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314 results for fkbp1b

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fkbp1b

(Danio rerio)

Gene

Name: FKBP prolyl isomerase 1B

Synonyms: si:dkeyp-115a10.1, zgc:73381

Source: ZFIN:ZDB-GENE-040426-1785

Biotype: protein coding gene

Symbol: fkbp1b (Dre)

Symbol: fkbp1b

Automated Gene Synopsis: Orthologous to human FKBP1B (FKBP prolyl isomerase 1B).

Strict Orthology Symbols: fkbp1b

Disease (4)

Fkbp1b

(Mus musculus)

Gene

Name: FK506 binding protein 1b

Synonyms: 12.6kDa, expressed sequence AW494148, calstabin2, FKBP-12.6, FKBP-1B, AW494148, FKBP12.6

Source: MGI:1336205

Biotype: protein coding gene

Symbol: Fkbp1b (Mmu)

Symbol: Fkbp1b

Automated Gene Synopsis: Orthologous to human FKBP1B (FKBP prolyl isomerase 1B).

Strict Orthology Symbols: fkbp1b

Alleles: Fkbp1b (Mmu)...Fkbp1b (Mmu)...Fkbp1b (Mmu)...Fkbp1b (Mmu)...Fkbp1b (Mmu)

FKBP1B

(Homo sapiens)

Gene

Name: FKBP prolyl isomerase 1B

Synonyms: immunophilin FKBP12.6, peptidyl-prolyl cis-trans isomerase FKBP1B, rotamase, PPIase, PKBP1L, FK506 binding protein 1B, 12.6 kDa, FK506-binding protein 1B, OTK4, h-FKBP-12, FK506 binding protein 1B, PPIase FKBP1B, 12.6 kDa FK506-binding protein, FK506-binding protein 12.6, 12.6 kDa FKBP, FK506-binding protein 1-like, FKBP-12.6, FKBP1L, FKBP-1B, calstabin 2, FKBP12.6

Source: HGNC:3712

Biotype: protein coding gene

Symbol: FKBP1B (Hsa)

Symbol: FKBP1B

Synonyms: peptidyl-prolyl cis-trans isomerase FKBP1B...PPIase FKBP1B

Strict Orthology Symbols: fkbp1b

Fkbp1b

(Rattus norvegicus)

Gene

Name: FKBP prolyl isomerase 1B

Synonyms: immunophilin FKBP12.6, peptidyl-prolyl cis-trans isomerase FKBP1B, calstabin-2, FK506 binding protein 1B, FK506 binding protein 1b (12.6 kDa), rotamase, PPIase FKBP1B, 12.6 kDa FK506-binding protein, FK506-binding protein 1B, 12.6 kDa FKBP, FKBP-1B, FKBP-12.6

Source: RGD:61835

Biotype: protein coding gene

Symbol: Fkbp1b (Rno)

Symbol: Fkbp1b

Gene Synopsis: Orthologous to human FKBP1B (FKBP prolyl isomerase 1B); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine

Automated Gene Synopsis: Orthologous to human FKBP1B (FKBP prolyl isomerase 1B).

Synonyms: peptidyl-prolyl cis-trans isomerase FKBP1B...PPIase FKBP1B

Strict Orthology Symbols: fkbp1b

fkbp1b

(Xenopus tropicalis)

Gene

Name: FKBP prolyl isomerase 1B

Synonyms: xfkbp1b, fkbp12.6, fkbp1b, pkbp1l, PPIase, otk4, FKBP prolyl isomerase 1B, fkbp1l

Source: Xenbase:XB-GENE-944316

Biotype: gene

Symbol: fkbp1b

Symbol: fkbp1b (Xtr)

Automated Gene Synopsis: Orthologous to human FKBP1B (FKBP prolyl isomerase 1B).

Synonyms: fkbp1b...fkbp1b...fkbp1b

Strict Orthology Symbols: fkbp1b

Disease (4)

fkbp1b.L

(Xenopus laevis)

Gene

Name: FKBP prolyl isomerase 1B

Synonyms: xfkbp1b, fkbp12.6, pkbp1l, PPIase, otk4, fkbp1b.L, fkbp1l, FKBP prolyl isomerase 1B

Source: Xenbase:XB-GENE-6077914

Biotype: gene

Symbol: fkbp1b.L (Xla)

Automated Gene Synopsis: Orthologous to human FKBP1B (FKBP prolyl isomerase 1B).

