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249 results for apex1

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Apex1

(Rattus norvegicus)

Gene

Name: apurinic/apyrimidinic endodeoxyribonuclease 1

Synonyms: DNA repair nuclease/redox regulator APEX1, redox factor-1, APEX nuclease 1, AP endonuclease 1, DNA-(apurinic or apyrimidinic site) lyase, APEN, DNA-(apurinic or apyrimidinic site) endonuclease, apurinic-apyrimidinic endonuclease 1, apurinic/apyrimidinic endonuclease, REF-1, APEX nuclease (multifunctional DNA repair enzyme) 1, APE, Apurinic/apyrimidinic endonuclease 1, Apex

Source: RGD:2126

Biotype: protein coding gene

Symbol: Apex1 (Rno)

Symbol: Apex1

Gene Synopsis: Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1); PARTICIPATES IN base excision

Automated Gene Synopsis: Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1).

Synonyms: DNA repair nuclease/redox regulator APEX1

Strict Orthology Symbols: apex1

Apex1

(Mus musculus)

Gene

Name: apurinic/apyrimidinic endonuclease 1

Synonyms: REF-1, Ref-1, APE, HAP1, Apex

Source: MGI:88042

Biotype: protein coding gene

Symbol: Apex1 (Mmu)

Symbol: Apex1

Automated Gene Synopsis: Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1).

Strict Orthology Symbols: apex1

Alleles: Apex1 (Mmu)...Apex1 (Mmu)...Apex1 (Mmu)...Apex1 (Mmu)...Apex1 (Mmu)

APEX1

(Homo sapiens)

Gene

Name: apurinic/apyrimidinic endodeoxyribonuclease 1

Synonyms: DNA repair nuclease/redox regulator APEX1, redox factor-1, multifunctional DNA repair enzyme, deoxyribonuclease (apurinic or apyrimidinic), AP endonuclease 1, DNA-(apurinic or apyrimidinic site) lyase, APE1, APEN, DNA-(apurinic or apyrimidinic site) endonuclease, apurinic-apyrimidinic endonuclease 1, APX, apurinic/apyrimidinic exonuclease, AP lyase, AP endonuclease class I, APE, APEX nuclease (multifunctional DNA repair enzyme) 1, apurinic/apyrimidinic (abasic) endonuclease, REF1, HAP1, protein REF-1, APEX, redox factor 1

Source: HGNC:587

Biotype: protein coding gene

Symbol: APEX1 (Hsa)

Symbol: APEX1

Synonyms: DNA repair nuclease/redox regulator APEX1

Strict Orthology Symbols: apex1

apex1

(Danio rerio)

Gene

Name: APEX nuclease (multifunctional DNA repair enzyme) 1

Synonyms: zap1, zgc:66204, hm:zehn1532, wu:fc13d11

Source: ZFIN:ZDB-GENE-040426-2761

Biotype: protein coding gene

Symbol: apex1 (Dre)

Symbol: apex1

Automated Gene Synopsis: Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1).

Strict Orthology Symbols: apex1

apex1

(Xenopus tropicalis)

Gene

Name: APEX nuclease (multifunctional DNA repair enzyme) 1

Synonyms: apex1, APEX nuclease (multifunctional DNA repair enzyme) 1, xApe1

Source: Xenbase:XB-GENE-977072

Biotype: gene

Symbol: apex1

Symbol: apex1 (Xtr)

Automated Gene Synopsis: Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1).

Synonyms: apex1...apex1...apex1

Strict Orthology Symbols: apex1

Disease (15)

apex1.S

(Xenopus laevis)

Gene

Name: APEX nuclease (multifunctional DNA repair enzyme) 1

Synonyms: apex1.S, APEX nuclease (multifunctional DNA repair enzyme) 1, xApe1

Source: Xenbase:XB-GENE-17341786

Biotype: gene

Symbol: apex1.S (Xla)

Automated Gene Synopsis: Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1).

Strict Orthology Symbols: apex1

Symbol: apex1.S

Disease (11)

apex1.L

(Xenopus laevis)

Gene

Name: APEX nuclease (multifunctional DNA repair enzyme) 1

Synonyms: APEX nuclease (multifunctional DNA repair enzyme) 1, xApe1, apex1.L

Source: Xenbase:XB-GENE-977079

Biotype: gene

Symbol: apex1.L (Xla)

Automated Gene Synopsis: Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1).

