Version: 8.1.0Date: Fri Apr 18 2025
Category
bcas2
(Danio rerio)Gene
Name: BCAS2 pre-mRNA processing factor
Synonyms: cb302, zgc:101730
Source: ZFIN:ZDB-GENE-030408-5
Biotype: protein coding gene
Symbol: bcas2 (Dre)
Symbol: bcas2
Automated Gene Synopsis: Orthologous to human BCAS2 (BCAS2 pre-mRNA processing factor).
Strict Orthology Symbols: bcas2
Bcas2
(Rattus norvegicus)Gene
Name: BCAS2, pre-mRNA processing factor
Synonyms: breast carcinoma amplified sequence 2, pre-mRNA-splicing factor SPF27, LOC295334
Source: RGD:1306485
Biotype: protein coding gene
Symbol: Bcas2 (Rno)
Symbol: Bcas2
Gene Synopsis: Orthologous to human BCAS2 (BCAS2 pre-mRNA processing factor); PARTICIPATES IN spliceosome pathway; INTERACTS
Automated Gene Synopsis: Orthologous to human BCAS2 (BCAS2 pre-mRNA processing factor).
Strict Orthology Symbols: bcas2
Bcas2
(Mus musculus)Gene
Name: BCAS2 pre-mRNA processing factor
Synonyms: expressed sequence C76366, C80030, breast carcinoma amplified sequence 2, C76366, MGC:7712, 6430539P16Rik, expressed sequence AI132645, AI132645, expressed sequence C80030, RIKEN cDNA 6430539P16 gene
Source: MGI:1915433
Biotype: protein coding gene
Symbol: Bcas2 (Mmu)
Symbol: Bcas2
Automated Gene Synopsis: Orthologous to human BCAS2 (BCAS2 pre-mRNA processing factor).
Strict Orthology Symbols: bcas2
Alleles: Bcas2
BCAS2
(Homo sapiens)Gene
Name: BCAS2 pre-mRNA processing factor
Synonyms: breast carcinoma amplified sequence 2, Snt309, DNA amplified in mammary carcinoma 1 protein, SPF27, breast carcinoma-amplified sequence 2, pre-mRNA-splicing factor SPF27, spliceosome-associated protein SPF 27, BCAS2, pre-mRNA processing factor, spliceosome associated protein, amplified in breast cancer, DAM1
Source: HGNC:975
Biotype: protein coding gene
Symbol: BCAS2 (Hsa)
Symbol: BCAS2
Strict Orthology Symbols: bcas2
BCAS2
(Drosophila melanogaster)Gene
Name: BCAS2
Synonyms: CG4980, BCAS2 ortholog, dBCAS2
Source: FB:FBgn0039558
Biotype: protein coding gene
Symbol: BCAS2
Symbol: BCAS2 (Dme)
Gene Synopsis: BCAS2 (BCAS2) encodes an essential protein that regulates wing development via Delta-Notch signaling.
Automated Gene Synopsis: Orthologous to human BCAS2 (BCAS2 pre-mRNA processing factor).
Synonyms: BCAS2 ortholog
Strict Orthology Symbols: bcas2
bcas2
(Xenopus tropicalis)Gene
Name: breast carcinoma amplified sequence 2
Synonyms: breast carcinoma amplified sequence 2, bcas2
Source: Xenbase:XB-GENE-959514
Biotype: gene
Symbol: bcas2
Symbol: bcas2 (Xtr)
Automated Gene Synopsis: Orthologous to human BCAS2 (BCAS2 pre-mRNA processing factor).
Synonyms: bcas2...bcas2...bcas2
Strict Orthology Symbols: bcas2
bcas2.L
(Xenopus laevis)Gene
Name: breast carcinoma amplified sequence 2
Synonyms: bcas2.L, breast carcinoma amplified sequence 2
Source: Xenbase:XB-GENE-6078160
Biotype: gene
Symbol: bcas2.L (Xla)
Automated Gene Synopsis: Orthologous to human BCAS2 (BCAS2 pre-mRNA processing factor).
