Version: 8.1.0Date: Fri Apr 18 2025
Category
gck-3
(Caenorhabditis elegans)Gene
Name: Germinal Center Kinase family 3
Synonyms: Y59A8B.e, Y59A8B.f, CELE_Y59A8B.23, Y59A8B.23
Source: WB:WBGene00013355
Biotype: protein coding gene
Symbol: gck-3 (Cel)
Symbol: gck-3
Gene Synopsis: gck-3 encodes a STE20-related kinase, required for normal excretory canal tubules, that is regulated...by WNK-1 and in turn inhibits CLH-3; GCK-3 is expressed in oocytes and the excretory cell; GCK-3 binds...the C-terminus of CLH-3B in both two-hybrid and GST affinity assays; GCK-3 inhibits a fast gating process...constitutively activated GCK-3; and gck-3(RNAi) constitutively activates CLH-3B in immature oocytes; GCK...-3 is phosphorylated by WNK-1 in vitro, and gck-3 mutants phenotypically resemble wnk-1.
Cross References: WB:gck-3...gck-3...gck-3
OXSR1
(Homo sapiens)Gene
Name: oxidative stress responsive kinase 1
Synonyms: oxidative stress-responsive 1 protein, oxidative-stress responsive 1, OSR1, serine/threonine-protein kinase OSR1, KIAA1101, oxidative stress responsive 1
Source: HGNC:8508
Biotype: protein coding gene
Strict Orthology Symbols: gck-3
STK39
(Homo sapiens)Gene
Name: serine/threonine kinase 39
Synonyms: DKFZp686K05124, SPAK, serine/threonine-protein kinase 39, Ste20-like protein kinase, DCHT, proline-alanine-rich STE20-related kinase, serine threonine kinase 39 (STE20/SPS1 homolog, yeast), ste-20-related kinase, PASK, STE20/SPS1-related proline-alanine-rich protein kinase, STE20/SPS1 homolog, small intestine SPAK-like kinase
Source: HGNC:17717
Biotype: protein coding gene
Strict Orthology Symbols: gck-3
oxsr1a
(Danio rerio)Gene
Name: oxidative stress responsive kinase 1a
Synonyms: zgc:165661, wu:fb77f12
Source: ZFIN:ZDB-GENE-070620-25
Biotype: protein coding gene
Strict Orthology Symbols: gck-3
Oxsr1
(Mus musculus)Gene
Name: oxidative-stress responsive 1
Synonyms: Osr1, RIKEN cDNA 2810422B09 gene, expressed sequence AW209236, RIKEN cDNA 2210022N24 gene, 2210022N24Rik, AW209236, expressed sequence AI462649, AI462649, 2810422B09Rik
Source: MGI:1917378
Biotype: protein coding gene
Strict Orthology Symbols: gck-3
stk39
(Danio rerio)Gene
Name: serine threonine kinase 39
Synonyms: zmp:0000001234
Source: ZFIN:ZDB-GENE-140106-194
Biotype: protein coding gene
Strict Orthology Symbols: gck-3
Stk39
(Rattus norvegicus)Gene
Name: serine threonine kinase 39
Synonyms: serine/threonine kinase 39, STE20/SPS1 homolog (yeast), Spak, serine/threonine-protein kinase 39, Ste-20 related kinase, serine threonine kinase 39 (STE20/SPS1 homolog, yeast), serine/threonine kinase 39, STE20/SPS1 homolog, PSTK1, pancreatic serine/threonine-protein kinase, ste-20-related kinase, STE20/SPS1-related proline-alanine-rich protein kinase, PS/TK
Source: RGD:621643
Biotype: protein coding gene
Strict Orthology Symbols: gck-3
Stk39
(Mus musculus)Gene
Name: serine/threonine kinase 39
Synonyms: renal 5, Spak, SPAK, Rnl5, AW227544, DCHT, AW556857, expressed sequence AW556857, RF005, expressed sequence AW227544
Source: MGI:1858416
Biotype: protein coding gene
Strict Orthology Symbols: gck-3
oxsr1b
(Danio rerio)Gene
Name: oxidative stress responsive kinase 1b
Synonyms: zgc:55494, zgc:77321
Source: ZFIN:ZDB-GENE-040426-723
Biotype: protein coding gene
Strict Orthology Symbols: gck-3
fray
(Drosophila melanogaster)Gene
Name: frayed
Synonyms: dOSR1, Frayed, Fray, Osr1 serine/threonine-protein kinase, CG7693, dSTRAD, lag, Ste20-like protein kinase, Dosr1, STE20-like/SPAK, Ste20-like, l(3)07551, oxidative-stress-responsive kinase 1, 4624, laggard
Source: FB:FBgn0023083
Biotype: protein coding gene
Strict Orthology Symbols: gck-3
