[object Object]

Category

123 results for Pyy

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PYY

(Homo sapiens)

Gene

Name: peptide YY

Synonyms: PYY1, prepro-PYY, peptide tyrosine tyrosine, PYY-I

Source: HGNC:9748

Biotype: protein coding gene

Symbol: PYY (Hsa)

Symbol: PYY

Strict Orthology Symbols: Pyy

Allele/Variant (27)

Pyy

(Mus musculus)

Gene

Name: peptide YY

Synonyms: Yy, GHYY, MGC:19143, peptide-YY, RATGHYY

Source: MGI:99924

Biotype: protein coding gene

Symbol: Pyy (Mmu)

Symbol: Pyy

Automated Gene Synopsis: Orthologous to several human genes including PYY (peptide YY).

Strict Orthology Symbols: Pyy

Alleles: Pyy (Mmu)...Pyy (Mmu)...Pyy (Mmu)...Pyy (Mmu)...Pyy (Mmu)

Pyy

(Rattus norvegicus)

Gene

Name: peptide YY

Synonyms: Yy, GHYY, peptide YY (mapped), Pyy_mapped, peptide-YY, peptide tyrosine tyrosine, RATGHYY, Peptide tyrosine-tyrosine (YY)

Source: RGD:1593289

Biotype: protein coding gene

Symbol: Pyy (Rno)

Symbol: Pyy

Gene Synopsis: Orthologous to several human genes including PYY (peptide YY); INTERACTS WITH aldehydo-D-glucose; ammonium

Automated Gene Synopsis: Orthologous to several human genes including PYY (peptide YY).

Strict Orthology Symbols: Pyy

Allele/Variant (6)

pyyb

(Danio rerio)

Gene

Name: peptide YYb

Synonyms: si:ch211-250b22.5

Source: ZFIN:ZDB-GENE-060215-2

Biotype: protein coding gene

Symbol: pyyb (Dre)

Automated Gene Synopsis: Orthologous to human PYY (peptide YY).

Strict Orthology Symbols: Pyy

Symbol: pyyb

pyya

(Danio rerio)

Gene

Name: peptide YYa

Synonyms: pyy, PYYa, zgc:194175, zgc:194161

Source: ZFIN:ZDB-GENE-980526-71

Biotype: protein coding gene

Symbol: pyya (Dre)

Automated Gene Synopsis: Orthologous to several human genes including PYY (peptide YY).

Synonyms: pyy...pyy

Strict Orthology Symbols: Pyy

Symbol: pyya

pyy

(Xenopus tropicalis)

Gene

Name: peptide YY

Synonyms: pyy, pyy1, peptide YY

Source: Xenbase:XB-GENE-986969

Biotype: gene

Symbol: pyy (Xtr)

Symbol: pyy

Synonyms: pyy...pyy

Strict Orthology Symbols: pyy.S...pyy.L

pyy.S

(Xenopus laevis)

Gene

Name: peptide YY

Synonyms: pyy1, pyy.S, peptide YY

Source: Xenbase:XB-GENE-17343335

Biotype: gene

Symbol: pyy.S (Xla)

Automated Gene Synopsis: Orthologous to human PYY (peptide YY).

Strict Orthology Symbols: pyy...PYY

Symbol: pyy.S

pyy.L

(Xenopus laevis)

Gene

Name: peptide YY

Synonyms: pyy1, peptide YY, pyy.L

Source: Xenbase:XB-GENE-17343334

Biotype: gene

Symbol: pyy.L (Xla)

Automated Gene Synopsis: Orthologous to human PYY (peptide YY).

Strict Orthology Symbols: pyy...PYY

Symbol: pyy.L

Pyy^{tm1(KOMP)Wtsi}

(Mus musculus)

Allele/Variant

Source: MGI:4363090

Genes: Pyy (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Pyy (Mmu)

Genes: Pyy (Mmu)

Symbol: Pyy^{tm1(KOMP)Wtsi}

Gene (1)

Pyy^tm1Batt

(Mus musculus)

Allele/Variant

Source: MGI:3771166

Genes: Pyy (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Pyy (Mmu)

Genes: Pyy (Mmu)

Symbol: Pyy^tm1Batt

Pyy^em5Gpt

(Mus musculus)

Allele/Variant

Source: MGI:7305040

Genes: Pyy (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Pyy (Mmu)

Genes: Pyy (Mmu)

Symbol: Pyy^em5Gpt

Gene (1)

