Version: 8.2.0Date: Wed Aug 27 2025
Category
Setdb1
(Rattus norvegicus)Gene
Name: SET domain bifurcated histone lysine methyltransferase 1
Synonyms: histone-lysine N-methyltransferase SETDB1, LOC100911180, similar to Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET), Setdb1_predicted, histone-lysine N-methyltransferase SETDB1-like, LOC689883, LOC310668, SET domain, bifurcated 1 (predicted), SET domain, bifurcated 1
Source: RGD:1308370
Biotype: protein coding gene
Symbol: Setdb1 (Rno)
Symbol: Setdb1
Gene Synopsis: Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1); PARTICIPATES
Automated Gene Synopsis: Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1).
Synonyms: histone-lysine N-methyltransferase SETDB1
Strict Orthology Symbols: Setdb1
SETDB1
(Homo sapiens)Gene
Name: SET domain bifurcated histone lysine methyltransferase 1
Synonyms: histone-lysine N-methyltransferase SETDB1, KMT1E, lysine N-methyltransferase 1E, histone H3-K9 methyltransferase 4, H3-K9-HMTase4, KIAA0067, ERG-associated protein with a SET domain, ESET, SET domain, bifurcated 1, tudor domain containing 21, SET domain bifurcated 1, H3-K9-HMTase 4, TDRD21, ERG-associated protein with SET domain, KG1T, ESET, histone-lysine N-methyltransferase, H3lysine-9 specific 4
Source: HGNC:10761
Biotype: protein coding gene
Symbol: SETDB1 (Hsa)
Symbol: SETDB1
Synonyms: histone-lysine N-methyltransferase SETDB1
Strict Orthology Symbols: Setdb1
Setdb1
(Mus musculus)Gene
Name: SET domain, bifurcated 1
Synonyms: KMT1E, mKIAA0067, expressed sequence AU022152, AU022152, ESET
Source: MGI:1934229
Biotype: protein coding gene
Symbol: Setdb1 (Mmu)
Symbol: Setdb1
Automated Gene Synopsis: Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1).
Strict Orthology Symbols: Setdb1
Alleles: Setdb1
setdb1
(Xenopus tropicalis)Gene
Name: SET domain bifurcated 1
Synonyms: setdb1, SET domain bifurcated 1
Source: Xenbase:XB-GENE-853380
Biotype: gene
Symbol: setdb1 (Xtr)
Symbol: setdb1
Automated Gene Synopsis: Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1).
Synonyms: setdb1...setdb1
Strict Orthology Symbols: Setdb1
setdb1a
(Danio rerio)Gene
Name: SET domain bifurcated histone lysine methyltransferase 1a
Synonyms: fc07d03, si:ch211-81a5.6, wu:fc07d03
Source: ZFIN:ZDB-GENE-030131-2421
Biotype: protein coding gene
Symbol: setdb1a (Dre)
Automated Gene Synopsis: Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1).
Strict Orthology Symbols: Setdb1
Symbol: setdb1a
setdb1b
(Danio rerio)Gene
Name: SET domain bifurcated histone lysine methyltransferase 1b
Synonyms: im:7143091, zgc:152899, wu:fa04a12, wu:fj80h02
Source: ZFIN:ZDB-GENE-061013-224
Biotype: protein coding gene
Symbol: setdb1b (Dre)
Automated Gene Synopsis: Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1).
Strict Orthology Symbols: Setdb1
Symbol: setdb1b
setdb1.L
(Xenopus laevis)Gene
Name: SET domain bifurcated 1
Synonyms: setdb1.L, SET domain bifurcated 1
Source: Xenbase:XB-GENE-866480
Biotype: gene
Symbol: setdb1.L (Xla)
Automated Gene Synopsis: Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1).
Strict Orthology Symbols: setdb1...SETDB1
Symbol: setdb1.L
setdb1.S
(Xenopus laevis)Gene
Name: SET domain bifurcated 1
Synonyms: SET domain bifurcated 1, setdb1.S
Source: Xenbase:XB-GENE-17337298
Biotype: gene
Symbol: setdb1.S (Xla)
Automated Gene Synopsis: Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1).