Oxsr1
(Rattus norvegicus)Gene
Name: oxidative stress responsive kinase 1
Synonyms: oxidative-stress responsive 1, LOC316064, Osr1, serine/threonine-protein kinase OSR1
Source: RGD:1310466
Biotype: protein coding gene
Strict Orthology Symbols: gck-3
oxsr1
(Xenopus tropicalis)Gene
Name: oxidative stress responsive kinase 1
Synonyms: oxidative stress responsive kinase 1, OSR1 kinase, oxsr1
Source: Xenbase:XB-GENE-5824519
Biotype: gene
Strict Orthology Symbols: gck-3
stk39
(Xenopus tropicalis)Gene
Name: serine/threonine kinase 39
Synonyms: serine/threonine kinase 39, spak, dcht, stk39, pask
Source: Xenbase:XB-GENE-1012528
Biotype: gene
Strict Orthology Symbols: gck-3
Gene Ontology
Source: GO:0060562
Synonyms: Not Available
Branch: biological process
Genes: gck-3 (Cel)
Disease
Source: DOID:0050450
Definition: A renal tubular transport disease that is has_material_basis_in mutations in genes that produce proteins involved in the kidneys' reabsorption of salt (sodium chloride or NaCl) from urine back into the bloodstream, thus impairing the kidneys' ability to reabsorb salt, leading to the loss of excess salt in the urine (salt wasting).
Genes: gck-3 (Cel)
Gene Ontology
Source: GO:0050891
Synonyms:
- body fluid osmoregulation
- multicellular organismal water homeostasis
Branch: biological process
Genes: gck-3 (Cel)
Gene Ontology
Source: GO:0006972
Synonyms:
- HOG response
- hypertonic response
Branch: biological process
Genes: gck-3 (Cel)
Gene Ontology
Source: GO:0071474
Synonyms:
- cellular HOG response
- cellular hypertonic response
Branch: biological process
Genes: gck-3 (Cel)
kbEx100
(Caenorhabditis elegans)Allele/Variant
Source: WB:WBTransgene00017743
Genes: Not Available
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Construct Regulatory Region: gck-3 (Cel)
pros-1
(Caenorhabditis elegans)Gene
Name: PROSpero homeobox homolog 1
Synonyms: CELE_K12H4.1, ceh-26, rdy-3, K12H4.1
Source: WB:WBGene00000448
Biotype: protein coding gene
Gene Synopsis: canal growth, PROS-1 functions via regulation of a number of target genes, including aqp-8, exc-5, gck
Gene Ontology
Source: GO:0051321
Synonyms:
- meiosis
Branch: biological process
Genes: gck-3 (Cel)
Gene Ontology
Source: GO:0003824
Synonyms:
- enzyme activity
Branch: molecular function
Genes: gck-3 (Cel)
Gene Ontology
Source: GO:0044024
Synonyms:
- histone kinase activity (H2A-S1 specific)
- histone serine kinase activity (H2A-S1 specific)
Branch: molecular function
Genes: gck-3 (Cel)
Gene Ontology
Source: GO:0106310
Synonyms:
- protein-serine kinase activity
Branch: molecular function
Genes: gck-3 (Cel)
Gene Ontology
Source: GO:0016310
Synonyms: Not Available
Branch: biological process
Genes: gck-3 (Cel)
Gene Ontology
Source: GO:0019901
Synonyms: Not Available
Branch: molecular function
Genes: gck-3 (Cel)
Gene Ontology
Source: GO:0007283
Synonyms:
- generation of spermatozoa
Branch: biological process
Genes: gck-3 (Cel)
Gene Ontology
Source: GO:0035556
Synonyms:
- intracellular signal transduction pathway
- intracellular signaling cascade
Branch: biological process
Genes: gck-3 (Cel)
Gene Ontology
Source: GO:0006468
Synonyms:
- protein amino acid phosphorylation
Branch: biological process
Genes: gck-3 (Cel)
Gene Ontology
Source: GO:0004674
Synonyms:
- protein serine kinase activity
- protein serine-threonine kinase activity
Branch: molecular function
Genes: gck-3 (Cel)
Gene Ontology
Source: GO:0004672
Synonyms:
- protamine kinase activity
Branch: molecular function
Genes: gck-3 (Cel)
tm1296
(Caenorhabditis elegans)Allele/Variant
Source: WB:WBVar00250300
Genes: gck-3 (Cel)
Synonyms: Not Available
Variant Type: deletion
