Version: 8.0.0Date: Tue Jan 28 2025
Category
Emc3
(Rattus norvegicus)Gene
Name: ER membrane protein complex subunit 3
Synonyms: Pob, partial optokinetic response b, RGD1311566, MGC94540, transmembrane protein 111, similar to RIKEN cDNA 0610039A15, Tmem111, 30 kDa protein, LOC312640
Source: RGD:1311566
Biotype: protein coding gene
Symbol: Emc3 (Rno)
Symbol: Emc3
Gene Synopsis: Orthologous to human EMC3 (ER membrane protein complex subunit 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine
Automated Gene Synopsis: Orthologous to human EMC3 (ER membrane protein complex subunit 3).
Strict Orthology Symbols: emc3
EMC3
(Homo sapiens)Gene
Name: ER membrane protein complex subunit 3
Synonyms: TMEM111, POB, partial optokinetic response b, transmembrane protein 111, 30 kDa protein
Source: HGNC:23999
Biotype: protein coding gene
Symbol: EMC3 (Hsa)
Symbol: EMC3
Strict Orthology Symbols: emc3
Emc3
(Mus musculus)Gene
Name: ER membrane protein complex subunit 3
Synonyms: 0610039A15Rik, Pob, AI225901, RIKEN cDNA 0610039A15 gene, RGD1311566, EST AI225901, expressed sequence AW260416, Tmem111, transmembrane protein 111, AW260416
Source: MGI:1913337
Biotype: protein coding gene
Symbol: Emc3 (Mmu)
Symbol: Emc3
Automated Gene Synopsis: Orthologous to human EMC3 (ER membrane protein complex subunit 3).
Strict Orthology Symbols: emc3
Alleles: Emc3
EMC3
(Drosophila melanogaster)Gene
Name: ER membrane protein complex subunit 3
Synonyms: dPOB, dPob, subunit 3 of EMC, ER Membrane protein Complex 3, CG6750, endoplasmic reticulum membrane protein complex 3, emc3
Source: FB:FBgn0032292
Biotype: protein coding gene
Symbol: EMC3
Symbol: EMC3 (Dme)
Automated Gene Synopsis: Orthologous to human EMC3 (ER membrane protein complex subunit 3).
Synonyms: emc3...emc3...emc3
Strict Orthology Symbols: emc3
Alleles: EMC3
EMC3
(Saccharomyces cerevisiae)Gene
Name: ER Membrane protein Complex
Synonyms: YKL207W, AIM27
Source: SGD:S000001690
Biotype: protein coding gene
Symbol: EMC3 (Sce)
Symbol: EMC3
Automated Gene Synopsis: Orthologous to human EMC3 (ER membrane protein complex subunit 3).
Strict Orthology Symbols: emc3
Alleles: emc3-(aim27-L160*) (Sce)...emc3-K26L (Sce)...emc3-Δ (Sce)
emc3
(Danio rerio)Gene
Name: ER membrane protein complex subunit 3
Synonyms: loc55831, wu:fi32f05, pob, zgc:63727, wu:fj63h08
Source: ZFIN:ZDB-GENE-040426-2904
Biotype: protein coding gene
Symbol: emc3 (Dre)
Symbol: emc3
Automated Gene Synopsis: Orthologous to human EMC3 (ER membrane protein complex subunit 3).
Strict Orthology Symbols: emc3
emc3
(Xenopus tropicalis)Gene
Name: ER membrane protein complex subunit 3
Synonyms: emc3, ER membrane protein complex subunit 3
Source: Xenbase:XB-GENE-942865
Biotype: gene
Symbol: emc3
Symbol: emc3 (Xtr)
Automated Gene Synopsis: Orthologous to human EMC3 (ER membrane protein complex subunit 3).