Strict Orthology Symbols: fkbp1b

Symbol: fkbp1b.L

Disease (1)

fkbp1b.S

(Xenopus laevis)

Gene

Name: FKBP prolyl isomerase 1B

Synonyms: xfkbp1b, fkbp12.6, pkbp1l, fkbp1b.S, PPIase, otk4, fkbp1l, FKBP prolyl isomerase 1B

Source: Xenbase:XB-GENE-17341940

Biotype: gene

Symbol: fkbp1b.S (Xla)

Automated Gene Synopsis: Orthologous to human FKBP1B (FKBP prolyl isomerase 1B).

Strict Orthology Symbols: fkbp1b

Symbol: fkbp1b.S

Disease (1)

Fkbp1b^{tm1a(EUCOMM)Hmgu}

(Mus musculus)

Allele/Variant

Source: MGI:4841973

Genes: Fkbp1b (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Fkbp1b (Mmu)

Genes: Fkbp1b (Mmu)

Symbol: Fkbp1b^{tm1a(EUCOMM)Hmgu}

Gene (1)

Fkbp1b^tm1Amks

(Mus musculus)

Allele/Variant

Source: MGI:3623214

Genes: Fkbp1b (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: catecholaminergic polymorphic ventricular tachycardia

Variant Name: Not Available

Symbol: Fkbp1b (Mmu)

Genes: Fkbp1b (Mmu)

Symbol: Fkbp1b^tm1Amks

Fkbp1b^tm1Syf

(Mus musculus)

Allele/Variant

Source: MGI:2182644

Genes: Fkbp1b (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Fkbp1b (Mmu)

Genes: Fkbp1b (Mmu)

Symbol: Fkbp1b^tm1Syf

Fkbp1b^em1Gpt

(Mus musculus)

Allele/Variant

Source: MGI:7299155

Genes: Fkbp1b (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Fkbp1b (Mmu)

Genes: Fkbp1b (Mmu)

Symbol: Fkbp1b^em1Gpt

Gene (1)

Fkbp1b^tm1Okam

(Mus musculus)

Allele/Variant

Source: MGI:3796253

Genes: Fkbp1b (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Fkbp1b (Mmu)

Genes: Fkbp1b (Mmu)

Symbol: Fkbp1b^tm1Okam

Gene (1)

Fkbp1b^tm1.1Okam

(Mus musculus)

Allele/Variant

Source: MGI:3796254

Genes: Fkbp1b (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Fkbp1b (Mmu)

Genes: Fkbp1b (Mmu)

Symbol: Fkbp1b^tm1.1Okam

Fkbp1b^{tm1b(EUCOMM)Hmgu}

(Mus musculus)

Allele/Variant

Source: MGI:5692614

Genes: Fkbp1b (Mmu)

Synonyms: Not Available

Variant Type: unreported

Molecular Consequence: Not Available

Diseases: Not Available

Variant Name: Not Available

Symbol: Fkbp1b (Mmu)

Genes: Fkbp1b (Mmu)

Symbol: Fkbp1b^{tm1b(EUCOMM)Hmgu}

FKBP1BP1

(Homo sapiens)

Gene

Name: FKBP prolyl isomerase 1B pseudogene 1

Synonyms: FK506 binding protein 1B pseudogene 1

Source: HGNC:52378

Biotype: pseudogene

Symbol: FKBP1BP1 (Hsa)

Symbol: FKBP1BP1

Fkbp1b^tm1Syf/Fkbp1b^tm1Syf [background:] either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6)

(Mus musculus)

Model

Id: MGI:3624028

Synonyms: Not Available

Symbol: Fkbp1b/Fkbp1b [background:] either: (involves: 129S/SvEv) or (involves: 129S/SvEv *

Genes: Fkbp1b (Mmu)

Alleles: Fkbp1b (Mmu)

Name: Fkbp1b/Fkbp1b [background:] either: (involves: 129S/SvEv) or (involves: 129S/SvEv *

Gene (1)

Fkbp1b^{tm1b(EUCOMM)Hmgu}/Fkbp1b^{tm1b(EUCOMM)Hmgu} [background:] C57BL/6N-Fkbp1b^{tm1b(EUCOMM)Hmgu}/BayMmucd

(Mus musculus)

Model

Id: MGI:6461272

Synonyms: Not Available

Symbol: Fkbp1b/Fkbp1b [background:] C57BL/6N-Fkbp1b/BayMmucd

Genes: Fkbp1b (Mmu)

Alleles: Fkbp1b (Mmu)

Name: Fkbp1b/Fkbp1b [background:] C57BL/6N-Fkbp1b/BayMmucd

Gene (1)

Fkbp1b^tm1Amks/Fkbp1b^tm1Amks [background:] involves: DBA/1LacJ

(Mus musculus)

Model

Id: MGI:5582596

Synonyms: Not Available

Symbol: Fkbp1b/Fkbp1b [background:] involves: DBA/1LacJ (Mmu)