Strict Orthology Symbols: apex1

Symbol: apex1.L

Disease (11)

Apex1^tm1Djc

(Mus musculus)

Allele/Variant

Source: MGI:1857955

Genes: Apex1 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Apex1 (Mmu)

Genes: Apex1 (Mmu)

Symbol: Apex1^tm1Djc

Apex1^tm1.1Juch

(Mus musculus)

Allele/Variant

Source: MGI:6118123

Genes: Apex1 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Apex1 (Mmu)

Genes: Apex1 (Mmu)

Symbol: Apex1^tm1.1Juch

Gene (1)

Apex1^em19Gpt

(Mus musculus)

Allele/Variant

Source: MGI:7309933

Genes: Apex1 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Apex1 (Mmu)

Genes: Apex1 (Mmu)

Symbol: Apex1^em19Gpt

Gene (1)

Apex1^tm1Ernst

(Mus musculus)

Allele/Variant

Source: MGI:6416531

Genes: Apex1 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Apex1 (Mmu)

Genes: Apex1 (Mmu)

Symbol: Apex1^tm1Ernst

Gene (1)

Apex1^em1Smoc

(Mus musculus)

Allele/Variant

Source: MGI:7626383

Genes: Apex1 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Apex1 (Mmu)

Genes: Apex1 (Mmu)

Symbol: Apex1^em1Smoc

Gene (1)

Apex1^tm1Smoc

(Mus musculus)

Allele/Variant

Source: MGI:7791448

Genes: Apex1 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Apex1 (Mmu)

Genes: Apex1 (Mmu)

Symbol: Apex1^tm1Smoc

Gene (1)

Apex1^tm1Ecf

(Mus musculus)

Allele/Variant

Source: MGI:2652193

Genes: Apex1 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Apex1 (Mmu)

Genes: Apex1 (Mmu)

Symbol: Apex1^tm1Ecf

Apex1^tm1Smoc

(Mus musculus)

Allele/Variant

Source: MGI:7791084

Genes: Apex1 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Apex1 (Mmu)

Genes: Apex1 (Mmu)

Symbol: Apex1^tm1Smoc

Gene (1)

Apex1^tm1Smoc

(Mus musculus)

Allele/Variant

Source: MGI:7791630

Genes: Apex1 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Apex1 (Mmu)

Genes: Apex1 (Mmu)

Symbol: Apex1^tm1Smoc

Gene (1)

Apex1^tm1Cur

(Mus musculus)

Allele/Variant

Source: MGI:1857956

Genes: Apex1 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Apex1 (Mmu)

Genes: Apex1 (Mmu)

Symbol: Apex1^tm1Cur

Apex1^tm1.1Pmc

(Mus musculus)

Allele/Variant

Source: MGI:6361426

Genes: Apex1 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Apex1 (Mmu)

Genes: Apex1 (Mmu)

Symbol: Apex1^tm1.1Pmc

Gene (1)

Apex1^tm1Smoc

(Mus musculus)

Allele/Variant

Source: MGI:7791266

Genes: Apex1 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Apex1 (Mmu)

Genes: Apex1 (Mmu)

Symbol: Apex1^tm1Smoc

Gene (1)

Apex1^tm2Cur

(Mus musculus)

Allele/Variant

Source: MGI:2664368

Genes: Apex1 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Apex1 (Mmu)

Genes: Apex1 (Mmu)

Symbol: Apex1^tm2Cur

Apex1^tm1Smoc

(Mus musculus)

Allele/Variant

Source: MGI:7786809

Genes: Apex1 (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Apex1 (Mmu)

Genes: Apex1 (Mmu)

Symbol: Apex1^tm1Smoc

Gene (1)

Apex1-ps1

(Rattus norvegicus)

Gene

Name: apurinic/apyrimidinic endodeoxyribonuclease 1, pseudogene 1

Synonyms: DNA-(apurinic or apyrimidinic site) lyase-like, LOC102550811

Source: RGD:7546113

Biotype: pseudogene

Symbol: Apex1-ps1 (Rno)

Symbol: Apex1-ps1

Apex1-ps2

(Rattus norvegicus)

Gene

Name: apurinic/apyrimidinic endodeoxyribonuclease 1, pseudogene 2

Synonyms: LOC688436, hypothetical protein LOC688436, DNA-(apurinic or apyrimidinic site) lyase-like, LOC100910631

Source: RGD:6497775

Biotype: pseudogene

Symbol: Apex1-ps2 (Rno)

Symbol: Apex1-ps2

Apex1^tm1Djc/Apex1⁺ [background:] involves: 129X1/SvJ * NTac:NIHS

(Mus musculus)

