Version: 8.0.0
Date: Tue Jan 28 2025
746 results for card9

Card9

(Rattus norvegicus)
Gene
Name: caspase recruitment domain family, member 9
Synonyms: rCARD9, caspase recruitment domain-containing protein 9, LOC64171, caspase recruitment domain protein 9
Source: RGD:708370
Biotype: protein coding gene
Symbol: Card9 (Rno)
Symbol: Card9
Gene Synopsis: Orthologous to human CARD9 (caspase recruitment domain family member 9); PARTICIPATES IN NOD-like receptor
Automated Gene Synopsis: Orthologous to human CARD9 (caspase recruitment domain family member 9).
Strict Orthology Symbols: card9

Card9

(Mus musculus)
Gene
Name: caspase recruitment domain family, member 9
Synonyms: Gm782, LOC332579, gene model 782, (NCBI)
Source: MGI:2685628
Biotype: protein coding gene
Symbol: Card9 (Mmu)
Symbol: Card9
Automated Gene Synopsis: Orthologous to human CARD9 (caspase recruitment domain family member 9).
Strict Orthology Symbols: card9
Alleles: Card9 (Mmu)...Card9 (Mmu)...Card9 (Mmu)...Card9 (Mmu)...Card9 (Mmu)

CARD9

(Homo sapiens)
Gene
Name: caspase recruitment domain family member 9
Synonyms: caspase recruitment domain family, member 9, caspase recruitment domain-containing protein 9, caspase recruitment domain protein 9, hCARD9, IMD103, CANDF2
Source: HGNC:16391
Biotype: protein coding gene
Symbol: CARD9 (Hsa)
Symbol: CARD9
Strict Orthology Symbols: card9

card9

(Danio rerio)
Gene
Name: caspase recruitment domain family, member 9
Synonyms: si:dkey-1o2.6
Source: ZFIN:ZDB-GENE-060531-94
Biotype: protein coding gene
Symbol: card9 (Dre)
Symbol: card9
Automated Gene Synopsis: Orthologous to human CARD9 (caspase recruitment domain family member 9).
Strict Orthology Symbols: card9

card9

(Xenopus tropicalis)
Gene
Name: caspase recruitment domain family member 9
Synonyms: caspase recruitment domain family member 9, card9
Source: Xenbase:XB-GENE-986414
Biotype: gene
Symbol: card9
Symbol: card9 (Xtr)
Automated Gene Synopsis: Orthologous to human CARD9 (caspase recruitment domain family member 9).
Synonyms: card9...card9...card9
Strict Orthology Symbols: card9

card9.S

(Xenopus laevis)
Gene
Name: caspase recruitment domain family member 9
Synonyms: caspase recruitment domain family member 9, card9.S
Source: Xenbase:XB-GENE-17345776
Biotype: gene
Symbol: card9.S (Xla)
Automated Gene Synopsis: Orthologous to human CARD9 (caspase recruitment domain family member 9).
Strict Orthology Symbols: card9
Symbol: card9.S

card9.L

(Xenopus laevis)
Gene
Name: caspase recruitment domain family member 9
Synonyms: caspase recruitment domain family member 9, card9.L
Source: Xenbase:XB-GENE-6486740
Biotype: gene
Symbol: card9.L (Xla)
Automated Gene Synopsis: Orthologous to human CARD9 (caspase recruitment domain family member 9).
Strict Orthology Symbols: card9
Symbol: card9.L

Card9em1Gpt

(Mus musculus)
Allele/Variant
Source: MGI:7296244
Genes: Card9 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Card9 (Mmu)
Genes: Card9 (Mmu)
Symbol: Card9em1Gpt

Card9tm1Tks

(Mus musculus)
Allele/Variant
Source: MGI:3715521
Genes: Card9 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Card9 (Mmu)
Genes: Card9 (Mmu)
Symbol: Card9tm1Tks

Card9tm1Xlin

(Mus musculus)
Allele/Variant
Source: MGI:3698412
Genes: Card9 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Card9 (Mmu)
Genes: Card9 (Mmu)
Symbol: Card9tm1Xlin