Genes: Fkbp1b (Mmu)

Alleles: Fkbp1b (Mmu)

Name: Fkbp1b/Fkbp1b [background:] involves: DBA/1LacJ

Gene (1)

Fkbp1b^tm1.1Okam/Fkbp1b^tm1.1Okam [background:] ICR.129-Fkbp1b^tm1.1Okam

(Mus musculus)

Model

Id: MGI:3807881

Synonyms: Not Available

Symbol: Fkbp1b/Fkbp1b [background:] ICR.129-Fkbp1b (Mmu)

Genes: Fkbp1b (Mmu)

Alleles: Fkbp1b (Mmu)

Name: Fkbp1b/Fkbp1b [background:] ICR.129-Fkbp1b

Gene (1)

Fkbp1b^tm1Amks/Fkbp1b^tm1Amks [background:] DBA/1LacJ-Fkbp1b^tm1Amks

(Mus musculus)

Model

Id: MGI:3623679

Synonyms: Not Available

Symbol: Fkbp1b/Fkbp1b [background:] DBA/1LacJ-Fkbp1b (Mmu)

Genes: Fkbp1b (Mmu)

Alleles: Fkbp1b (Mmu)

Name: Fkbp1b/Fkbp1b [background:] DBA/1LacJ-Fkbp1b

FPR1

(Saccharomyces cerevisiae)

Gene

Name: Fk 506-sensitive Proline Rotamase

Synonyms: FKB1, RBP1, YNL135C

Source: SGD:S000005079

Biotype: protein coding gene

Automated Gene Synopsis: Orthologous to human FKBP1A (FKBP prolyl isomerase 1A); FKBP1B (FKBP prolyl isomerase 1B); and FKBP1C

Strict Orthology Symbols: fkbp1b

fkb-2

(Caenorhabditis elegans)

Gene

Name: FK506-Binding protein family 2

Synonyms: Y18D10A.19, CELE_Y18D10A.19

Source: WB:WBGene00001427

Biotype: protein coding gene

Automated Gene Synopsis: Orthologous to human FKBP1A (FKBP prolyl isomerase 1A); FKBP1B (FKBP prolyl isomerase 1B); and FKBP1C

Strict Orthology Symbols: fkbp1b

Fkbp12

(Drosophila melanogaster)

Gene

Name: FK506-binding protein 12kD

Synonyms: calstabin, FK506-BP2, FKBP12, DrFKBP12, FK506-binding protein, 143729_at, FKBP, DmFKBP12, Fk506-bp2, 11001, dFKBP12, fkbp, Calstabin, FK506-bp2, CG11001, FK506-binding protein 2

Source: FB:FBgn0013954

Biotype: protein coding gene

Strict Orthology Symbols: fkbp1b

catecholaminergic polymorphic ventricular tachycardia

Disease

Source: DOID:0060674

Definition: A heart conduction disease characterized by adrenergically induced ventricular tachycardia manifesting as syncope and sudden death during exercise, stress or catecholamine infusion without the presence of structural cardiac abnormalities.

Genes: fkbp1b (Dre)...Fkbp1b (Mmu)...Fkbp1b (Rno)...FKBP1B (Hsa)...fkbp1b (Xtr)

Alleles: Fkbp1b (Mmu)

positive regulation of sequestering of calcium ion

Gene Ontology

Source: GO:0051284

Synonyms:

activation of sequestering of calcium ion
positive regulation of calcium ion (Ca2+) retention

Branch: biological process

Genes: FKBP1B (Hsa)...Fkbp1b (Mmu)...Fkbp1b (Rno)

Genes Annotated with this GO Term (53)

cyclic nucleotide binding

Gene Ontology

Source: GO:0030551

Synonyms: Not Available

Branch: molecular function

Genes: FKBP1B (Hsa)...Fkbp1b (Mmu)...Fkbp1b (Rno)

Genes Annotated with this GO Term (165)

response to redox state

Gene Ontology

Source: GO:0051775

Synonyms:

redox signal response

Branch: biological process

Genes: Fkbp1b (Mmu)...FKBP1B (Hsa)...Fkbp1b (Rno)

Genes Annotated with this GO Term (39)

FK506 binding

Gene Ontology

Source: GO:0005528

Synonyms:

FK506-sensitive peptidyl-prolyl cis-trans isomerase

Branch: molecular function

Genes: Fkbp1b (Mmu)...Fkbp1b (Rno)...FKBP1B (Hsa)

Genes Annotated with this GO Term (21)

negative regulation of release of sequestered calcium ion into cytosol

Gene Ontology

Source: GO:0051280

Synonyms:

down regulation of release of sequestered calcium ion into cytosol
down-regulation of release of sequestered calcium ion into cytosol

