biosynthesis
  • PtdIns3P biosynthesis
Branch: biological process
Genes: Fig4 (Mmu)...Fig4 (Rno)...FIG4 (Hsa)...FIG4 (Sce)

phosphatidylinositol dephosphorylation

Gene Ontology
Source: GO:0046856
Synonyms:
  • PIP catabolism
  • PtdInsP catabolism
Branch: biological process
Genes: FIG4 (Dme)...fig4a (Dre)...fig4b (Dre)...FIG4 (Sce)...Fig4 (Mmu)

Charcot-Marie-Tooth disease

Disease
Source: DOID:10595
Definition: A neuromuscular disease that is characterized by a slowly progressive degeneration of the muscles of the foot, lower leg, hand and forearm.
Genes: fig4a (Dre)...Fig4 (Rno)...FIG4 (Dme)...FIG4 (Sce)...Fig4 (Mmu)
Alleles: FIG4 (Dme)...FIG4 (Dme)

vacuole organization

Gene Ontology
Source: GO:0007033
Synonyms:
  • vacuolar assembly
  • vacuole biogenesis
Branch: biological process
Genes: Fig4 (Mmu)...Fig4 (Rno)...FIG4 (Hsa)

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

Gene Ontology
Source: GO:0004439
Synonyms:
  • PI(4,5)P2 5-phosphatase activity
  • PtdIns(4,5)P(2) 5-phosphatase activity
Branch: molecular function
Genes: Fig4 (Mmu)...FIG4 (Hsa)

regulation of lysosome organization

Gene Ontology
Source: GO:1905671
Synonyms:
  • regulation of lysosome organisation
  • regulation of lysosome organization and biogenesis
Branch: biological process
Genes: FIG4 (Dme)

phosphatidylinositol metabolic process

Gene Ontology
Source: GO:0046488
Synonyms:
  • PtdIns metabolic process
  • PtdIns metabolism
Branch: biological process
Genes: Fig4 (Mmu)...Fig4 (Rno)...FIG4 (Hsa)

Tg(GFAP-Fig4)#Mm

(Mus musculus)
Allele/Variant
Source: MGI:5431007
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Tg(GFAP-Fig4)#Mm
Construct Expressed Component: Fig4 (Mmu)

pigmentation

Gene Ontology
Source: GO:0043473
Synonyms: Not Available
Branch: biological process
Genes: Fig4 (Mmu)...Fig4 (Rno)...FIG4 (Hsa)

Tg(Eno2-Fig4)#Mm

(Mus musculus)
Allele/Variant
Source: MGI:5431006
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Tg(Eno2-Fig4)#Mm
Construct Expressed Component: Fig4 (Mmu)

Tg(ACTB-Fig4*I41T)705Mm

(Mus musculus)
Allele/Variant
Source: MGI:5014487
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Tg(ACTB-Fig4*I41T)705Mm
Construct Expressed Component: Fig4 (Mmu)

Tg(ACTB-Fig4*I41T)721Mm

(Mus musculus)
Allele/Variant
Source: MGI:5014489
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Tg(ACTB-Fig4*I41T)721Mm
Construct Expressed Component: Fig4 (Mmu)

neuron development

Gene Ontology
Source: GO:0048666
Synonyms: Not Available
Branch: biological process
Genes: Fig4 (Rno)...Fig4 (Mmu)...FIG4 (Hsa)

myelination

Gene Ontology
Source: GO:0042552
Synonyms:
  • myelinogenesis
Branch: biological process
Genes: Fig4 (Rno)...Fig4 (Mmu)...FIG4 (Hsa)

lysosomal transport

Gene Ontology
Source: GO:0007041
Synonyms: Not Available
Branch: biological process
Genes: fig4a (Dre)

phosphatidylinositol biosynthetic process

Gene Ontology
Source: GO:0006661
Synonyms:
  • PtdIns biosynthesis
  • PtdIns biosynthetic process
Branch: biological process
Genes: FIG4 (Hsa)

