Version: 8.0.0Date: Tue Jan 28 2025
Category
Hltf
(Mus musculus)Gene
Name: helicase-like transcription factor
Synonyms: Snf2l3, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3, P113, SNF2 (sucrose nonfermenting, yeast, homolog)-like 3, BC057116, expressed sequence AF010600, Smarca3, cDNA sequence BC057116, AF010600
Source: MGI:1196437
Biotype: protein coding gene
Symbol: Hltf (Mmu)
Symbol: Hltf
Automated Gene Synopsis: Orthologous to human HLTF (helicase like transcription factor).
Strict Orthology Symbols: hltf
Alleles: Hltf
hltf
(Danio rerio)Gene
Name: helicase-like transcription factor
Synonyms: smarca3, wu:fc33f07
Source: ZFIN:ZDB-GENE-030131-3306
Biotype: protein coding gene
Symbol: hltf (Dre)
Symbol: hltf
Automated Gene Synopsis: Orthologous to human HLTF (helicase like transcription factor).
Strict Orthology Symbols: Hltf...HLTF
HLTF
(Homo sapiens)Gene
Name: helicase like transcription factor
Synonyms: HIP116, HLTF1, DNA-binding protein/plasminogen activator inhibitor-1 regulator, SNF2L3, SNF2-like 3, RNF80, RING-type E3 ubiquitin transferase HLTF, HIP116A, ZBU1, SMARCA3, sucrose nonfermenting protein 2-like 3, DNA-binding protein/plasminogen activator inhibitor 1 regulator, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3, RING finger protein 80, helicase-like transcription factor, sucrose nonfermenting-like 3, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3
Source: HGNC:11099
Biotype: protein coding gene
Symbol: HLTF (Hsa)
Symbol: HLTF
Synonyms: RING-type E3 ubiquitin transferase HLTF
Strict Orthology Symbols: hltf
Hltf
(Rattus norvegicus)Gene
Name: helicase-like transcription factor
Synonyms: Snf2l3, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3, LOC295568, Smarca3
Source: RGD:1309031
Biotype: protein coding gene
Symbol: Hltf (Rno)
Symbol: Hltf
Gene Synopsis: Orthologous to human HLTF (helicase like transcription factor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine
Automated Gene Synopsis: Orthologous to human HLTF (helicase like transcription factor).
Strict Orthology Symbols: hltf
HLTF-AS1
(Homo sapiens)Gene
Name: HLTF antisense RNA 1
Synonyms: RP11-464E15.4
Source: HGNC:40554
Biotype: ncRNA gene
Symbol: HLTF-AS1 (Hsa)
Symbol: HLTF-AS1
hltf
(Xenopus tropicalis)Gene
Name: helicase-like transcription factor
Synonyms: smarca3, rush1, hltf, helicase-like transcription factor
Source: Xenbase:XB-GENE-494079
Biotype: gene
Symbol: hltf (Xtr)
Symbol: hltf
Synonyms: hltf...hltf...hltf
Strict Orthology Symbols: hltf.L
hltf.L
(Xenopus laevis)Gene
Name: helicase-like transcription factor
Synonyms: smarca3, rush1, hltf.L, helicase-like transcription factor
Source: Xenbase:XB-GENE-866316
Biotype: gene
Symbol: hltf.L (Xla)
Automated Gene Synopsis: Orthologous to human HLTF (helicase like transcription factor).