Model

Id: MGI:3834458

Synonyms: Not Available

Symbol: Apex1/Apex1<+> [background:] involves: 129X1/SvJ * NTac:NIHS (Mmu)

Genes: Apex1 (Mmu)

Alleles: Apex1 (Mmu)

Name: Apex1/Apex1<+> [background:] involves: 129X1/SvJ * NTac:NIHS

Gene (1)

Apex1^tm1Ecf/Apex1^tm1Ecf [background:] either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

(Mus musculus)

Model

Id: MGI:3576492

Synonyms: Not Available

Symbol: Apex1/Apex1 [background:] either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

Genes: Apex1 (Mmu)

Alleles: Apex1 (Mmu)

Name: Apex1/Apex1 [background:] either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

Gene (1)

apex1^kh2/kh2

(Danio rerio)

Model

Id: ZFIN:ZDB-FISH-240325-4

Synonyms: Not Available

Symbol: apex1 (Dre)

Genes: apex1 (Dre)

Name: apex1

Gene (1)

Apex1^tm1Djc/Apex1⁺ Tg(TacLIZa)A1Jsh/0 [background:] involves: 129X1/SvJ * C57BL/6 * NTac:NIHBS

(Mus musculus)

Model

Id: MGI:3834457

Synonyms: Not Available

Symbol: Apex1/Apex1<+> Tg(TacLIZa)A1Jsh/0 [background:] involves: 129X1/SvJ * C57BL/6 * NTac:NIHBS (

Genes: Apex1 (Mmu)

Alleles: Apex1 (Mmu)

Name: Apex1/Apex1<+> Tg(TacLIZa)A1Jsh/0 [background:] involves: 129X1/SvJ * C57BL/6 * NTac:NIHBS

Gene (1)

Apex1^tm1Ecf/Apex1⁺ [background:] either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

(Mus musculus)

Model

Id: MGI:2652224

Synonyms: Not Available

Symbol: Apex1/Apex1<+> [background:] either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6) (Mmu

Genes: Apex1 (Mmu)

Alleles: Apex1 (Mmu)

Name: Apex1/Apex1<+> [background:] either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

Gene (1)

Apex1^tm1Cur/Apex1^tm1Cur [background:] involves: 129S1/Sv * C57BL/6J

(Mus musculus)

Model

Id: MGI:4358401

Synonyms: Not Available

Symbol: Apex1/Apex1 [background:] involves: 129S1/Sv * C57BL/6J (Mmu)

Genes: Apex1 (Mmu)

Alleles: Apex1 (Mmu)

Name: Apex1/Apex1 [background:] involves: 129S1/Sv * C57BL/6J

Gene (1)

Apex1^tm1Cur/Apex1⁺ [background:] involves: 129S1/Sv

(Mus musculus)

Model

Id: MGI:4358411

Synonyms: Not Available

Symbol: Apex1/Apex1<+> [background:] involves: 129S1/Sv (Mmu)

Genes: Apex1 (Mmu)

Alleles: Apex1 (Mmu)

Name: Apex1/Apex1<+> [background:] involves: 129S1/Sv

Gene (1)

apex1^kh1/kh1

(Danio rerio)

Model

Id: ZFIN:ZDB-FISH-240327-2

Synonyms: Not Available

Symbol: apex1 (Dre)

Genes: apex1 (Dre)

Name: apex1

Gene (1)

Apex1^tm1Ecf/Apex1⁺ Xpc^tm1Ecf/Xpc^tm1Ecf [background:] involves: 129

(Mus musculus)

Model

Id: MGI:2652241

Synonyms: Not Available

Symbol: Apex1/Apex1<+> Xpc/Xpc [background:] involves: 129 (Mmu)

Genes: Apex1 (Mmu)

Alleles: Apex1 (Mmu)

Name: Apex1/Apex1<+> Xpc/Xpc [background:] involves: 129

Gene (2)

Apex1^tm1Djc/Apex1^tm1Djc [background:] involves: 129X1/SvJ * NTac:NIHS

(Mus musculus)

Model

Id: MGI:3834456

Synonyms: Not Available

Symbol: Apex1/Apex1 [background:] involves: 129X1/SvJ * NTac:NIHS (Mmu)

Genes: Apex1 (Mmu)

Alleles: Apex1 (Mmu)

Name: Apex1/Apex1 [background:] involves: 129X1/SvJ * NTac:NIHS

Gene (1)

Apex1^tm2Cur/Apex1^tm2Cur [background:] involves: 129S1/Sv

(Mus musculus)

Model

Id: MGI:2664369

Synonyms: Not Available

Symbol: Apex1/Apex1 [background:] involves: 129S1/Sv (Mmu)

Genes: Apex1 (Mmu)

Alleles: Apex1 (Mmu)

Name: Apex1/Apex1 [background:] involves: 129S1/Sv

Gene (1)

exo-3

(Caenorhabditis elegans)

Gene

Name: EXOnuclease 3

Synonyms: CELE_R09B3.1, R09B3.1

Source: WB:WBGene00001372

Biotype: protein coding gene

Automated Gene Synopsis: Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1).

