Version: 8.0.0
Date: Tue Jan 28 2025
1,918 results for cenpj

CENPJ

(Homo sapiens)
Gene
Name: centromere protein J
Synonyms: BM032, CPAP, CENP-J, MGC131582, LAG-3-associated protein, MGC131581, LYST-interacting protein 1, microcephaly, primary autosomal recessive 6, LYST-interacting protein LIP1, LYST-interacting protein LIP7, MGC142222, MGC142224, SCKL4, Sas-4, Spindle assembly abnormal 4, MCPH6, SASS4, LAP, centrosomal P4.1-associated protein, LIP1
Source: HGNC:17272
Biotype: protein coding gene
Symbol: CENPJ (Hsa)
Symbol: CENPJ
Strict Orthology Symbols: cenpj

Cenpj

(Rattus norvegicus)
Gene
Name: centromere protein J
Synonyms: LOC305909
Source: RGD:1310464
Biotype: protein coding gene
Symbol: Cenpj (Rno)
Symbol: Cenpj
Gene Synopsis: Orthologous to human CENPJ (centromere protein J); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol
Automated Gene Synopsis: Orthologous to human CENPJ (centromere protein J).
Strict Orthology Symbols: cenpj

cenpj

(Xenopus tropicalis)
Gene
Name: centromere protein J
Synonyms: centromere protein J, cenpj
Source: Xenbase:XB-GENE-1013036
Biotype: gene
Symbol: cenpj (Xtr)
Symbol: cenpj
Automated Gene Synopsis: Orthologous to human CENPJ (centromere protein J).
Synonyms: cenpj...cenpj...cenpj
Strict Orthology Symbols: cenpj.L...CENPJ...Cenpj

cenpj.L

(Xenopus laevis)
Gene
Name: centromere protein J
Synonyms: cenpj.L, centromere protein J
Source: Xenbase:XB-GENE-6486084
Biotype: gene
Symbol: cenpj.L (Xla)
Automated Gene Synopsis: Orthologous to human CENPJ (centromere protein J).
Strict Orthology Symbols: cenpj
Symbol: cenpj.L

cpap

(Danio rerio)
Gene
Name: centrosome assembly and centriole elongation protein
Synonyms: CPAP, cenpj, si:dkey-46k9.9, wu:fi46g11
Source: ZFIN:ZDB-GENE-030131-6323
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to human CENPJ (centromere protein J).
Synonyms: cenpj...cenpj...cenpj
Strict Orthology Symbols: cenpj

Sas-4

(Drosophila melanogaster)
Gene
Name: Spindle assembly abnormal 4
Synonyms: DSas-4, dCPAP, Dsas4, D-sas4, CPAP, Dsas-4, DmSas4, Spindle assembly abnormal 4 ortholog, Sas4, SAS4, d-SAS-4, l(3)s2214, sas-4, dsas-4, l(3)S2214, DSAS-4, D-Sas4, CENPJ, DSas4, Drosophila Sas-4, CG10061, sas4, Spindle assembly abnormal 4 orthologue, SAS-4
Source: FB:FBgn0011020
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to human CENPJ (centromere protein J).
Synonyms: CENPJ...CENPJ
Strict Orthology Symbols: cenpj

Cpap

(Mus musculus)
Gene
Name: centrosome assembly and centriole elongation protein
Synonyms: centromere protein J, gene model 81, (NCBI), 4932437H03Rik, Sas4, Cenpj, RIKEN cDNA 4932437H03 gene, Gm81
Source: MGI:2684927
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to human CENPJ (centromere protein J).
Synonyms: Cenpj...Cenpj
Strict Orthology Symbols: cenpj

