Gene

EMC3

Species
Drosophila melanogaster
Symbol
EMC3
Name
ER membrane protein complex subunit 3
Synonyms
  • CG6750
  • dPOB
Biotype
protein coding gene
Automated Description
Contributes to membrane insertase activity. Involved in rhabdomere development; rhodopsin biosynthetic process; and tail-anchored membrane protein insertion into ER membrane. Located in endoplasmic reticulum. Part of EMC complex. Is expressed in adult head; adult heart; adult midgut enterocyte; enteroblast; and enteroendocrine cell. Used to study intestinal cancer. Orthologous to human EMC3 (ER membrane protein complex subunit 3).
FB Description
ER membrane protein complex subunit 3 (EMC3) encodes a subunit of the ER membrane protein complex (EMC). In fly retinas, EMC has been shown to be essential for the biosynthesis of single-pass and multi-pass membrane proteins, but not for secretory proteins.
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13116
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensEMC39 of 9YesYes   
Mus musculusEmc39 of 9YesYes   
Rattus norvegicusEmc39 of 9YesYes   
Xenopus tropicalisemc38 of 9YesYes   
Xenopus tropicalistmem1115 of 9NoYes   
Danio reriozgc:866099 of 10YesYes  
Danio rerioemc39 of 10YesYes  
Caenorhabditis elegansemc-39 of 9YesYes   
Saccharomyces cerevisiaeEMC39 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
Phenotype Term
Annotation details
References
abnormal neurophysiology | adult stage | somatic clone
adult midgut | somatic clone
decreased cell number | adult stage | progressive | somatic clone
endoplasmic reticulum
Golgi apparatus
increased cell number | adult stage | somatic clone
increased size | somatic clone
lethal
lethal - all die before end of first instar larval stage
photoreceptor | pupal stage
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R6
Viewer Help
10.7314M10.7315M10.7316M10.7317M10.7318M10.7319M10.7320M10.7321M10.7322M10.7323M10.7324M

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

12 interactor genes based on 14 annotations
EMC3 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
EMC1Drosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
EMC1Drosophila melanogaster
protein
  • anti tag coimmunoprecipitation
PMID:25715730
protein
EMC4Drosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
EMC2BDrosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
EMC8-9Drosophila melanogaster
protein
  • experimental knowledge based
PMID:22036573
protein
hpoDrosophila melanogaster
protein
  • anti tag coimmunoprecipitation
PMID:38031990
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Genetic Interactions

EMC3 role
EMC3 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
suppressed gene
CycEDrosophila melanogaster
suppressor gene
genetic suppression
    PMID:38031990
    suppressed gene
    Diap1Drosophila melanogaster
    suppressor gene
    genetic suppression
      PMID:38031990
      suppressor gene
      hopDrosophila melanogaster
      suppressed gene
      genetic suppression
        PMID:38031990
        suppressed gene
        hpoDrosophila melanogaster
        suppressor gene
        genetic suppression
          PMID:38031990
          suppressed gene
          MycDrosophila melanogaster
          suppressor gene
          genetic suppression
            PMID:38031990
            suppressor gene
            RafDrosophila melanogaster
            suppressed gene
            genetic suppression
              PMID:38031990
              suppressed gene
              Rpn1Drosophila melanogaster
              suppressor gene
              genetic suppression
                PMID:38031990
                suppressed gene
                ykiDrosophila melanogaster
                suppressor gene
                genetic suppression
                  PMID:38031990
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