Version: 8.1.0Date: Fri Apr 18 2025
Category
djr-1.1
(Caenorhabditis elegans)Gene
Name: DJ-1 (mammalian transcriptional regulator) Related 1.1
Synonyms: B0432.2, CELE_B0432.2
Source: WB:WBGene00015184
Biotype: protein coding gene
Symbol: djr-1.1 (Cel)
Symbol: djr-1.1
Gene Synopsis: djr-1.1 encodes a glyoxylase orthologous to human DJ-1 (OMIM:602533, mutated in early-onset Parkinson...disease); DJR-1.1 is required for resistance to rotenone, a mitochondrial complex I inhibitor that mimics...D-beta-hydroxybutyrate or tauroursodeoxycholic acid, and fully rescued by both; by orthology with DJ-1, DJR...may promote stability of the transcription factors SKN-1 or SKNR-1 (homologs of mammalian NFE2L2); DJR
Cross References: WB:djr-1.1...djr-1.1...djr-1.1
PARK7
(Homo sapiens)Gene
Name: Parkinsonism associated deglycase
Synonyms: Parkinson disease (autosomal recessive, early onset) 7, protein/nucleic acid deglycase DJ-1, FLJ27376, Parkinson disease protein 7, DJ1, DJ-1, oncogene DJ1, maillard deglycase, HEL-S-67p, GATD2, FLJ34360, epididymis secretory sperm binding protein Li 67p, parkinson protein 7, FLJ92274
Source: HGNC:16369
Biotype: protein coding gene
Strict Orthology Symbols: djr-1.1
dj-1β
(Drosophila melanogaster)Gene
Name: dj-1beta
Synonyms: Dj-1beta, DJ-1B, DJ-1b, dj-1b, DJ-1, dDJ-1beta, dj1-beta, DJ-1 beta, DJ-1beta, dj-1beta, DJ1-1beta, CG1349
Source: FB:FBgn0039802
Biotype: protein coding gene
Strict Orthology Symbols: djr-1.1
DJ-1α
(Drosophila melanogaster)Gene
Name: DJ-1alpha
Synonyms: DJ-1alpha, CG6646, dj-1alpha, dDJ-1alpha, DJ-1a, DJ-1A, DJ-1, DJ-1 alpha, Dj-1alpha
Source: FB:FBgn0033885
Biotype: protein coding gene
Strict Orthology Symbols: djr-1.1
park7
(Danio rerio)Gene
Name: parkinson protein 7
Synonyms: zDJ-1, DJ-1, zgc:103725
Source: ZFIN:ZDB-GENE-041010-5
Biotype: protein coding gene
Strict Orthology Symbols: djr-1.1
Park7
(Rattus norvegicus)Gene
Name: Parkinsonism associated deglycase
Synonyms: CAP1, Parkinson disease (autosomal recessive, early onset) 7, protein/nucleic acid deglycase DJ-1, parkinson protein 7, fertility protein SP22, parkinson disease protein 7 homolog, DJ-1, Dj1, SP22, contraception-associated protein 1, maillard deglycase
Source: RGD:621808
Biotype: protein coding gene
Strict Orthology Symbols: djr-1.1
Park7
(Mus musculus)Gene
Name: Parkinson disease (autosomal recessive, early onset) 7
Synonyms: CAP1, DJ-1, Dj1, SP22
Source: MGI:2135637
Biotype: protein coding gene
Strict Orthology Symbols: djr-1.1
Gene Ontology
Source: GO:0097238
Synonyms: Not Available
Branch: biological process
Genes: djr-1.1 (Cel)
Gene Ontology
Source: GO:0061727
Synonyms: Not Available
Branch: biological process
Genes: djr-1.1 (Cel)
park7
(Xenopus tropicalis)Gene
Name: parkinson protein 7
Synonyms: park7, parkinson protein 7, sp22
Source: Xenbase:XB-GENE-1005316
Biotype: gene
Strict Orthology Symbols: djr-1.1
Gene Ontology
Source: GO:0046295
Synonyms:
- glycolate anabolism
- glycolate biosynthesis
Branch: biological process
Genes: djr-1.1 (Cel)
Gene Ontology
Source: GO:1903189
Synonyms:
- glyoxal metabolism
Branch: biological process
Genes: djr-1.1 (Cel)
Gene Ontology
Source: GO:0019172
Synonyms:
- (R)-lactate hydro-lyase
- D-lactate dehydratase
Branch: molecular function
Genes: djr-1.1 (Cel)
Gene Ontology
Source: GO:0036471
Synonyms: Not Available
Branch: biological process
Genes: djr-1.1 (Cel)
Gene Ontology
Source: GO:0009438
Synonyms:
- methylglyoxal bypass
- methylglyoxal metabolism
Branch: biological process
Genes: djr-1.1 (Cel)
Disease
Source: DOID:0060370
Definition: An early-onset Parkinson's disease that has_material_basis_in homozygous or compound heterozygous mutation in the DJ1 gene on chromosome 1p36.
Genes: djr-1.1 (Cel)
Gene Ontology
Source: GO:0019249
Synonyms:
- lactate anabolism
- lactate biosynthesis
Branch: biological process
Genes: djr-1.1 (Cel)
Source: GO:1902176
Synonyms:
- down regulation of intrinsic apoptotic signaling pathway in response to oxidative stress
- down-regulation of intrinsic apoptotic signaling pathway in response to oxidative stress
Branch: biological process
Genes: djr-1.1 (Cel)
Source: DOID:0060894
Definition: A Parkinson's disease characterized by onset of motor symptoms earlier than typically seen, usually prior to 50 years of age.