Synonyms: emc3...emc3...emc3
Strict Orthology Symbols: emc3
EMC3-AS1
(Homo sapiens)Gene
Name: EMC3 antisense RNA 1
Synonyms: Not Available
Source: HGNC:49223
Biotype: ncRNA gene
Symbol: EMC3-AS1 (Hsa)
Symbol: EMC3-AS1
emc3.L
(Xenopus laevis)Gene
Name: ER membrane protein complex subunit 3
Synonyms: emc3.L, ER membrane protein complex subunit 3
Source: Xenbase:XB-GENE-6077877
Biotype: gene
Symbol: emc3.L (Xla)
Automated Gene Synopsis: Orthologous to human EMC3 (ER membrane protein complex subunit 3).
Strict Orthology Symbols: emc3
Symbol: emc3.L
EMC3UAS.cSa
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0304721
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: EMC3
Symbol: EMC3UAS.cSa
Construct Expressed Component: EMC3 (Dme)
emc3-Δ
(Saccharomyces cerevisiae)Allele/Variant
Source: SGD:S000281062
Genes: EMC3 (Sce)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: emc3-Δ (Sce)
Genes: EMC3 (Sce)
Symbol: emc3-Δ
Emc3tm1c(EUCOMM)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:6200599
Genes: Emc3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Emc3
Genes: Emc3 (Mmu)
Symbol: Emc3tm1c(EUCOMM)Wtsi
EMC3KK101192
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0231116
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: EMC3
Construct Knockdown Component: EMC3 (Dme)
Symbol: EMC3KK101192
Constructs: EMC3 RNAi...EMC3 RNAi
EMC3UAS.GFP
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0398004
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: EMC3
Symbol: EMC3UAS.GFP
Construct Expressed Component: EMC3 (Dme)
Emc3em1Cya
(Mus musculus)Allele/Variant
Source: MGI:7583575
Genes: Emc3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Emc3
Genes: Emc3 (Mmu)
Symbol: Emc3em1Cya
EMC3HMS02242
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0279245
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: EMC3
Construct Knockdown Component: EMC3 (Dme)
Symbol: EMC3HMS02242
EMC3U6.NIG.sgRNA
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0380771
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: EMC3
Construct Knockdown Component: EMC3 (Dme)
Symbol: EMC3U6.NIG.sgRNA
Emc3em2Cya
(Mus musculus)Allele/Variant
Source: MGI:7583576
Genes: Emc3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Emc3
Genes: Emc3 (Mmu)
Symbol: Emc3em2Cya
Emc3em1Xjz
(Mus musculus)Allele/Variant
Source: MGI:6376213
Genes: Emc3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Emc3
Genes: Emc3 (Mmu)
Symbol: Emc3em1Xjz
EMC3ninaE.PX
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0357012
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: EMC3
Symbol: EMC3ninaE.PX
Construct Expressed Component: EMC3 (Dme)
Emc3tm1b(EUCOMM)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:5629314
Genes: Emc3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Emc3
Genes: Emc3 (Mmu)
Symbol: Emc3tm1b(EUCOMM)Wtsi
EMC3GD1074
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0205197
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: intestinal cancer
Variant Name: Not Available
Symbol: EMC3
Construct Knockdown Component: EMC3 (Dme)
Symbol: EMC3GD1074
Constructs: EMC3 RNAi...EMC3 RNAi
EMC3UAS.Tag:MYC
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0398005
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: EMC3
Symbol: EMC3UAS.Tag:MYC
Construct Expressed Component: EMC3 (Dme)
Emc3tm1a(EUCOMM)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:4453751
Genes: Emc3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Emc3
Genes: Emc3 (Mmu)
Symbol: Emc3tm1a(EUCOMM)Wtsi
emc3-K26L
(Saccharomyces cerevisiae)Allele/Variant
Source: SGD:S000287362
Genes: EMC3 (Sce)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: emc3-K26L (Sce)
Genes: EMC3 (Sce)
Symbol: emc3-K26L
emc3-(aim27-L160*)
(Saccharomyces cerevisiae)Allele/Variant
Source: SGD:S000302343
Genes: EMC3 (Sce)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: emc3-(aim27-L160*) (Sce)