Card9tm1a(EUCOMM)Hmgu

(Mus musculus)
Allele/Variant
Source: MGI:4841496
Genes: Card9 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Card9 (Mmu)
Genes: Card9 (Mmu)
Symbol: Card9tm1a(EUCOMM)Hmgu

Card9tm1c(EUCOMM)Hmgu

(Mus musculus)
Allele/Variant
Source: MGI:5806258
Genes: Card9 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Card9 (Mmu)
Genes: Card9 (Mmu)
Symbol: Card9tm1c(EUCOMM)Hmgu

Card9em1Yiw

(Mus musculus)
Allele/Variant
Source: MGI:7385038
Genes: Card9 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Card9 (Mmu)
Genes: Card9 (Mmu)
Symbol: Card9em1Yiw

Card9tm1Jrld

(Mus musculus)
Allele/Variant
Source: MGI:3663486
Genes: Card9 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Card9 (Mmu)
Genes: Card9 (Mmu)
Symbol: Card9tm1Jrld

Card9em1Cya

(Mus musculus)
Allele/Variant
Source: MGI:7582714
Genes: Card9 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Card9 (Mmu)
Genes: Card9 (Mmu)
Symbol: Card9em1Cya

Card9tm1Tks/Card9tm1Tks [background:] B6.129-Card9tm1Tks

(Mus musculus)
Model
Id: MGI:3716873
Synonyms: Not Available
Symbol: Card9/Card9 [background:] B6.129-Card9 (Mmu)
Genes: Card9 (Mmu)
Alleles: Card9 (Mmu)
Name: Card9/Card9 [background:] B6.129-Card9

card9xt31/xt31; s843Tg/s843Tg

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-240805-6
Synonyms: Not Available
Symbol: card9; s843Tg/s843Tg (Dre)
Genes: card9 (Dre)
Name: card9; s843Tg/s843Tg

Card9tm1Jrld/Card9tm1Jrld [background:] involves: 129P2/OlaHsd

(Mus musculus)
Model
Id: MGI:3664275
Synonyms: Not Available
Symbol: Card9/Card9 [background:] involves: 129P2/OlaHsd (Mmu)
Genes: Card9 (Mmu)
Alleles: Card9 (Mmu)
Name: Card9/Card9 [background:] involves: 129P2/OlaHsd

Card9tm1Xlin/Card9tm1Xlin [background:] involves: 129/Sv * C57BL/6

(Mus musculus)
Model
Id: MGI:3698859
Synonyms: Not Available
Symbol: Card9/Card9 [background:] involves: 129/Sv * C57BL/6 (Mmu)
Genes: Card9 (Mmu)
Alleles: Card9 (Mmu)
Name: Card9/Card9 [background:] involves: 129/Sv * C57BL/6

CARD9 attenuates Ab pathology and modifies microglial responses in an Alzheimer's disease mouse model

(Mus musculus)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE232636
Tags: WT vs. mutant, genotype
Summary: Although significant progress in recent years has been made in defining key innate immune receptors involved in Alzheimer's disease (AD), our knowledge of the specific intracellular signaling molecules that coordinate immune responses in AD remains poorly defined. In these studies, we have identified a previously undescribed role for the innate immune signaling molecule CARD9 in an amyloid beta (Ab)-mediated mouse model of AD. We specifically demonstrate that CARD9 deletion in the 5xFAD mouse model of AD leads to impaired control of Ab, worsened cognitive decline, and aberrant microglial activation. We further show that pharmacological activation of CARD9 provides a strategy to boost Ab clearance from the hippocampus. Collectively, these findings uncover a previously uncharacterized molecular signaling molecule used by the innate immune system in Ab-mediated neurological disease, and help to establish CARD9 as a novel molecular player that can be targeted in AD. Comparison of 5xFAD microglial response with or without Card9 function. 4 replicates per group of non disease (WT), Card9-deficient, 5xFAD, and 5xFAD Card9 deficient
Symbol: CARD9 attenuates Ab pathology and modifies microglial responses in an Alzheimer's disease mouse model
Name: CARD9 attenuates Ab pathology and modifies microglial responses in an Alzheimer's disease mouse model

regulation of interleukin-2 production

Gene Ontology
Source: GO:0032663
Synonyms:
  • regulation of IL-2 production
  • regulation of interleukin-2 biosynthetic process
Branch: biological process
Genes: Card9 (Mmu)...Card9 (Rno)...CARD9 (Hsa)