Genes: djr-1.1 (Cel)
Gene Ontology
Source: GO:0009636
Synonyms:
- detoxification response
- toxin resistance
Branch: biological process
Genes: djr-1.1 (Cel)
Disease
Source: DOID:0080855
Definition: A movement disorder that is characterized by disturbances of balance, gait and posture.
Genes: djr-1.1 (Cel)
Gene Ontology
Source: GO:0016829
Synonyms: Not Available
Branch: molecular function
Genes: djr-1.1 (Cel)
Disease
Source: DOID:8466
Definition: A retinal disease that is characterized by deterioration of the retina caused by the progressive and eventual death of the cells of the retina.
Genes: djr-1.1 (Cel)
Disease
Source: DOID:3526
Definition: A cerebrovascular disease that is characterized by an area of necrotic tissue in the brain resulting from a blockage or narrowing in the arteries supplying blood and oxygen to the brain.
Genes: djr-1.1 (Cel)
Gene Ontology
Source: GO:0006979
Synonyms: Not Available
Branch: biological process
Genes: djr-1.1 (Cel)
Source: DOID:3525
Definition: Not Available
Genes: djr-1.1 (Cel)
(WBcel235)II:291750C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003280.10:g.291750C>T
Genes: djr-1.1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 3_prime_UTR_variant
Diseases: Not Available
Variant Name: (WBcel235)II:291750C>T
Gene Cross References: djr-1.1
(WBcel235)II:291386C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003280.10:g.291386C>T
Genes: djr-1.1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)II:291386C>T
Gene Cross References: djr-1.1
(WBcel235)II:291137C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003280.10:g.291137C>T
Genes: djr-1.1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)II:291137C>T
Gene Cross References: djr-1.1
(WBcel235)II:290906A>G
(Caenorhabditis elegans)Allele/Variant
Source: NC_003280.10:g.290906A>G
Genes: djr-1.1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)II:290906A>G
Gene Cross References: djr-1.1
(WBcel235)II:291090G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003280.10:g.291090G>A
Genes: djr-1.1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)II:291090G>A
Gene Cross References: djr-1.1
Disease
Source: DOID:14330
Definition: A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions.
Genes: djr-1.1 (Cel)
(WBcel235)II:291428G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003280.10:g.291428G>A
Genes: djr-1.1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)II:291428G>A
Gene Cross References: djr-1.1
(WBcel235)II:291490G>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003280.10:g.291490G>T
Genes: djr-1.1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)II:291490G>T
Gene Cross References: djr-1.1
(WBcel235)II:291494G>C
(Caenorhabditis elegans)Allele/Variant
Source: NC_003280.10:g.291494G>C
Genes: djr-1.1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)II:291494G>C
Gene Cross References: djr-1.1
(WBcel235)II:291072G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003280.10:g.291072G>A
Genes: djr-1.1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (WBcel235)II:291072G>A
Gene Cross References: djr-1.1
(WBcel235)II:291212A>G
(Caenorhabditis elegans)Allele/Variant
Source: NC_003280.10:g.291212A>G
Genes: djr-1.1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: splice_region_variant, intron_variant
Diseases: Not Available
Variant Name: (WBcel235)II:291212A>G
Gene Cross References: djr-1.1
(WBcel235)II:291701C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003280.10:g.291701C>T
Genes: djr-1.1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)II:291701C>T
Gene Cross References: djr-1.1
(WBcel235)II:291725G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003280.10:g.291725G>A
Genes: djr-1.1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)II:291725G>A
Gene Cross References: djr-1.1
(WBcel235)II:291516G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003280.10:g.291516G>A
Genes: djr-1.1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)II:291516G>A
Gene Cross References: djr-1.1
(WBcel235)II:291027C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003280.10:g.291027C>T
Genes: djr-1.1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: stop_gained
Diseases: Not Available
Variant Name: (WBcel235)II:291027C>T
Gene Cross References: djr-1.1
(WBcel235)II:290903G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003280.10:g.290903G>A
Genes: djr-1.1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)II:290903G>A
Gene Cross References: djr-1.1
(WBcel235)II:290924C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003280.10:g.290924C>T
Genes: djr-1.1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)II:290924C>T
Gene Cross References: djr-1.1
(WBcel235)II:291104G>C
(Caenorhabditis elegans)Allele/Variant
Source: NC_003280.10:g.291104G>C
Genes: djr-1.1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)II:291104G>C
Gene Cross References: djr-1.1
(WBcel235)II:291295T>G
(Caenorhabditis elegans)Allele/Variant
Source: NC_003280.10:g.291295T>G
Genes: djr-1.1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)II:291295T>G
Gene Cross References: djr-1.1
(WBcel235)II:291400G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003280.10:g.291400G>A
Genes: djr-1.1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)II:291400G>A
Gene Cross References: djr-1.1
(WBcel235)II:290750T>G
(Caenorhabditis elegans)Allele/Variant
Source: NC_003280.10:g.290750T>G
Genes: djr-1.1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)II:290750T>G
Gene Cross References: djr-1.1
(WBcel235)II:291005T>C
(Caenorhabditis elegans)Allele/Variant
Source: NC_003280.10:g.291005T>C
Genes: djr-1.1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: synonymous_variant
Diseases: Not Available
Variant Name: (WBcel235)II:291005T>C
Gene Cross References: djr-1.1
(WBcel235)II:291370G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003280.10:g.291370G>A
Genes: djr-1.1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)II:291370G>A
Gene Cross References: djr-1.1
(WBcel235)II:291425A>G
(Caenorhabditis elegans)Allele/Variant
Source: NC_003280.10:g.291425A>G
Genes: djr-1.1 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)II:291425A>G
Gene Cross References: djr-1.1