Pyy^em1Cya

(Mus musculus)

Allele/Variant

Source: MGI:7795699

Genes: Pyy (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Pyy (Mmu)

Genes: Pyy (Mmu)

Symbol: Pyy^em1Cya

Gene (1)

Pyy^tm1(cre)Hhzg

(Mus musculus)

Allele/Variant

Source: MGI:3664105

Genes: Pyy (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Pyy (Mmu)

Genes: Pyy (Mmu)

Symbol: Pyy^tm1(cre)Hhzg

Construct Regulatory Region: Pyy (Mmu)

Constructs: Pyy< construct

Pyy^em1Smoc

(Mus musculus)

Allele/Variant

Source: MGI:7626772

Genes: Pyy (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Pyy (Mmu)

Genes: Pyy (Mmu)

Symbol: Pyy^em1Smoc

Gene (1)

Pyy^tm1.1Batt

(Mus musculus)

Allele/Variant

Source: MGI:3771165

Genes: Pyy (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Pyy (Mmu)

Genes: Pyy (Mmu)

Symbol: Pyy^tm1.1Batt

Pyy^tm1Able

(Mus musculus)

Allele/Variant

Source: MGI:3580424

Genes: Pyy (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Pyy (Mmu)

Genes: Pyy (Mmu)

Symbol: Pyy^tm1Able

Pyy^tm1Mws

(Mus musculus)

Allele/Variant

Source: MGI:3771716

Genes: Pyy (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Pyy (Mmu)

Genes: Pyy (Mmu)

Symbol: Pyy^tm1Mws

Pyy^{tm1(EGFP/cre/ERT2)Wtsi}

(Mus musculus)

Allele/Variant

Source: MGI:5633829

Genes: Pyy (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Pyy (Mmu)

Genes: Pyy (Mmu)

Symbol: Pyy^{tm1(EGFP/cre/ERT2)Wtsi}

Construct Regulatory Region: Pyy (Mmu)

Constructs: Pyy< construct

Gene (1)

PYY2

(Homo sapiens)

Gene

Name: peptide YY 2 (pseudogene)

Synonyms: peptide YY, 2 (pseudogene)

Source: HGNC:9749

Biotype: pseudogene

Symbol: PYY2 (Hsa)

Symbol: PYY2

PYY3

(Homo sapiens)

Gene

Name: peptide YY 3 (pseudogene)

Synonyms: PYY-III, peptide YY, 3 (pseudogene)

Source: HGNC:31855

Biotype: pseudogene

Symbol: PYY3 (Hsa)

Strict Orthology Symbols: Pyy

Symbol: PYY3

Pyy^tm1Able/Pyy^tm1Able [background:] involves: 129S6/SvEvTac * C57BL/6 * FVB/N

(Mus musculus)

Model

Id: MGI:3581656

Synonyms: Not Available

Symbol: Pyy/Pyy [background:] involves: 129S6/SvEvTac * C57BL/6 * FVB/N (Mmu)

Genes: Pyy (Mmu)

Alleles: Pyy (Mmu)

Name: Pyy/Pyy [background:] involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Gene (1)

Pyy^tm1(cre)Hhzg/Pyy^tm1(cre)Hhzg [background:] involves: 129

(Mus musculus)

Model

Id: MGI:3664650

Synonyms: Not Available

Symbol: Pyy/Pyy [background:] involves: 129 (Mmu)

Genes: Pyy (Mmu)

Alleles: Pyy (Mmu)

Name: Pyy/Pyy [background:] involves: 129

Gene (1)

Pyy^tm1Batt/Pyy^tm1Batt [background:] involves: C57BL/6 * SJL

(Mus musculus)

Model

Id: MGI:3771167

Synonyms: Not Available

Symbol: Pyy/Pyy [background:] involves: C57BL/6 * SJL (Mmu)

Genes: Pyy (Mmu)

Alleles: Pyy (Mmu)

Name: Pyy/Pyy [background:] involves: C57BL/6 * SJL

Gene (1)

Pyy^tm1Mws/Pyy^tm1Mws [background:] involves: C57BL/6J

(Mus musculus)

Model

Id: MGI:3771731

Synonyms: Not Available

Symbol: Pyy/Pyy [background:] involves: C57BL/6J (Mmu)

Genes: Pyy (Mmu)

Alleles: Pyy (Mmu)