Strict Orthology Symbols: bcas2
Symbol: bcas2.L
Bcas2tm1.2Lil
(Mus musculus)Allele/Variant
Source: MGI:5909975
Genes: Bcas2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Bcas2
Genes: Bcas2 (Mmu)
Symbol: Bcas2tm1.2Lil
BCAS2HMC06156
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0322426
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: BCAS2
Construct Knockdown Component: BCAS2 (Dme)
Symbol: BCAS2HMC06156
Bcas2tm1.1Lil
(Mus musculus)Allele/Variant
Source: MGI:5909974
Genes: Bcas2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Bcas2
Genes: Bcas2 (Mmu)
Symbol: Bcas2tm1.1Lil
BCAS2HMJ22596
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0315178
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: BCAS2
Construct Knockdown Component: BCAS2 (Dme)
Symbol: BCAS2HMJ22596
Bcas2tm1Lil
(Mus musculus)Allele/Variant
Source: MGI:5909977
Genes: Bcas2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Bcas2
Genes: Bcas2 (Mmu)
Symbol: Bcas2tm1Lil
BCAS2UAS.Tag:FLAG
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0365299
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: BCAS2
Symbol: BCAS2UAS.Tag:FLAG
Construct Expressed Component: BCAS2 (Dme)
Bcas2em1Gpt
(Mus musculus)Allele/Variant
Source: MGI:7295839
Genes: Bcas2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Bcas2
Genes: Bcas2 (Mmu)
Symbol: Bcas2em1Gpt
BCAS2GD11494
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0204494
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: BCAS2
Construct Knockdown Component: BCAS2 (Dme)
Symbol: BCAS2GD11494
BCAS2P3
(Homo sapiens)Gene
Name: BCAS2 pseudogene 3
Synonyms: BCAS2, pre-mRNA processing factor pseudogene 3, breast carcinoma amplified sequence 2 pseudogene 3
Source: HGNC:39596
Biotype: pseudogene
Symbol: BCAS2P3 (Hsa)
Symbol: BCAS2P3
BCAS2P1
(Homo sapiens)Gene
Name: BCAS2 pseudogene 1
Synonyms: BCAS2, pre-mRNA processing factor pseudogene 1, breast carcinoma amplified sequence 2 pseudogene 1
Source: HGNC:39594
Biotype: pseudogene
Symbol: BCAS2P1 (Hsa)
Symbol: BCAS2P1
BCAS2P2
(Homo sapiens)Gene
Name: BCAS2 pseudogene 2
Synonyms: BCAS2, pre-mRNA processing factor pseudogene 2, breast carcinoma amplified sequence 2 pseudogene 2
Source: HGNC:39595
Biotype: pseudogene
Symbol: BCAS2P2 (Hsa)
Symbol: BCAS2P2
Bcas2-ps1
(Rattus norvegicus)Gene
Name: BCAS2, pre-mRNA processing factor, pseudogene 1
Synonyms: similar to Breast carcinoma amplified sequence 2 homolog (DNA amplified in mammary carcinoma 1 protein), LOC691344
Source: RGD:1585073
Biotype: pseudogene
Symbol: Bcas2-ps1 (Rno)
Symbol: Bcas2-ps1
Model
Id: MGI:5910024
Synonyms: Not Available
Symbol: Bcas2/Bcas2 [background:] involves: C57BL/6 * SJL (Mmu)
Genes: Bcas2 (Mmu)
Alleles: Bcas2
Name: Bcas2/Bcas2 [background:] involves: C57BL/6 * SJL
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE228983
Tags: WT vs. mutant, genotype
Summary: Oocyte meiosis is an important factor affecting female reproduction. Breast cancer amplified sequence 2 (BCAS2) is a component of the spliceosome. Previous reports have shown that BCAS2 is critical in male germ cell meiosis, oocyte development, and early embryo genome integrity. However, the role of BCAS2 in oocyte meiosis has not been reported. We used Stra8-GFP-Cre mice to knock out BCAS2 during the pachytene phase of oocytes. The results of fertility tests showed that the cko mice were infertile. Morphological analysis showed that the number of primary follicles of 2M ovary was significantly reduced and follicle development was blocked. Further analysis showed that the number of primordial follicles decreased and follicle development slowed from 7dpp ovaries. Sequencing revealed that DNA damage in oocytes could not be repaired from 5dpp. There was an abnormality in meiosis, some oocytes could not reach the diplotene stage of meiosis, and more oocytes could not develop to the dictyate stage. AS analysis reveals that abnormal variable splicing of Dazl and Diaph2 Oogens-related genes in cKO mice, with involvement of the PRP19/CDC5l complex. BCAS2 was knocked out in ovarian oocytes, and 1dpp ovaries were taken to analyze and compare the gene expression profiles of RNA-Seq data between WT and knockout groups.