Genes: EMC3 (Sce)
Symbol: emc3-(aim27-L160*)
Model
Id: MGI:6461241
Synonyms: Not Available
Symbol: Emc3/Emc3<+> [background:] C57BL/6N-Emc3/Ieg (Mmu)
Genes: Emc3 (Mmu)
Alleles: Emc3
Name: Emc3/Emc3<+> [background:] C57BL/6N-Emc3/Ieg
emc3a1 (AB)
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-150901-8816
Synonyms: Not Available
Symbol: emc3
Genes: emc3 (Dre)
Name: emc3 (AB)
Emc3tm1b(EUCOMM)Wtsi/Emc3tm1b(EUCOMM)Wtsi [background:] C57BL/6N-Emc3tm1b(EUCOMM)Wtsi/Ieg
(Mus musculus)Model
Id: MGI:6262367
Synonyms: Not Available
Symbol: Emc3/Emc3 [background:] C57BL/6N-Emc3/Ieg (Mmu
Genes: Emc3 (Mmu)
Alleles: Emc3
Name: Emc3/Emc3 [background:] C57BL/6N-Emc3/Ieg
emc3a1/a1 (AB)
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-150901-701
Synonyms: Not Available
Symbol: emc3
Genes: emc3 (Dre)
Name: emc3 (AB)
emc3a1/+ (WIK/AB)
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-150901-7198
Synonyms: Not Available
Symbol: emc3
Genes: emc3 (Dre)
Name: emc3 (WIK/AB)
EMC3 conditional KO in developing lung epithelium
(Mus musculus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE90969
Tags: WT vs. mutant, genotype
Summary: EMC3 is a critical component of an endoplasmic reticulum complex that mediates the processing and trafficking of surfactant associated proteins and lipids by AT2 cells and is required for lung function and respiration at birth. Lung E18.5 Epcam sorted KO vs. Control RNASeq
Symbol: EMC3 conditional KO in developing lung epithelium
Name: EMC3 conditional KO in developing lung epithelium
Model
Id: MGI:6376225
Synonyms: Not Available
Symbol: Emc3/Emc3 Tg(CAG-cre/Esr1*)5Amc/0 [background:] involves: C57BL/6J * CBA (Mmu)
Genes: Emc3 (Mmu)
Alleles: Emc3
Name: Emc3/Emc3 Tg(CAG-cre/Esr1*)5Amc/0 [background:] involves: C57BL/6J * CBA
emc3a1/+ (AB)
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-150901-17105
Synonyms: Not Available
Symbol: emc3
Genes: emc3 (Dre)
Name: emc3 (AB)
EMC3SK2
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0382918
Genes: EMC3 (Dme)
Synonyms: Not Available
Variant Type: deletion
Molecular Consequence: frameshift_variant
Diseases: Not Available
Variant Name: Not Available
Symbol: EMC3
Gene Synonyms: emc3
Genes: EMC3 (Dme)
Symbol: EMC3SK2
EMC3SK4
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0382919
Genes: EMC3 (Dme)
Synonyms: Not Available
Variant Type: deletion
Molecular Consequence: frameshift_variant
Diseases: Not Available
Variant Name: Not Available
Symbol: EMC3
Gene Synonyms: emc3
Genes: EMC3 (Dme)
Symbol: EMC3SK4
EMC3e02662
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0161119
Genes: EMC3 (Dme)
Synonyms: Not Available
Variant Type: insertion
Molecular Consequence: 3_prime_UTR_variant
Diseases: Not Available
Variant Name: Not Available
Symbol: EMC3
Gene Synonyms: emc3
Genes: EMC3 (Dme)
Symbol: EMC3e02662
EMC3Δ4
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0304720
Genes: EMC3 (Dme)
Synonyms: Not Available
Variant Type: deletion
Molecular Consequence: transcript_ablation
Diseases: Not Available
Variant Name: Not Available
Symbol: EMC3<Δ4> (Dme)
Gene Synonyms: emc3
Genes: EMC3 (Dme)
Symbol: EMC3Δ4
EMC3G10
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0357011
Genes: EMC3 (Dme)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: 5_prime_UTR_variant
Diseases: Not Available
Variant Name: Not Available
Symbol: EMC3
Gene Synonyms: emc3
Genes: EMC3 (Dme)
Symbol: EMC3G10
EMC3G7
(Drosophila melanogaster)Allele/Variant
Source: FB:FBal0357010
Genes: EMC3 (Dme)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: Not Available
Symbol: EMC3
Gene Synonyms: emc3
Genes: EMC3 (Dme)
Symbol: EMC3G7
emc-3
(Caenorhabditis elegans)Gene
Name: EMC Endoplasmic Membrane protein Complex (yeast EMC) homolog 3
Synonyms: CELE_Y62E10A.10, Y62E10A.10
Source: WB:WBGene00013378
Biotype: protein coding gene
Gene Synopsis: Is an ortholog of human EMC3 (ER membrane protein complex subunit 3).