Name: Pyy/Pyy [background:] involves: C57BL/6J

Gene (1)

Pyy^tm1.1Batt/Pyy^tm1.1Batt [background:] involves: C57BL/6 * FVB/N * SJL

(Mus musculus)

Model

Id: MGI:3771168

Synonyms: Not Available

Symbol: Pyy/Pyy [background:] involves: C57BL/6 * FVB/N * SJL (Mmu)

Genes: Pyy (Mmu)

Alleles: Pyy (Mmu)

Name: Pyy/Pyy [background:] involves: C57BL/6 * FVB/N * SJL

Gene (1)

neuropeptide Y receptor binding

Gene Ontology

Source: GO:0031841

Synonyms:

NPY receptor binding
neuropeptide Y receptor ligand

Branch: molecular function

Genes: PYY3 (Hsa)...PYY (Hsa)...Pyy (Rno)...pyyb (Dre)...Pyy (Mmu)

Genes Annotated with this GO Term (15)

negative regulation of response to food

Gene Ontology

Source: GO:0032096

Synonyms:

down regulation of response to food
down-regulation of response to food

Branch: biological process

Genes: Pyy (Rno)...Pyy (Mmu)

Genes Annotated with this GO Term (56)

type 2 neuropeptide Y receptor binding

Gene Ontology

Source: GO:0031843

Synonyms:

type 2 neuropeptide Y receptor ligand

Branch: molecular function

Genes: pyyb (Dre)...pyya (Dre)

Genes Annotated with this GO Term (3)

type 4 neuropeptide Y receptor binding

Gene Ontology

Source: GO:0031844

Synonyms:

pancreatic polypeptide receptor binding
type 4 neuropeptide Y receptor ligand

Branch: molecular function

Genes: pyyb (Dre)

Genes Annotated with this GO Term (1)

feeding behavior

Gene Ontology

Source: GO:0007631

Synonyms:

behavioral response to food
behavioural response to food

Branch: biological process

Genes: PYY3 (Hsa)...pyyb (Dre)...Pyy (Mmu)...PYY (Hsa)...Pyy (Rno)

Genes Annotated with this GO Term (448)

eating behavior

Gene Ontology

Source: GO:0042755

Synonyms:

eating behaviour

Branch: biological process

Genes: Pyy (Mmu)...PYY (Hsa)...Pyy (Rno)

Genes Annotated with this GO Term (153)

neuropeptide hormone activity

Gene Ontology

Source: GO:0005184

Synonyms:

neurohormone

Branch: molecular function

Genes: PYY3 (Hsa)...pyyb (Dre)...Pyy (Mmu)...PYY (Hsa)...Pyy (Rno)

Genes Annotated with this GO Term (154)

Liraglutide + PYY3-36 combination therapy mimics effects of Roux-en-Y bypass on early NAFLD whilst lacking-behind in metabolic improvements.

(Rattus norvegicus)

HTP Dataset Index

High-Throughput (HTP) Dataset Index metadata provided by RGD

ID: GEO:GSE192425

Tags: unclassified

Summary: Background: Non-alcoholic fatty liver disease (NAFLD) is common in the general population. Treatment options for NAFLD are very limited, GLP-1 analogues, however, seem to be effective. Roux-en-Y gastric bypass (RYGB) is highly effective in terms of body weight loss and improves histologic and metabolic markers of NAFLD. We directly compared the effects of RYGB and a treatment with liraglutide and/or peptide tyrosine tyrosine 3-36 (PYY3-36) on early NAFLD. Methods: High-fat diet (HFD)-induced obese male Wistar rats were randomized into 6 treatment groups: RYGB, sham-operation (Sham), liraglutide (0.4mg/kg/day), PYY3-36 (0.1mg/kg/day), li-raglutide+PYY3-36 and saline. Following intervention and after an observation period of 4 weeks liver samples were histologically evaluated, ELISAs and RT-qPCRs +RNA sequencing were per-formed. Results: RYGB and liraglutide+PYY3-36 induced a similar body weight loss and marked histological improvements with significantly less steatosis compared to sham/saline. However, only RYGB induced significant metabolic improvements and mRNA expression changes. Con-clusions: liraglutide+PYY3-36 combination therapy mimics the positive effects of RYGB on weight reduction and on hepatic steatosis, while its effects on insulin resistance and adipose tissue dys-function (adiponectin/leptin ratio) lack behind RYGB.