Strict Orthology Symbols: setdb1...SETDB1
Symbol: setdb1.S
Setdb1tm1Wcs
(Mus musculus)Allele/Variant
Source: MGI:5903612
Genes: Setdb1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Setdb1
Genes: Setdb1 (Mmu)
Symbol: Setdb1tm1Wcs
Setdb1em1Cya
(Mus musculus)Allele/Variant
Source: MGI:7796075
Genes: Setdb1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Setdb1
Genes: Setdb1 (Mmu)
Symbol: Setdb1em1Cya
Setdb1tm2.1Enl
(Mus musculus)Allele/Variant
Source: MGI:4462266
Genes: Setdb1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Setdb1
Genes: Setdb1 (Mmu)
Symbol: Setdb1tm2.1Enl
Setdb1tm2.2Enl
(Mus musculus)Allele/Variant
Source: MGI:4462267
Genes: Setdb1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Setdb1
Genes: Setdb1 (Mmu)
Symbol: Setdb1tm2.2Enl
Setdb1Gt(RRK370)Byg
(Mus musculus)Allele/Variant
Source: MGI:4130214
Genes: Setdb1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Setdb1
Genes: Setdb1 (Mmu)
Symbol: Setdb1Gt(RRK370)Byg
Setdb1MommeD17
(Mus musculus)Allele/Variant
Source: MGI:5515364
Genes: Setdb1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Setdb1
Genes: Setdb1 (Mmu)
Symbol: Setdb1MommeD17
Setdb1MommeD13
(Mus musculus)Allele/Variant
Source: MGI:5515361
Genes: Setdb1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Setdb1
Genes: Setdb1 (Mmu)
Symbol: Setdb1MommeD13
Setdb1em6Gpt
(Mus musculus)Allele/Variant
Source: MGI:7305986
Genes: Setdb1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Setdb1
Genes: Setdb1 (Mmu)
Symbol: Setdb1em6Gpt
Setdb1tm1c(EUCOMM)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:6188271
Genes: Setdb1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Setdb1
Genes: Setdb1 (Mmu)
Symbol: Setdb1tm1c(EUCOMM)Wtsi
Setdb1tm1Smoc
(Mus musculus)Allele/Variant
Source: MGI:7292266
Genes: Setdb1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Setdb1
Genes: Setdb1 (Mmu)
Symbol: Setdb1tm1Smoc
Setdb1tm1.2Yshk
(Mus musculus)Allele/Variant
Source: MGI:7571449
Genes: Setdb1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Setdb1
Genes: Setdb1 (Mmu)
Symbol: Setdb1tm1.2Yshk
Setdb1tm1.1Yshk
(Mus musculus)Allele/Variant
Source: MGI:5440719
Genes: Setdb1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Setdb1
Genes: Setdb1 (Mmu)
Symbol: Setdb1tm1.1Yshk
Setdb1tm1Enl
(Mus musculus)Allele/Variant
Source: MGI:3040431
Genes: Setdb1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Setdb1
Genes: Setdb1 (Mmu)
Symbol: Setdb1tm1Enl
Setdb1tm1a(EUCOMM)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:4432424
Genes: Setdb1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Setdb1
Genes: Setdb1 (Mmu)
Symbol: Setdb1tm1a(EUCOMM)Wtsi
Setdb1em1Gpt
(Mus musculus)Allele/Variant
Source: MGI:7305985
Genes: Setdb1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Setdb1
Genes: Setdb1 (Mmu)
Symbol: Setdb1em1Gpt
Setdb1em2Cya
(Mus musculus)Allele/Variant
Source: MGI:7796076
Genes: Setdb1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Setdb1
Genes: Setdb1 (Mmu)
Symbol: Setdb1em2Cya
Setdb1-ps1
(Rattus norvegicus)Gene
Name: SET domain bifurcated histone lysine methyltransferase 1, pseudogene 1