Strict Orthology Symbols: apex1

Rrp1

(Drosophila melanogaster)

Gene

Name: Recombination repair protein 1

Synonyms: rrp, strand transferase, APEX1, CG3178, RRP1, 3178, RRP1_DROME, Rrp-1, Recombination Repair Protein 1

Source: FB:FBgn0004584

Biotype: protein coding gene

Automated Gene Synopsis: Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1).

Synonyms: APEX1...APEX1

Strict Orthology Symbols: apex1

class II DNA-(apurinic or apyrimidinic site) endonuclease activity

Gene Ontology

Source: GO:0052720

Synonyms:

class II AP endonuclease activity
class II DNA-(apurinic or apyrimidinic site) lyase activity

Branch: molecular function

Genes: APEX1 (Hsa)...Apex1 (Rno)...Apex1 (Mmu)...apex1 (Dre)

Genes Annotated with this GO Term (7)

telomere maintenance via base-excision repair

Gene Ontology

Source: GO:0097698

Synonyms: Not Available

Branch: biological process

Genes: APEX1 (Hsa)...Apex1 (Rno)...Apex1 (Mmu)

Genes Annotated with this GO Term (3)

phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands

Gene Ontology

Source: GO:0090580

Synonyms: Not Available

Branch: molecular function

Genes: APEX1 (Hsa)...Apex1 (Rno)...Apex1 (Mmu)

Genes Annotated with this GO Term (4)

double-stranded DNA exodeoxyribonuclease activity

Gene Ontology

Source: GO:0008309

Synonyms:

double-stranded DNA specific exodeoxyribonuclease activity

Branch: molecular function

Genes: APEX1 (Hsa)...Apex1 (Rno)...Apex1 (Mmu)

Genes Annotated with this GO Term (39)

site-specific endodeoxyribonuclease activity, specific for altered base

Gene Ontology

Source: GO:0016890

Synonyms: Not Available

Branch: molecular function

Genes: APEX1 (Hsa)...Apex1 (Rno)...Apex1 (Mmu)

Genes Annotated with this GO Term (6)

DNA-(abasic site) binding

Gene Ontology

Source: GO:0140431

Synonyms:

DNA AP site binding
DNA-(apurinic site) binding

Branch: molecular function

Genes: APEX1 (Hsa)...Apex1 (Rno)...Apex1 (Mmu)...apex1 (Dre)

Genes Annotated with this GO Term (7)

double-stranded DNA 3'-5' DNA exonuclease activity

Gene Ontology

Source: GO:0008311

Synonyms:

double-stranded DNA 3'-5' exodeoxyribonuclease activity
double-stranded DNA specific 3'-5' exodeoxyribonuclease activity

Branch: molecular function

Genes: APEX1 (Hsa)...Apex1 (Mmu)...Apex1 (Rno)...apex1 (Dre)

Genes Annotated with this GO Term (32)

spina bifida

Disease

Source: DOID:0080016

Definition: A neural tube defect that is characterized by incomplete closing of the spine and membranes around the spinal cord during early development.

Genes: Apex1 (Rno)...apex1.S (Xla)...apex1 (Xtr)...APEX1 (Hsa)...Apex1 (Mmu)

severe pre-eclampsia

Disease

Source: DOID:13129

Definition: A pre-eclampsia that has_symptom at least one of the following: SBP of 160mm HG or higher or DPB of 110mm HG or higher on 2 occasions at least 6 hours apart, proteinuria more than 5g in a 24-hour collection, pulmonary edema or cyanosis, oliguria, persistent headaches, epigastric pain and/or impaired liver function, thrombocytopenia, oligohydramnios, decreased fetal growth or placental abruption.

Genes: APEX1 (Hsa)...Apex1 (Rno)...Apex1 (Mmu)...apex1 (Xtr)...apex1 (Dre)