Strict Orthology Symbols: hltf
Symbol: hltf.L
Hltftm1.1Geno
(Mus musculus)Allele/Variant
Source: MGI:5532312
Genes: Hltf (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hltf
Genes: Hltf (Mmu)
Symbol: Hltftm1.1Geno
Hltftm1.1Arte
(Mus musculus)Allele/Variant
Source: MGI:5484565
Genes: Hltf (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hltf
Genes: Hltf (Mmu)
Symbol: Hltftm1.1Arte
Hltftm1.1Hdin
(Mus musculus)Allele/Variant
Source: MGI:6108112
Genes: Hltf (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hltf
Genes: Hltf (Mmu)
Symbol: Hltftm1.1Hdin
Hltfem2Smoc
(Mus musculus)Allele/Variant
Source: MGI:7290224
Genes: Hltf (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hltf
Genes: Hltf (Mmu)
Symbol: Hltfem2Smoc
Hltfem1(IMPC)Bay
(Mus musculus)Allele/Variant
Source: MGI:6467481
Genes: Hltf (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hltf
Genes: Hltf (Mmu)
Symbol: Hltfem1(IMPC)Bay
Hltfem1Smoc
(Mus musculus)Allele/Variant
Source: MGI:7290223
Genes: Hltf (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hltf
Genes: Hltf (Mmu)
Symbol: Hltfem1Smoc
Hltftm1.2Geno
(Mus musculus)Allele/Variant
Source: MGI:5532313
Genes: Hltf (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hltf
Genes: Hltf (Mmu)
Symbol: Hltftm1.2Geno
Model
Id: MGI:7414917
Synonyms: Not Available
Symbol: Hltf/Hltf [background:] C57BL/6N-Hltf/BayMmucd (Mmu)
Genes: Hltf (Mmu)
Alleles: Hltf
Name: Hltf/Hltf [background:] C57BL/6N-Hltf/BayMmucd
Hltftm1.1Hdin/Hltftm1.1Hdin Shprhtm1Jhjh/Shprhtm1Jhjh [background:] involves: 129 * C57BL/6 * SJL
(Mus musculus)Model
Id: MGI:6108259
Synonyms: Not Available
Symbol: Hltf/Hltf Shprh/Shprh [background:] involves: 129 * C57BL/6
Genes: Hltf (Mmu)
Alleles: Hltf
Name: Hltf/Hltf Shprh/Shprh [background:] involves: 129 * C57BL/6
Model
Id: MGI:5532317
Synonyms: Not Available
Symbol: Hltf/Hltf [background:] B6.129S2-Hltf (Mmu)
Genes: Hltf (Mmu)
Alleles: Hltf
Name: Hltf/Hltf [background:] B6.129S2-Hltf
Hltftm1.1Hdin/Hltftm1.1Hdin ShprhGt(RRJ453)Byg/ShprhGt(RRJ453)Byg [background:] involves: 129 * C57BL/6 * SJL
(Mus musculus)Model
Id: MGI:6108258
Synonyms: Not Available
Symbol: Hltf/Hltf Shprh/Shprh [background:] involves: 129
Genes: Hltf (Mmu)
Alleles: Hltf
Name: Hltf/Hltf Shprh/Shprh [background:] involves: 129
hltfkh18/kh18
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-240327-20
Synonyms: Not Available
Symbol: hltf
Genes: hltf (Dre)
Name: hltf
Model
Id: MGI:7414916
Synonyms: Not Available
Symbol: Hltf/Hltf<+> [background:] C57BL/6N-Hltf/BayMmucd (Mmu)
Genes: Hltf (Mmu)
Alleles: Hltf
Name: Hltf/Hltf<+> [background:] C57BL/6N-Hltf/BayMmucd
Hltftm1.1Arte/Hltftm1.1Arte [background:] Not Specified
(Mus musculus)Model
Id: MGI:5484566
Synonyms: Not Available
Symbol: Hltf/Hltf [background:] Not Specified (Mmu)
Genes: Hltf (Mmu)
Alleles: Hltf
Name: Hltf/Hltf [background:] Not Specified
HltfMSN/GammMmmh
(Mus musculus)Allele/Variant
Source: MGI:6471790
Genes: Hltf (Mmu)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: Not Available
Symbol: Hltf
Genes: Hltf (Mmu)
Symbol: HltfMSN/GammMmmh
RAD5
(Saccharomyces cerevisiae)Gene
Name: RADiation sensitive
Synonyms: YLR032W, SNM2, REV2
Source: SGD:S000004022
Biotype: protein coding gene
Gene Synopsis: SCE; promotes synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; human homolog HLTF
Automated Gene Synopsis: Orthologous to human HLTF (helicase like transcription factor).
Strict Orthology Symbols: hltf
RAD16
(Saccharomyces cerevisiae)Gene
Name: RADiation sensitive
Synonyms: YBR114W, PSO5
Source: SGD:S000000318
Biotype: protein coding gene
Strict Orthology Symbols: Hltf
Source: DOID:3119
Definition: An organ system cancer located_in gastrointestinal tract that is manifested in organs of the gastrointestinal system.