Symbol: BCAS2 regulates oocyte meiosis by participating in alternative mRNA splicing
Name: BCAS2 regulates oocyte meiosis by participating in alternative mRNA splicing
Bcas2tm1.1Lil/Bcas2tm1.1Lil Tg(Zp3-cre)3Mrt/0 [background:] involves: 129 * C57BL/6 * FVB/N * SJL
(Mus musculus)Model
Id: MGI:5910025
Synonyms: Not Available
Symbol: Bcas2/Bcas2 Tg(Zp3-cre)3Mrt/0 [background:] involves: 129 * C57BL/6 * FVB/N * SJL
Genes: Bcas2 (Mmu)
Alleles: Bcas2
Name: Bcas2/Bcas2 Tg(Zp3-cre)3Mrt/0 [background:] involves: 129 * C57BL/6 * FVB/N * SJL
Model
Id: MGI:7278719
Synonyms: Not Available
Symbol: Bcas2/Bcas2 Tg(Ddx4-cre)1Ptch/0 [background:] Not Specified (Mmu)
Genes: Bcas2 (Mmu)
Alleles: Bcas2
Name: Bcas2/Bcas2 Tg(Ddx4-cre)1Ptch/0 [background:] Not Specified
BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis and male fertility
(Mus musculus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE89801
Tags: WT vs. mutant, genotype
Summary: BCAS2 (Breast cancer amplified sequence 2) is involved in multiple biological processes, including pre-mRNA splicing. However, the physiological roles of BCAS2 are still largely unclear. Here we report that BCAS2 is specifically enriched in spermatogonia of mouse testes. Conditional disruption of Bcas2 in male germ cells impairs spermatogenesis and leads to male mouse infertility. Although the spermatogonia appear grossly normal, spermatocytes in meiosis prophase I and meiosis events (recombination and synapsis) are rarely observed in the BCAS2-depleted testis. In BCAS2 null testis, 245 genes are altered in alternative splicing forms; at least three spermatogenesis-related genes (Dazl, Ehmt2 and Hmga1) can be verified. In addition, disruption of Bcas2 results in a significant decrease of the full-length form and an increase of the short form (lacking exon 8) of DAZL protein. Altogether, our results suggest that BCAS2 regulates alternative splicing in spermatogonia and the transition to meiosis initiation, and male fertility. Transcriptional profiles of P9 testes from Control and Bcas2F/-;V-cre males
Symbol: BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis and male
Name: BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis and male
bcas2hzu11/hzu11 (AB)
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-220310-27
Synonyms: Not Available
Symbol: bcas2
Genes: bcas2 (Dre)
Name: bcas2 (AB)
Bcas2tm1Lil/Bcas2tm1Lil [background:] Not Specified
(Mus musculus)Model
Id: MGI:5910023
Synonyms: Not Available
Symbol: Bcas2/Bcas2 [background:] Not Specified (Mmu)
Genes: Bcas2 (Mmu)
Alleles: Bcas2
Name: Bcas2/Bcas2 [background:] Not Specified
bcas-2
(Caenorhabditis elegans)Gene
Name: BCAS splicing factor homolog 2
Synonyms: CELE_T12A2.7, T12A2.7
Source: WB:WBGene00020441
Biotype: protein coding gene
Gene Synopsis: Is an ortholog of human BCAS2 (BCAS2 pre-mRNA processing factor).
Automated Gene Synopsis: Orthologous to human BCAS2 (BCAS2 pre-mRNA processing factor).