CBM complex

Gene Ontology
Source: GO:0032449
Synonyms:
  • CARMA1-BCL10-Malt1 complex
Branch: cellular component
Genes: card9 (Dre)...Card9 (Mmu)...Card9 (Rno)...CARD9 (Hsa)
Definition: A protein complex comprising Bcl10, MALT1 and a CARD domain-containing protein (CARD9, CARD10 or CARD11

response to aldosterone

Gene Ontology
Source: GO:1904044
Synonyms: Not Available
Branch: biological process
Genes: Card9 (Rno)...Card9 (Mmu)...CARD9 (Hsa)

response to peptidoglycan

Gene Ontology
Source: GO:0032494
Synonyms: Not Available
Branch: biological process
Genes: Card9 (Rno)...Card9 (Mmu)...CARD9 (Hsa)

host-mediated regulation of intestinal microbiota composition

Gene Ontology
Source: GO:0048874
Synonyms:
  • homeostasis of number of cells in a free-living population
  • host-induced regulation of intestinal microbiota composition
Branch: biological process
Genes: Card9 (Rno)...Card9 (Mmu)...CARD9 (Hsa)

xt31

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-240213-3
Genes: card9 (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: card9 (Dre)

response to fungus

Gene Ontology
Source: GO:0009620
Synonyms:
  • response to fungi
Branch: biological process
Genes: Card9 (Rno)...Card9 (Mmu)...CARD9 (Hsa)

positive regulation of T-helper 17 type immune response

Gene Ontology
Source: GO:2000318
Synonyms:
  • positive regulation of Th17 immune response
Branch: biological process
Genes: Card9 (Rno)...Card9 (Mmu)...CARD9 (Hsa)

positive regulation of granulocyte macrophage colony-stimulating factor production

Gene Ontology
Source: GO:0032725
Synonyms:
  • activation of granulocyte macrophage colony-stimulating factor production
  • positive regulation of GM-CSF production
Branch: biological process
Genes: Card9 (Rno)...Card9 (Mmu)...CARD9 (Hsa)

neutrophil mediated immunity

Gene Ontology
Source: GO:0002446
Synonyms: Not Available
Branch: biological process
Genes: Card9 (Rno)...Card9 (Mmu)...CARD9 (Hsa)

response to muramyl dipeptide

Gene Ontology
Source: GO:0032495
Synonyms: Not Available
Branch: biological process
Genes: Card9 (Rno)...Card9 (Mmu)...CARD9 (Hsa)

regulation of interleukin-6 production

Gene Ontology
Source: GO:0032675
Synonyms:
  • regulation of IL-6 production
  • regulation of interleukin-6 biosynthetic process
Branch: biological process
Genes: Card9 (Rno)...Card9 (Mmu)...CARD9 (Hsa)

regulation of tumor necrosis factor production

Gene Ontology
Source: GO:0032680
Synonyms:
  • regulation of TNF production
  • regulation of TNF-alpha production
Branch: biological process
Genes: Card9 (Rno)...Card9 (Mmu)...CARD9 (Hsa)