Synonyms: mCG16729-like, similar to Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET), histone-lysine N-methyltransferase SETDB1-like, LOC689873, LOC100363520, uncharacterized protein LOC100363520
Source: RGD:2322827
Biotype: pseudogene
Symbol: Setdb1-ps1 (Rno)
Symbol: Setdb1-ps1
Id: MGI:5440723
Synonyms: Not Available
Symbol: Setdb1/Setdb1 Tg(Nes-cre)1Kag/0 [background:] Not Specified (Mmu)
Genes: Setdb1 (Mmu)
Alleles: Setdb1
Name: Setdb1/Setdb1 Tg(Nes-cre)1Kag/0 [background:] Not Specified
Model
Id: MGI:4462278
Synonyms: Not Available
Symbol: Setdb1/Setdb1 [background:] involves: 129/Sv * C57BL/6 (Mmu)
Genes: Setdb1 (Mmu)
Alleles: Setdb1
Name: Setdb1/Setdb1 [background:] involves: 129/Sv * C57BL/6
Setdb1tm1.1Yshk/Setdb1tm1.1Yshk H2az2Tg(Wnt1-cre)11Rth/H2az2+ [background:] involves: C57BL/6J * CBA/J
(Mus musculus)Model
Id: MGI:7338918
Synonyms: Not Available
Symbol: Setdb1/Setdb1 H2az2/H2az2<+> [background:] involves: C57BL/
Genes: Setdb1 (Mmu)
Alleles: Setdb1
Name: Setdb1/Setdb1 H2az2/H2az2<+> [background:] involves: C57BL/
Setdb1tm1.1Yshk/Setdb1tm1.1Yshk Emx2tm2(cre)Sia/Emx2+ [background:] involves: C57BL/6NCrlj * CBA/JNCrlj
(Mus musculus)Model
Id: MGI:5440721
Synonyms: Not Available
Symbol: Setdb1/Setdb1 Emx2/Emx2<+> [background:] involves: C57BL/6NCrlj *
Genes: Setdb1 (Mmu)
Alleles: Setdb1
Name: Setdb1/Setdb1 Emx2/Emx2<+> [background:] involves: C57BL/6NCrlj *
Model
Id: MGI:4462279
Synonyms: Not Available
Symbol: Setdb1/Setdb1 [background:] involves: 129/Sv * C57BL/6 (Mmu)
Genes: Setdb1 (Mmu)
Alleles: Setdb1
Name: Setdb1/Setdb1 [background:] involves: 129/Sv * C57BL/6
Model
Id: MGI:3041276
Synonyms: Not Available
Symbol: Setdb1/Setdb1 [background:] involves: 129S4/SvJae (Mmu)
Genes: Setdb1 (Mmu)
Alleles: Setdb1
Name: Setdb1/Setdb1 [background:] involves: 129S4/SvJae
Setdb1tm1a(EUCOMM)Wtsi/Setdb1tm1a(EUCOMM)Wtsi [background:] B6Brd;B6Dnk;B6N-Tyrc-Brd Setdb1tm1a(EUCOMM)Wtsi/Wtsi
(Mus musculus)Model
Id: MGI:6263459
Synonyms: Not Available
Symbol: Setdb1/Setdb1 [background:] B6Brd;B6Dnk;B6N-Tyr Setdb1
Genes: Setdb1 (Mmu)
Alleles: Setdb1
Name: Setdb1/Setdb1 [background:] B6Brd;B6Dnk;B6N-Tyr Setdb1
Setdb1 is required for persistence of H3K9me3 and repression of endogenous retroviruses in mouse primordial germ cells
(Mus musculus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE60377
Tags: WT vs. mutant, cell type, genotype
Summary: Transcription of endogenous retroviruses (ERVs) is inhibited by de novo DNA methylation during gametogenesis, a process initiated after birth in oocytes and at ~E15.5 in prospermatogonia. Earlier in germline development however, the genome, including most retrotransposons, is progressively demethylated, with young ERVK and ERV1 elements retaining intermediate methylation levels. As DNA methylation reaches a low point in E13.5 primordial germ cells (PGCs) of both sexes, we determined whether retrotransposons are marked by H3K9me3 and H3K27me3 using a recently developed low input ChIP-seq method. Although these repressive histone modifications are predominantly found on distinct genomic regions in E13.5 PGCs, they concurrently mark partially methylated LTRs and LINE1 elements. Germline-specific conditional knock-out (KO) of the