Strict Orthology Symbols: bcas2
tp53zdf1/zdf1; bcas2hzu11/hzu11 (AB)
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-220311-2
Synonyms: Not Available
Genes: bcas2 (Dre)
Name: tp53; bcas2 (AB)
Symbol: tp53; bcas2
Gene Ontology
Source: GO:0005662
Synonyms:
- RPA
- replication protein A
Branch: cellular component
Genes: BCAS2 (Hsa)...Bcas2 (Rno)...Bcas2 (Mmu)
Gene Ontology
Source: GO:0000974
Synonyms:
- MOS4-Associated Complex
- NTC
Branch: cellular component
Genes: BCAS2 (Hsa)...BCAS2 (Dme)...Bcas2 (Rno)...Bcas2 (Mmu)...bcas2 (Dre)
Gene Ontology
Source: GO:0071007
Synonyms:
- GT-AG catalytic step 2 spliceosome
- major catalytic step 2 spliceosome
Branch: cellular component
Genes: BCAS2 (Hsa)...Bcas2 (Mmu)...bcas2 (Dre)...Bcas2 (Rno)
Gene Ontology
Source: GO:0048599
Synonyms: Not Available
Branch: biological process
Genes: BCAS2 (Hsa)...Bcas2 (Rno)...Bcas2 (Mmu)
Gene Ontology
Source: GO:0000380
Synonyms:
- alternative nuclear mRNA splicing, via spliceosome
- splice site selection
Branch: biological process
Genes: BCAS2 (Hsa)...Bcas2 (Mmu)...Bcas2 (Rno)
Gene Ontology
Source: GO:0051225
Synonyms:
- bipolar spindle biosynthesis
- bipolar spindle formation
Branch: biological process
Genes: BCAS2 (Hsa)...Bcas2 (Mmu)...Bcas2 (Rno)
Gene Ontology
Source: GO:0001541
Synonyms:
- follicular phase
Branch: biological process
Genes: BCAS2 (Hsa)...Bcas2 (Mmu)...Bcas2 (Rno)
Gene Ontology
Source: GO:0000375
Synonyms:
- RNA splicing factor activity, transesterification mechanism
- pre-mRNA splicing factor activity
Branch: biological process
Genes: BCAS2 (Hsa)
Hsap\BCAS2C.UAS
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0283025
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hsap\BCAS2
Construct Expressed Component: BCAS2 (Hsa)
Hsap\BCAS2UAS.wt
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0283024
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hsap\BCAS2
Construct Expressed Component: BCAS2 (Hsa)
Gene Ontology
Source: GO:0071013
Synonyms:
- mammalian spliceosomal complex C
- mammalian spliceosomal complex C1
Branch: cellular component
Genes: bcas2 (Dre)...BCAS2 (Hsa)...Bcas2 (Mmu)...BCAS2 (Dme)...Bcas2 (Rno)
Gene Ontology
Source: GO:0030163
Synonyms:
- cellular protein breakdown
- cellular protein catabolic process
Branch: biological process
Genes: BCAS2 (Hsa)...Bcas2 (Mmu)...Bcas2 (Rno)
Gene Ontology
Source: GO:0048477
Synonyms:
- ovum development
Branch: biological process
Genes: BCAS2 (Hsa)...Bcas2 (Mmu)...Bcas2 (Rno)
Gene Ontology
Source: GO:0005681
Synonyms:
- spliceosome
- spliceosome complex
Branch: cellular component
Genes: bcas2 (Dre)...BCAS2 (Hsa)...Bcas2 (Mmu)...Bcas2 (Rno)
Gene Ontology
Source: GO:0000398
Synonyms:
- mRNA splicing
- nuclear mRNA splicing via U12-type spliceosome
Branch: biological process
Genes: bcas2 (Dre)...BCAS2 (Hsa)...Bcas2 (Mmu)...BCAS2 (Dme)...Bcas2 (Rno)
Gene Ontology
Source: GO:0071011
Synonyms:
- mammalian spliceosomal complex B
- mammalian spliceosomal complex B1
Branch: cellular component
Genes: BCAS2 (Dme)
Disease
Source: DOID:1612
Definition: An organ system cancer that originates in the mammary gland.
Genes: bcas2 (Xtr)...bcas2 (Dre)...BCAS2 (Hsa)...Bcas2 (Mmu)...BCAS2 (Dme)
Gene Ontology
Source: GO:0006397
Synonyms:
- mRNA maturation
Branch: biological process
Genes: bcas2 (Dre)...BCAS2 (Hsa)...BCAS2 (Dme)
Gene Ontology
Source: GO:0016607
Synonyms:
- nuclear speckle
- nuclear speckles
Branch: cellular component
Genes: BCAS2 (Hsa)...Bcas2 (Mmu)...Bcas2 (Rno)
Gene Ontology
Source: GO:0008380
Synonyms:
- pre-mRNA splicing factor activity
Branch: biological process
Genes: bcas2 (Dre)...BCAS2 (Hsa)
(R6)3R:27922285A>G
(Drosophila melanogaster)Allele/Variant
Source: NT_033777.3:g.27922285A>G
Genes: BCAS2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 5_prime_UTR_variant
Diseases: Not Available
Variant Name: (R6)3R:27922285A>G
Gene Synonyms: BCAS2 ortholog
(R6)3R:27921613C>T
(Drosophila melanogaster)Allele/Variant
Source: NT_033777.3:g.27921613C>T
Genes: BCAS2 (Dme)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: synonymous_variant
Diseases: Not Available
Variant Name: (R6)3R:27921613C>T
Gene Synonyms: BCAS2 ortholog