Symbol: Liraglutide + PYY3-36 combination therapy mimics effects of Roux-en-Y bypass on early NAFLD whilst lacking-behind

intestinal epithelial cell differentiation

Gene Ontology

Source: GO:0060575

Synonyms: Not Available

Branch: biological process

Genes: PYY (Hsa)

Genes Annotated with this GO Term (97)

Gt(ROSA)26Sor^tm1(Pyy)Paba

(Mus musculus)

Allele/Variant

Source: MGI:5447471

Genes: Gt(ROSA)26Sor (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Gt(ROSA)26SorPyy)Paba>

Construct Expressed Component: Pyy (Mmu)

Gene (1)

T(Chr03:eve1,hoxb5a,pyy,rarab,thra)b245/+ (AB)

(Danio rerio)

Model

Id: ZFIN:ZDB-FISH-150901-14525

Synonyms: Not Available

Name: T(Chr03:eve1,hoxb5a,pyy,rarab,thra)b245/+ (AB)

Tg(Pyy-EGFP)2Rali

(Mus musculus)

Allele/Variant

Source: MGI:6479079

Genes: Not Available

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Tg(Pyy-EGFP)2Rali

T(Chr03:eve1,hoxb5a,pyy,rarab,thra)b245

(Danio rerio)

Model

Id: ZFIN:ZDB-FISH-150901-17126

Synonyms: Not Available

Name: T(Chr03:eve1,hoxb5a,pyy,rarab,thra)b245

T(Chr03:eve1,hoxb5a,pyy,rarab,thra)b245/b245 (AB)

(Danio rerio)

Model

Id: ZFIN:ZDB-FISH-150901-7977

Synonyms: Not Available

Name: T(Chr03:eve1,hoxb5a,pyy,rarab,thra)b245/b245 (AB)

T(Chr03:eve1,hoxb5a,pyy,rarab,thra)b447/b447

(Danio rerio)

Model

Id: ZFIN:ZDB-FISH-150901-29074

Synonyms: Not Available

Name: T(Chr03:eve1,hoxb5a,pyy,rarab,thra)b447/b447

hormone activity

Gene Ontology

Source: GO:0005179

Synonyms:

cAMP generating peptide activity
glycopeptide hormone

Branch: molecular function

Genes: PYY3 (Hsa)...pyyb (Dre)...Pyy (Rno)...pyya (Dre)...PYY (Hsa)

Genes Annotated with this GO Term (622)

Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor^tm1(Pyy)Paba [background:] involves: 129S4/SvJae

(Mus musculus)

Model

Id: MGI:5447473

Synonyms: Not Available

Name: Gt(ROSA)26Sor/Gt(ROSA)26SorPyy)Paba> [background:] involves: 129S4/SvJae

Gene (1)

Roux-en-Y gastric bypass and caloric restriction but not gut hormone-based treatments profoundly impact the hypothalamic transcriptome in obese rats

(Rattus norvegicus)

HTP Dataset Index

High-Throughput (HTP) Dataset Index metadata provided by RGD

ID: GEO:GSE190218

Tags: unclassified

Summary: Background: The hypothalamus is an important brain region for the regulation of energy balance. Roux-en-Y gastric bypass (RYGB) surgery and gut hormone-based treatments are known to reduce body weight, but their effects on hypothalamic gene expression and signaling pathways are poorly studied. Methods: Diet-induced obese male Wistar rats were randomized into the following groups: RYGB, sham-operation, sham + body weight-matched (BWM) to the RYGB group, osmotic minipump delivering PYY3-36 (0.1mg/kg/day), liraglutide s.c. (0.4mg/kg/day), PYY3-36+liraglutide and saline. All groups (except BWM) were kept on a free choice of high- and low-fat diets. Four weeks after interventions, hypothalami were collected for RNA-sequencing. Results: While rats in the RYGB, BWM and PYY3-36+liraglutide groups had comparable reductions in body weight, only RYGB and BWM treatment had a major impact on hypothalamic gene expression. In these groups, hypothalamic leptin receptor expression as well as the JAK–STAT, PI3K-Akt and AMPK signaling pathways were upregulated. No significant changes could be detected in PYY3-36+liraglutide, liraglutide and PYY treated groups. Conclusions: Despite causing similar body weight changes compared to RYGB and BWM, PYY3-36+liraglutide treatment does not impact hypothalamic gene expression. Whether this striking difference is favorable or unfavorable to metabolic health in the long term requires further investigation.