Scer\GAL4FIG4-CR70613-KO-kG4

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0391332
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Scer\GAL4<FIG4-CR70613-KO-kG4>

locomotory behavior

Gene Ontology
Source: GO:0007626
Synonyms:
  • behavior via locomotion
  • locomotion in response to stimulus
Branch: biological process
Genes: FIG4 (Hsa)...Fig4 (Rno)...Fig4 (Mmu)

positive regulation of neuron projection development

Gene Ontology
Source: GO:0010976
Synonyms:
  • positive regulation of neurite biosynthesis
  • positive regulation of neurite development
Branch: biological process
Genes: FIG4 (Hsa)...Fig4 (Rno)...Fig4 (Mmu)

nuclear periphery

Gene Ontology
Source: GO:0034399
Synonyms: Not Available
Branch: cellular component
Genes: FIG4 (Sce)

lipid droplet

Gene Ontology
Source: GO:0005811
Synonyms:
  • adiposome
  • lipid body
Branch: cellular component
Genes: FIG4 (Hsa)...Fig4 (Rno)...Fig4 (Mmu)

neurodegenerative disease

Disease
Source: DOID:1289
Definition: A central nervous system disease that results in the progressive deterioration of function or structure of neurons.
Genes: fig4a (Dre)...FIG4 (Sce)...Fig4 (Rno)...Fig4 (Mmu)...FIG4 (Dme)
Alleles: FIG4 (Dme)...FIG4 (Dme)

phosphatase activity

Gene Ontology
Source: GO:0016791
Synonyms:
  • phosphatase
  • phosphoric monoester hydrolase activity
Branch: molecular function
Genes: fig4a (Dre)...fig4b (Dre)

recycling endosome

Gene Ontology
Source: GO:0055037
Synonyms:
  • ERC
  • endosomal recycling compartment
Branch: cellular component
Genes: FIG4 (Hsa)...Fig4 (Rno)...Fig4 (Mmu)

protein serine/threonine phosphatase activity

Gene Ontology
Source: GO:0004722
Synonyms:
  • magnesium-dependent protein serine/threonine phosphatase activity
  • phosphatase I
Branch: molecular function
Genes: FIG4 (Hsa)...Fig4 (Mmu)

endosome membrane

Gene Ontology
Source: GO:0010008
Synonyms:
  • endosomal membrane
Branch: cellular component
Genes: Fig4 (Rno)...Fig4 (Mmu)...FIG4 (Dme)...FIG4 (Hsa)

fungal-type vacuole membrane

Gene Ontology
Source: GO:0000329
Synonyms:
  • fungal-type vacuolar membrane
  • membrane of vacuole with cell cycle-correlated morphology
Branch: cellular component
Genes: FIG4 (Sce)

vacuolar membrane

Gene Ontology
Source: GO:0005774
Synonyms: Not Available
Branch: cellular component
Genes: FIG4 (Sce)

vacuole

Gene Ontology
Source: GO:0005773
Synonyms:
  • vacuolar carboxypeptidase Y
Branch: cellular component
Genes: FIG4 (Sce)

intracellular membrane-bounded organelle

Gene Ontology
Source: GO:0043231
Synonyms:
  • intracellular membrane-enclosed organelle
Branch: cellular component
Genes: Fig4 (Rno)...FIG4 (Dme)...Fig4 (Mmu)...FIG4 (Sce)...FIG4 (Hsa)

endomembrane system

Gene Ontology
Source: GO:0012505
Synonyms: Not Available
Branch: cellular component
Genes: fig4a (Dre)...fig4b (Dre)...FIG4 (Hsa)

(GRCh38)6:109691477G>A

(Homo sapiens)
Allele/Variant
Source: rs552856153
Genes: FIG4 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 5_prime_UTR_variant, non_coding_transcript_exon_variant, synonymous_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)6:109691477G>A
Gene Synonyms: FIG4 homolog, SAC1 domain containing lipid phosphatase...FIG4 homolog, SAC domain containing lipid phosphatase...serine-protein phosphatase FIG4...FIG4 homolog, SAC1 lipid phosphatase domain containing

(GRCh38)6:109691511C>T

(Homo sapiens)
Allele/Variant
Source: rs200063827
Genes: FIG4 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)6:109691511C>T
Gene Synonyms: FIG4 homolog, SAC1 domain containing lipid phosphatase...FIG4 homolog, SAC domain containing lipid phosphatase...serine-protein phosphatase FIG4...FIG4 homolog, SAC1 lipid phosphatase domain containing

(GRCh38)6:109715125C>T

(Homo sapiens)
Allele/Variant
Source: rs765676819
Genes: FIG4 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 5_prime_UTR_variant, non_coding_transcript_exon_variant, synonymous_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)6:109715125C>T
Gene Synonyms: FIG4 homolog, SAC1 domain containing lipid phosphatase...FIG4 homolog, SAC domain containing lipid phosphatase...serine-protein phosphatase FIG4...FIG4 homolog, SAC1 lipid phosphatase domain containing