CARD domain binding

Gene Ontology
Source: GO:0050700
Synonyms: Not Available
Branch: molecular function
Genes: Card9 (Rno)...Card9 (Mmu)...CARD9 (Hsa)

antifungal innate immune response

Gene Ontology
Source: GO:0061760
Synonyms: Not Available
Branch: biological process
Genes: Card9 (Rno)...Card9 (Mmu)...CARD9 (Hsa)

positive regulation of stress-activated MAPK cascade

Gene Ontology
Source: GO:0032874
Synonyms:
  • activation of stress-activated MAPK cascade
  • positive regulation of p38 MAPK signaling
Branch: biological process
Genes: Card9 (Rno)...Card9 (Mmu)...CARD9 (Hsa)

positive regulation of interleukin-17 production

Gene Ontology
Source: GO:0032740
Synonyms:
  • activation of interleukin-17 production
  • positive regulation of CTLA-8 production
Branch: biological process
Genes: Card9 (Rno)...Card9 (Mmu)...CARD9 (Hsa)

stress-activated MAPK cascade

Gene Ontology
Source: GO:0051403
Synonyms:
  • MAPK11 cascade
  • MAPK12 cascade
Branch: biological process
Genes: Card9 (Rno)...Card9 (Mmu)...CARD9 (Hsa)

positive regulation of cytokine production involved in inflammatory response

Gene Ontology
Source: GO:1900017
Synonyms:
  • positive regulation of cytokine production involved in acute inflammatory response
  • up regulation of cytokine production involved in acute inflammatory response
Branch: biological process
Genes: Card9 (Rno)...Card9 (Mmu)...CARD9 (Hsa)

positive regulation of macrophage cytokine production

Gene Ontology
Source: GO:0060907
Synonyms: Not Available
Branch: biological process
Genes: Card9 (Rno)...Card9 (Mmu)...CARD9 (Hsa)

response to exogenous dsRNA

Gene Ontology
Source: GO:0043330
Synonyms:
  • response to exogenous double-stranded RNA
  • response to viral dsRNA
Branch: biological process
Genes: Card9 (Rno)...Card9 (Mmu)...CARD9 (Hsa)

regulation of immune response

Gene Ontology
Source: GO:0050776
Synonyms: Not Available
Branch: biological process
Genes: Card9 (Rno)...Card9 (Mmu)...CARD9 (Hsa)...card9 (Dre)

tumor necrosis factor production

Gene Ontology
Source: GO:0032640
Synonyms:
  • TNF alpha biosynthesis
  • TNF biosynthesis
Branch: biological process
Genes: Card9 (Mmu)

positive regulation of innate immune response

Gene Ontology
Source: GO:0045089
Synonyms:
  • stimulation of innate immune response
  • up regulation of innate immune response
Branch: biological process
Genes: Card9 (Rno)...Card9 (Mmu)...CARD9 (Hsa)

interleukin-6 production

Gene Ontology
Source: GO:0032635
Synonyms:
  • IL-6 production
  • interleukin-6 biosynthetic process
Branch: biological process
Genes: Card9 (Mmu)

macrophage cytokine production

Gene Ontology
Source: GO:0010934
Synonyms: Not Available
Branch: biological process
Genes: Card9 (Mmu)

positive regulation of chemokine production

Gene Ontology
Source: GO:0032722
Synonyms:
  • activation of chemokine production
  • positive regulation of chemokine biosynthetic process
Branch: biological process
Genes: Card9 (Rno)...Card9 (Mmu)...CARD9 (Hsa)

primary immunodeficiency disease

Disease
Source: DOID:612
Definition: An immune system disease that results when one or more essential parts of the immune system is missing or not working properly at birth due to a genetic mutation.
Genes: card9 (Xtr)...card9.S (Xla)...card9 (Dre)...Card9 (Mmu)...CARD9 (Hsa)

JNK cascade

Gene Ontology
Source: GO:0007254
Synonyms:
  • JNK1 cascade
  • JNK2 cascade
Branch: biological process
Genes: Card9 (Mmu)...CARD9 (Hsa)...Card9 (Rno)

positive regulation of tumor necrosis factor production

Gene Ontology
Source: GO:0032760
Synonyms:
  • activation of tumor necrosis factor production
  • positive regulation of TNF production
Branch: biological process
Genes: Card9 (Mmu)...CARD9 (Hsa)...Card9 (Rno)