Seckel syndrome 4

Disease
Source: DOID:0070010
Definition: A Seckel syndrome that has_material_basis_in homozygous mutation in the CENPJ gene on chromosome 13q12.
Genes: cenpj (Xtr)...Cenpj (Rno)...CENPJ (Hsa)...cenpj.L (Xla)

primary autosomal recessive microcephaly 6

Disease
Source: DOID:0070290
Definition: A primary autosomal recessive microcephaly that has_material_basis_in homozygous or compound heterozygous mutation in the CENPJ gene on chromosome 13q12.
Genes: cenpj (Xtr)...CENPJ (Hsa)...Cenpj (Rno)...cenpj.L (Xla)

astral microtubule nucleation

Gene Ontology
Source: GO:0030954
Synonyms: Not Available
Branch: biological process
Genes: CENPJ (Hsa)...Cenpj (Rno)

positive regulation of establishment of protein localization

Gene Ontology
Source: GO:1904951
Synonyms:
  • activation of establishment of protein localisation
  • activation of establishment of protein localization
Branch: biological process
Genes: CENPJ (Hsa)...Cenpj (Rno)

positive regulation of centriole elongation

Gene Ontology
Source: GO:1903724
Synonyms:
  • activation of centriole elongation
  • up regulation of centriole elongation
Branch: biological process
Genes: Cenpj (Rno)...CENPJ (Hsa)

centriole elongation

Gene Ontology
Source: GO:0061511
Synonyms: Not Available
Branch: biological process
Genes: Cenpj (Rno)...CENPJ (Hsa)

procentriole replication complex

Gene Ontology
Source: GO:0120099
Synonyms: Not Available
Branch: cellular component
Genes: Cenpj (Rno)...CENPJ (Hsa)
Definition: Examples are the CPAP(CENPJ)-STIL complex, CEP192-PLK4 complex or CEP152-PLK4 complex in vertebrates.

positive regulation of centriole replication

Gene Ontology
Source: GO:0046601
Synonyms:
  • activation of centriole replication
  • stimulation of centriole replication
Branch: biological process
Genes: Cenpj (Rno)...CENPJ (Hsa)

Seckel syndrome

Disease
Source: DOID:0050569
Definition: A syndrome characterized by intrauterine growth retardation and postnatal dwarfism with microcephaly and intellectual disability.
Genes: Cenpj (Rno)...cenpj (Xtr)...CENPJ (Hsa)

RNA-seq analysis of the transcriptome changes on Cenpj depletion cortices at E15.5

(Mus musculus)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE110416
Tags: WT vs. mutant, genotype
Summary: Here, we performed RNA-seq to analyze the transcriptome changes on Cenpj depletion cortices at E15.5.RNA-Seq correlation test shows the similarity of the expression patterns between Cenpj+/+ and CenpjCKO was high.By comparing gene expression levels in Cenpj+/+ and CenpjCKO samples, GO term analysis of down-regulated genes in E15.5 CenpjCKO samples showed a significant enrichment of terms related to cell cycle, cell migration, neurogenesis, neuron differentiation and axongenesis, while the up-regulated genes were enriched in cell death, cilium assembly.KEGG signaling pathway analysis revealed that the differentially expressed genes are predicted to be involved in Wnt, MAPK, Hippo, AMPK, Notch, etc. signaling pathways. With Cenpj depletion, we identify a number of genes involved in cilium disassembly were downregulated in developing mouse cortex at E15.5 by RT-PCR, including Kif2a, Kif24, Plk1, Nek2, Ccp110 and Pla2g3, while some cilium assembly genes were upregulated, such as, Rab8a, Mks1, etc., which is in consistent with RNA-seq data, suggesting that RNA-seq data are reliable. The transcriptome changes on Cenpj depletion cortices.
Symbol: RNA-seq analysis of the transcriptome changes on Cenpj depletion cortices at E15.5
Name: RNA-seq analysis of the transcriptome changes on Cenpj depletion cortices at E15.5

centriole assembly

Gene Ontology
Source: GO:0098534
Synonyms: Not Available
Branch: biological process
Genes: CENPJ (Hsa)...Cenpj (Rno)

gamma-tubulin small complex

Gene Ontology
Source: GO:0008275
Synonyms:
  • Tub4 complex
  • gamma-tubulin small complex, centrosomal
Branch: cellular component
Genes: CENPJ (Hsa)