Molecular Consequence: coding_sequence_variant, splice_donor_variant, intron_variant
Diseases: Not Available
Variant Name: Not Available
Genes: gck-3 (Cel)
Gene Ontology
Source: GO:0006338
Synonyms:
- ATP-dependent chromatin remodeling
- ATP-dependent chromatin remodelling
Branch: biological process
Genes: gck-3 (Cel)
(WBcel235)V:17961034A>G
(Caenorhabditis elegans)Allele/Variant
Source: NC_003283.11:g.17961034A>G
Genes: gck-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)V:17961034A>G
Gene Cross References: gck-3
(WBcel235)V:17961120T>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003283.11:g.17961120T>A
Genes: gck-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)V:17961120T>A
Gene Cross References: gck-3
(WBcel235)V:17961135T>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003283.11:g.17961135T>A
Genes: gck-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)V:17961135T>A
Gene Cross References: gck-3
(WBcel235)V:17961212C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003283.11:g.17961212C>T
Genes: gck-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)V:17961212C>T
Gene Cross References: gck-3
(WBcel235)V:17961474C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003283.11:g.17961474C>T
Genes: gck-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)V:17961474C>T
Gene Cross References: gck-3
(WBcel235)V:17961678C>G
(Caenorhabditis elegans)Allele/Variant
Source: NC_003283.11:g.17961678C>G
Genes: gck-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)V:17961678C>G
Gene Cross References: gck-3
(WBcel235)V:17963036C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003283.11:g.17963036C>T
Genes: gck-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)V:17963036C>T
Gene Cross References: gck-3
(WBcel235)V:17964107T>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003283.11:g.17964107T>A
Genes: gck-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)V:17964107T>A
Gene Cross References: gck-3
(WBcel235)V:17964825A>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003283.11:g.17964825A>T
Genes: gck-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)V:17964825A>T
Gene Cross References: gck-3
(WBcel235)V:17964846T>C
(Caenorhabditis elegans)Allele/Variant
Source: NC_003283.11:g.17964846T>C
Genes: gck-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)V:17964846T>C
Gene Cross References: gck-3
(WBcel235)V:17959873G>A
(Caenorhabditis elegans)Allele/Variant
Source: NC_003283.11:g.17959873G>A
Genes: gck-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)V:17959873G>A
Gene Cross References: gck-3
(WBcel235)V:17960386C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003283.11:g.17960386C>T
Genes: gck-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)V:17960386C>T
Gene Cross References: gck-3
(WBcel235)V:17960451G>C
(Caenorhabditis elegans)Allele/Variant
Source: NC_003283.11:g.17960451G>C
Genes: gck-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)V:17960451G>C
Gene Cross References: gck-3
(WBcel235)V:17960563C>G
(Caenorhabditis elegans)Allele/Variant
Source: NC_003283.11:g.17960563C>G
Genes: gck-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)V:17960563C>G
Gene Cross References: gck-3
(WBcel235)V:17962652C>T
(Caenorhabditis elegans)Allele/Variant
Source: NC_003283.11:g.17962652C>T
Genes: gck-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)V:17962652C>T
Gene Cross References: gck-3
(WBcel235)V:17963844A>G
(Caenorhabditis elegans)Allele/Variant
Source: NC_003283.11:g.17963844A>G
Genes: gck-3 (Cel)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (WBcel235)V:17963844A>G
Gene Cross References: gck-3