Branch: biological process

Genes: Fkbp1b (Mmu)...Fkbp1b (Rno)...FKBP1B (Hsa)

Genes Annotated with this GO Term (46)

calcium channel inhibitor activity

Gene Ontology

Source: GO:0019855

Synonyms: Not Available

Branch: molecular function

Genes: Fkbp1b (Mmu)...FKBP1B (Hsa)...Fkbp1b (Rno)

Genes Annotated with this GO Term (45)

regulation of ryanodine-sensitive calcium-release channel activity

Gene Ontology

Source: GO:0060314

Synonyms: Not Available

Branch: biological process

Genes: Fkbp1b (Mmu)...FKBP1B (Hsa)...Fkbp1b (Rno)

Genes Annotated with this GO Term (60)

response to vitamin E

Gene Ontology

Source: GO:0033197

Synonyms:

response to DL-alpha-tocopherol acetate
response to DL-alpha-tocopheryl acetate

Branch: biological process

Genes: Fkbp1b (Mmu)...FKBP1B (Hsa)...Fkbp1b (Rno)

Genes Annotated with this GO Term (50)

negative regulation of calcium-mediated signaling

Gene Ontology

Source: GO:0050849

Synonyms:

down regulation of calcium-mediated signaling
down-regulation of calcium-mediated signaling

Branch: biological process

Genes: Fkbp1b (Mmu)...Fkbp1b (Rno)...FKBP1B (Hsa)

Genes Annotated with this GO Term (78)

insulin secretion involved in cellular response to glucose stimulus

Gene Ontology

Source: GO:0035773

Synonyms:

insulin secretion involved in cellular response to glucose

Branch: biological process

Genes: Fkbp1b (Mmu)...FKBP1B (Hsa)...Fkbp1b (Rno)

Genes Annotated with this GO Term (46)

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

Gene Ontology

Source: GO:0010880

Synonyms: Not Available

Branch: biological process

Genes: Fkbp1b (Mmu)...FKBP1B (Hsa)...Fkbp1b (Rno)

Genes Annotated with this GO Term (96)

negative regulation of heart rate

Gene Ontology

Source: GO:0010459

Synonyms: Not Available

Branch: biological process

Genes: Fkbp1b (Mmu)...FKBP1B (Hsa)...Fkbp1b (Rno)

Genes Annotated with this GO Term (51)

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

Gene Ontology

Source: GO:0010881

Synonyms: Not Available

Branch: biological process

Genes: Fkbp1b (Mmu)...FKBP1B (Hsa)...Fkbp1b (Rno)

Genes Annotated with this GO Term (47)

FFK506-Binding Protein 12.6/1b, a negative regulator of [Ca2+], rescues memory and restores genomic regulation in the hippocampus of aging rats

(Rattus norvegicus)

HTP Dataset Index

High-Throughput (HTP) Dataset Index metadata provided by RGD

ID: GEO:GSE102054

Tags: unclassified

Summary: Hippocampal overexpression of FK506-binding protein 12.6/1b (FKBP1b), a negative regulator of ryanodine receptor Ca2+ release, reverses aging-induced memory impairment and neuronal Ca2+ dysregulation. Here, we test the hypothesis that FKBP1b also can protect downstream transcriptional networks from aging-induced dysregulation. We gave hippocampal microinjections of FKBP1b-expressing viral vector to male rats at either 13-months-of-age (long-term) or 19-months-of-age (short-term) and tested memory performance in the Morris water maze at 21-months-of-age. Aged rats treated short- or long-term with FKBP1b substantially outperformed age-matched vector controls and performed similarly to each other and young controls. Transcriptional profiling in the same animals identified 2342 genes whose hippocampal expression was up-/down-regulated in aged controls vs. young controls (the aging effect). Of these aging-dependent genes, 876 (37%) also showed altered expression in aged FKBP1b-treated rats compared to aged controls, with FKBP1b restoring expression of essentially all such genes (872/876, 99.5%) in the direction opposite the aging effect and closer to levels in young controls. This inverse relationship between the aging and FKBP1b effects suggests that the aging effects arise from FKBP1b deficiency. Functional category analysis revealed that genes downregulated with aging and restored by FKBP1b associated predominantly with diverse brain structure categories, including cytoskeleton, membrane channels and extracellular region. Conversely, genes upregulated with aging but not restored by FKBP1b associated primarily with glial-neuroinflammatory, ribosomal and lysosomal categories. Immunohistochemistry confirmed aging-induced rarefaction, and FKBP1b-mediated restoration, of neuronal microtubular structure. Thus, a previously-unrecognized genomic network modulating diverse brain structural processes is dysregulated by aging and restored by FKBP1b overexpression.