Loss of the centrosomal protein Cenpj leads to dysfunction of the hypothalamus and obesity in mice

(Mus musculus)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE139640
Tags: anatomical structure, baseline
Summary: Here, we identified distinct transcription factor expressed in specific cellular region. We precisely microdissected hypothalamus to isolate VZ, medial MZ and lateral MZ tissue at E12.5, which then were dissociated for RNA sequencing and three biological repeats were included. (GO) analysis of Nkx2-1-associated genes showed a significant enrichment of terms related to neuron differentiation, including neuron fate commitment, pattern specification process, stem cell development, neurotransmitter biosynthetic process, positive regulation of cell proliferation, neuropeptide hormone activity, and particularly type 4 melanocortin receptor binging. Identification of regional specific genes in mice developing hypothalamus
Symbol: Loss of the centrosomal protein Cenpj leads to dysfunction of the hypothalamus and obesity in mice
Name: Loss of the centrosomal protein Cenpj leads to dysfunction of the hypothalamus and obesity in mice

regulation of centriole replication

Gene Ontology
Source: GO:0046599
Synonyms: Not Available
Branch: biological process
Genes: CENPJ (Hsa)...Cenpj (Rno)

positive regulation of non-motile cilium assembly

Gene Ontology
Source: GO:1902857
Synonyms:
  • activation of immotile primary cilium assembly
  • activation of nonmotile primary cilia assembly
Branch: biological process
Genes: CENPJ (Hsa)...Cenpj (Rno)

primary autosomal recessive microcephaly

Disease
Source: DOID:0070296
Definition: A primary microcephaly characterized by microcephaly present at birth, where the brain is small but has normal architecture, and nonprogressive mental retardation that has_material_basis_in an autosomal recessive mutation.
Genes: cenpj (Xtr)...CENPJ (Hsa)...Cenpj (Rno)...cenpj.L (Xla)

positive regulation of spindle assembly

Gene Ontology
Source: GO:1905832
Synonyms:
  • activation of bipolar spindle biosynthesis
  • activation of bipolar spindle formation
Branch: biological process
Genes: CENPJ (Hsa)

microtubule polymerization

Gene Ontology
Source: GO:0046785
Synonyms:
  • microtubule assembly
  • microtubule formation
Branch: biological process
Genes: Cenpj (Rno)...CENPJ (Hsa)

centrosome duplication

Gene Ontology
Source: GO:0051298
Synonyms:
  • centrosome replication
Branch: biological process
Genes: Cenpj (Rno)...CENPJ (Hsa)

Hsap\CENPJUAS.cBa

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0356347
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hsap\CENPJ
Construct Expressed Component: CENPJ (Hsa)

Cpaptm1c(EUCOMM)Wtsi

(Mus musculus)
Allele/Variant
Source: MGI:5609807
Genes: Cpap (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Cenpj

centriole replication

Gene Ontology
Source: GO:0007099
Synonyms:
  • centriole duplication
  • ciliary basal body duplication
Branch: biological process
Genes: CENPJ (Hsa)...Cenpj (Rno)

Cpaptm1a(EUCOMM)Wtsi

(Mus musculus)
Allele/Variant
Source: MGI:4432238
Genes: Cpap (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Seckel syndrome
Variant Name: Not Available
Gene Synonyms: Cenpj

motile cilium assembly

Gene Ontology
Source: GO:0044458
Synonyms:
  • motile primary cilia assembly
  • motile primary cilia formation
Branch: biological process
Genes: CENPJ (Hsa)...Cenpj (Rno)