Automated Gene Synopsis: Orthologous to human EMC3 (ER membrane protein complex subunit 3).
Strict Orthology Symbols: emc3
tmem111.L
(Xenopus laevis)Gene
Name: transmembrane protein 111
Synonyms: transmembrane protein 111, tmem111.L
Source: Xenbase:XB-GENE-17341472
Biotype: gene
Automated Gene Synopsis: Orthologous to human EMC3 (ER membrane protein complex subunit 3).
Strict Orthology Symbols: EMC3
tmem111.S
(Xenopus laevis)Gene
Name: transmembrane protein 111
Synonyms: tmem111.S, transmembrane protein 111
Source: Xenbase:XB-GENE-5777244
Biotype: gene
Automated Gene Synopsis: Orthologous to human EMC3 (ER membrane protein complex subunit 3).
Strict Orthology Symbols: EMC3
zgc:86609
(Danio rerio)Gene
Name: zgc:86609
Synonyms: Not Available
Source: ZFIN:ZDB-GENE-050102-7
Biotype: protein coding gene
Strict Orthology Symbols: EMC3
Source: GO:0045050
Synonyms:
- protein insertion into ER membrane, stop-transfer membrane-anchor sequence mediated
- protein insertion into endoplasmic reticulum membrane by stop-transfer membrane-anchor sequence
Branch: biological process
Genes: Emc3 (Mmu)...emc3 (Dre)...EMC3 (Hsa)...Emc3 (Rno)
Gene Ontology
Source: GO:0072546
Synonyms:
- ER membrane protein complex
- endoplasmic reticulum membrane protein complex
Branch: cellular component
Genes: emc3 (Dre)...Emc3 (Rno)...Emc3 (Mmu)...EMC3 (Hsa)...EMC3 (Dme)
tmem111
(Xenopus tropicalis)Gene
Name: transmembrane protein 111
Synonyms: tmem111, transmembrane protein 111
Source: Xenbase:XB-GENE-5777177
Biotype: gene
Strict Orthology Symbols: EMC3
Gene Ontology
Source: GO:0032977
Synonyms: Not Available
Branch: molecular function
Genes: emc3 (Dre)...Emc3 (Rno)...Emc3 (Mmu)...EMC3 (Hsa)...EMC3 (Dme)
Source: GO:0071816
Synonyms:
- protein insertion of tail-anchored membrane proteins into ER membrane
- tail-anchored membrane protein insertion into endoplasmic reticulum membrane
Branch: biological process
Genes: emc3 (Dre)...Emc3 (Rno)...Emc3 (Mmu)...EMC3 (Hsa)...EMC3 (Dme)
Disease
Source: DOID:10155
Definition: A gastrointestinal system cancer that is located_in the intestine.
Genes: Emc3 (Rno)...EMC3 (Hsa)...emc3 (Dre)...Emc3 (Mmu)...EMC3 (Dme)
Alleles: EMC3