H3K9 methyltransferase SETDB1 yields a decrease of both histone marks and DNA methylation at H3K9me3 enriched retrotransposon families. Strikingly, Setdb1-KO E13.5 PGCs show concomitant de-repression of many marked ERVs, including IAP, ETn and ERVK10C elements and ERV-proximal genes, a subset in a sex-dependent manner. Furthermore, Setdb1 deficiency is associated with a reduced number of male PGCs and postnatal hypogonadism in both sexes. Taken together, these observations reveal that SETDB1 is an essential guardian against proviral expression prior to the onset of de novo DNA methylation in the germline. H3K9me3, H3K27me3 and expression profiles in Setdb1 WT, Het and KO male and female E13.5 PGCs.
Symbol: Setdb1 is required for persistence of H3K9me3 and repression of endogenous retroviruses in mouse primordial
Name: Setdb1 is required for persistence of H3K9me3 and repression of endogenous retroviruses in mouse primordial
Model
Id: MGI:4462280
Synonyms: Not Available
Symbol: Setdb1/Setdb1 [background:] involves: 129/Sv * C57BL/6 (Mmu)
Genes: Setdb1 (Mmu)
Alleles: Setdb1
Name: Setdb1/Setdb1 [background:] involves: 129/Sv * C57BL/6
egg
(Drosophila melanogaster)Gene
Name: eggless
Synonyms: dSetdb1, Histone-lysine N-methyltransferase, Dmsetdb1, dEset, dSetDB1, EGG, SETDB1, DmSetdb1, Egg, dsetdb1, AAM70794, BcDNA:AT13877, dSETDB1, Eggless, setdb1, Setdb1, SetDB1, DmSETDB1, AAF47268 Dm, CG30426, CG12196, Dm-setdb1, CG30422
Source: FB:FBgn0086908
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1).
Synonyms: SETDB1...setdb1...Setdb1...SetDB1...SETDB1...setdb1...Setdb1...SetDB1...Setdb1
Strict Orthology Symbols: Setdb1
met-2
(Caenorhabditis elegans)Gene
Name: histone METhyltransferase-like 2
Synonyms: CELE_R05D3.11, R05D3.11
Source: WB:WBGene00019883
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to several human genes including SETDB1 (SET domain bifurcated histone lysine methyltransferase
Strict Orthology Symbols: Setdb1
Gene Ontology
Source: GO:0070828
Synonyms:
- heterochromatin organisation
Branch: biological process
Genes: SETDB1 (Hsa)...Setdb1 (Rno)...setdb1b (Dre)...Setdb1 (Mmu)...setdb1a (Dre)
Gene Ontology
Source: GO:0046974
Synonyms:
- histone H3K9 methylase activity
- histone lysine N-methyltransferase activity (H3-K9 specific)
Branch: molecular function
Genes: SETDB1 (Hsa)...Setdb1 (Rno)...setdb1b (Dre)...Setdb1 (Mmu)...setdb1a (Dre)
Gene Ontology
Source: GO:0140949
Synonyms:
- histone H3-K9 trimethylation
- histone H3K9 mono/di/trimethylase activity
Branch: molecular function
Genes: Setdb1 (Rno)...Setdb1 (Mmu)...SETDB1 (Hsa)
Source: GO:0006346
Synonyms:
- DNA methylation-dependent heterochromatin assembly
- DNA methylation-dependent heterochromatin formation
Branch: biological process
Genes: SETDB1 (Hsa)...Setdb1 (Rno)...setdb1b (Dre)...Setdb1 (Mmu)...setdb1a (Dre)
Gene Ontology
Source: GO:0140948
Synonyms:
- histone H3-K9 methylation
- histone H3K9 methylation
Branch: molecular function
Genes: Setdb1 (Mmu)...SETDB1 (Hsa)
Gene Ontology
Source: GO:0140947
Synonyms:
- histone H3-K9 trimethylation
- histone H3K9 trimethylation
Branch: molecular function
Genes: Setdb1 (Mmu)...SETDB1 (Hsa)