Cpaptm1d(EUCOMM)Wtsi

(Mus musculus)
Allele/Variant
Source: MGI:5613963
Genes: Cpap (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Cenpj

Cpaptm1.1Tkt

(Mus musculus)
Allele/Variant
Source: MGI:5428007
Genes: Cpap (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Cenpj

Cpaptm1b(EUCOMM)Wtsi

(Mus musculus)
Allele/Variant
Source: MGI:5609805
Genes: Cpap (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: Cenpj

positive regulation of G1/S transition of mitotic cell cycle

Gene Ontology
Source: GO:1900087
Synonyms:
  • activation of G1/S transition of mitotic cell cycle
  • up regulation of G1/S transition of mitotic cell cycle
Branch: biological process
Genes: CENPJ (Hsa)...Cenpj (Rno)

gamma-tubulin binding

Gene Ontology
Source: GO:0043015
Synonyms:
  • gamma tubulin binding
Branch: molecular function
Genes: CENPJ (Hsa)...Cenpj (Rno)

regulation of mitotic spindle organization

Gene Ontology
Source: GO:0060236
Synonyms:
  • regulation of mitotic spindle organisation
  • regulation of mitotic spindle organization and biogenesis
Branch: biological process
Genes: CENPJ (Hsa)

microcephaly

Disease
Source: DOID:10907
Definition: A congenital nervous system abnormality that is characterized by a significantly smaller than normal head in infants.
Genes: Cenpj (Rno)...cenpj (Xtr)...CENPJ (Hsa)

positive regulation of receptor signaling pathway via JAK-STAT

Gene Ontology
Source: GO:0046427
Synonyms:
  • activation of JAK-STAT cascade
  • positive regulation of STAT protein import into nucleus
Branch: biological process
Genes: Cenpj (Rno)...CENPJ (Hsa)

microtubule nucleation

Gene Ontology
Source: GO:0007020
Synonyms: Not Available
Branch: biological process
Genes: CENPJ (Hsa)

non-motile cilium assembly

Gene Ontology
Source: GO:1905515
Synonyms:
  • immotile primary cilium assembly
  • non-motile cilium formation
Branch: biological process
Genes: Cenpj (Rno)...CENPJ (Hsa)

tubulin binding

Gene Ontology
Source: GO:0015631
Synonyms: Not Available
Branch: molecular function
Genes: Cenpj (Rno)...CENPJ (Hsa)

Sas-4mNeonGreen.C

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0376243
Genes: Sas-4 (Dme)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: CENPJ

Sas-4unspecified

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0258390
Genes: Sas-4 (Dme)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: CENPJ

Sas-4CR70859-KO-kG4

(Drosophila melanogaster)
Allele/Variant
Source: FB:FBal0392708
Genes: Sas-4 (Dme)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: CENPJ

smoothened signaling pathway

Gene Ontology
Source: GO:0007224
Synonyms:
  • Shh signaling pathway
  • Sonic hedgehog signaling pathway
Branch: biological process
Genes: Cenpj (Rno)...CENPJ (Hsa)

centriole

Gene Ontology
Source: GO:0005814
Synonyms:
  • daughter centriole
  • mother centriole
Branch: cellular component
Genes: Cenpj (Rno)...CENPJ (Hsa)

ciliary basal body

Gene Ontology
Source: GO:0036064
Synonyms:
  • basal body
  • cilial basal body
Branch: cellular component
Genes: Cenpj (Rno)...CENPJ (Hsa)

protein domain specific binding

Gene Ontology
Source: GO:0019904
Synonyms:
  • protein domain-specific binding
Branch: molecular function
Genes: CENPJ (Hsa)...Cenpj (Rno)

transcription coactivator activity

Gene Ontology
Source: GO:0003713
Synonyms:
  • RNA polymerase II transcription co-activator activity
  • RNA polymerase II transcription coactivator activity
Branch: molecular function
Genes: CENPJ (Hsa)...Cenpj (Rno)