The methyltransferase Setdb1 is essential for meiosis and mitosis in mouse oocytes and early embryo
(Mus musculus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:E-GEOD-82002, GEO:GSE82002
Tags: WT vs. mutant, genotype
Summary: Oocytes develop the competence for meiosis and early embryogenesis during their growth. Setdb1 is a histone H3 lysine 9 (H3K9) methyltransferase required for post-implantation development and has been implicated in the transcriptional silencing of genes and endogenous retroviral elements (ERVs). To address its role in oogenesis and pre-implantation development, we conditionally deleted Setdb1 in growing oocytes. Loss of Setdb1 expression greatly impaired meiosis. It delayed meiotic resumption, altered the dynamics of chromatin condensation, and impaired kinetochore-spindle interactions, bipolar spindle organization, and chromosome segregation in more mature oocytes. The observed phenotypes related to changes in abundance of specific transcripts in mutant oocytes. Setdb1 maternally deficient embryos arrested during pre-implantation development and showed comparable defects during cell cycle progression and in chromosome segregation. Finally, transcriptional profiling data indicate that Setdb1 down-regulates rather than silences expression of ERVK and ERVL-MaLR retrotransposons and associated chimeric transcripts during oogenesis. Our results identify Setdb1 as a novel meiotic and embryonic competence factor in meiosis and mitosis, safeguarding genome integrity at the onset of life. We performed expression profiling on pools of 16 denuded GV-oocytes isolated per mouse. We used oocytes from 4 Setdb1 f/+; Zp3-cre mice and 2 Setdb1 f/- mice as controls and oocytes from 4 Setdb1 f/-; Zp3-cre mice as mutant.
Symbol: The methyltransferase Setdb1 is essential for meiosis and mitosis in mouse oocytes and early embryo
Name: The methyltransferase Setdb1 is essential for meiosis and mitosis in mouse oocytes and early embryo
Gene Ontology
Source: GO:0001833
Synonyms: Not Available
Branch: biological process
Genes: SETDB1 (Hsa)...Setdb1 (Rno)...Setdb1 (Mmu)
Gene Ontology
Source: GO:0045869
Synonyms:
- down regulation of retroviral genome replication
- down-regulation of retroviral genome replication
Branch: biological process
Genes: Setdb1 (Mmu)...SETDB1 (Hsa)...Setdb1 (Rno)
Gene Ontology
Source: GO:0033273
Synonyms: Not Available
Branch: biological process
Genes: Setdb1 (Rno)...SETDB1 (Hsa)
Source: GO:0141005
Synonyms:
- retrotransposon silencing by heterochromatin formation
Branch: biological process
Genes: SETDB1 (Hsa)...Setdb1 (Rno)...Setdb1 (Mmu)
la013550Tg
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-120806-8383
Genes: setdb1a (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: setdb1a (Dre)
Gene Ontology
Source: GO:0042054
Synonyms:
- histone N-methyltransferase activity
- histone methylase activity
Branch: molecular function
Genes: SETDB1 (Hsa)...Setdb1 (Rno)...setdb1b (Dre)...Setdb1 (Mmu)...setdb1a (Dre)
Gene Ontology
Source: GO:0140942
Synonyms:
- histone H3-K9 dimethylation
- histone H3K9 dimethylase activity
Branch: molecular function
Genes: Setdb1 (Mmu)