Genes: Hltf (Mmu)...HLTF (Hsa)...Hltf (Rno)...hltf (Dre)
Source: GO:0016818
Synonyms: Not Available
Branch: molecular function
Genes: Hltf (Mmu)...HLTF (Hsa)...Hltf (Rno)...hltf (Dre)
kh18
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-240320-23
Genes: hltf (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: hltf (Dre)
Model
Id: MGI:6108175
Synonyms: Not Available
Genes: Hltf (Mmu)
Alleles: Hltf
Name: Apc/Apc<+> Hltf/Hltf [background:] involves: 129 * C57BL/6 * FVB/N
Symbol: Apc/Apc<+> Hltf/Hltf [background:] involves: 129 * C57BL/6 * FVB/N (Mmu)
Alternative splicing Hltf: intron retention-dependent activation of immune tolerance at the feto-maternal interface (RNA-Seq)
(Mus musculus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE114144
Tags: WT vs. mutant, genotype
Summary: Purpose: we tested the hypothesis that Hltf deletion in placenta either caused or exacerbated neonatal hypoglycemia via Hif-1alpha regulation of nutrient transporters. Methods: Individual samples [1 term placenta/sample x 5 biological replicates for test and control littermate female mice = 10 total samples] were flash frozen and sent to Otogenetics Corp. (Norcross, GA) for RNA-seq assays. Paired-end 100 nucleotide reads were aligned to genomic assembly mm10 and analyzed using the platform provided by DNAnexus, Inc. (Mountain View, CA). Results: There was no measureable evidence of uteroplacental dysfunction or fetal compromise. Conclusion: Our study is the first to show only the truncated Hltf isoform is expressed in E18.5 term placenta, and we identified a functional link between alternative splicing of Hltf and immunosuppression at the feto-maternal interface. Placental mRNA profiles of E18.5 term placenta from five wild type control and five Hltf null mouse samples were generated by deep sequencing by Illumina HiSeq2000/2500.
Symbol: Alternative splicing Hltf: intron retention-dependent activation of immune tolerance at the feto-maternal
Gene Ontology
Source: GO:0008094
Synonyms:
- ATPase activity, acting on DNA
- ATPase, acting on DNA
Branch: molecular function
Genes: Hltf (Mmu)...Hltf (Rno)...HLTF (Hsa)...hltf (Dre)
Gene Ontology
Source: GO:0042789
Synonyms:
- mRNA transcription from Pol II promoter
- mRNA transcription from RNA polymerase II promoter
Branch: biological process
Genes: Hltf (Mmu)...Hltf (Rno)...HLTF (Hsa)
Gene Ontology
Source: GO:0050767
Synonyms: Not Available
Branch: biological process
Genes: Hltf (Mmu)...HLTF (Hsa)...Hltf (Rno)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE137060
Tags: WT vs. mutant, genotype
Summary: Epigenetic silencing of HLTF in human beta cells alters insulin secretion and is associated with diabetes. Here we examine the effects of Hltf-deletion on beta cell function in genetically engineered mouse models. The developmental timeline for the exclusive expression of full-length Hltf mRNA and protein overlaps with the organization of murine pancreatic islets. Reduced insulin in the pancreatic beta cells of global Hltf-deleted near-term (E18.5) fetal mice predicts postpartum hypoinsulinemia. Seventy-five percent of newborn global Hltf-deleted postprandial mice die at a ratio of 3:2 males to females with negligible serum insulin levels, and their apoptotic beta cells are devoid of insulin. They are also hypoglycemic. Newborn beta cell-specific Hltf-deleted mice succumb to the same loss of glucose homeostasis indicating the phenotype is solely attributable to loss of beta cell function. Confirmation that an intact immune system is an absolute requirement for the phenotype resulted from breeding the Hltf-deletion into the Rag2-IL2-null background. Triple null (Hltf-/-Rag2-/-IL2-/-) newborn mice that lack functional receptors for IL-2,-4,-7,-9,-15, and -21, and have severe lymphocyte developmental impairment (deficient T and B cells, no NK cells) are euglycemic and normoinsulinemic with normal survival rates. Transcriptomic profiling (RNA-seq) eliminated beta cell-specific Hltf-deletion on gene programs essential for normal development, and beta cell secretion. Significantly, Hltf-deletion induced IL33/beta cell signaling that promoted islet infiltration of fetal CD8+T cells and beta cell apoptosis. Our data suggest, Hltf-deleted newborns that are not profoundly hypoglycemic survive in the absence of memory CD8+T cells. These Hltf-deletion studies provide mechanistic insights to how Hltf-deletion in beta cells promotes their immune destruction. We previously used RNA-seq in conjunction with 3SEQ/transcriptome to quantify expression levels in brain (14), heart (15), and placenta (7). RNase levels in pancreas are 181,000-fold higher than brain (https://www.thermofisher.com/us/en/home/references/ambion-tech-support/nuclease-enzymes/tech-notes/rnase-activity-in-mouse-tissue.html). As a result, isolation of total RNA was highly variable. Total RNA (n=47 samples) was isolated, its integrity and purity were assessed (Agilent Bioanalyzer). Ultimately pancreata (n=6 samples; 3 test (Hltf rIPCre fl/fl with low (<15 mg/dL) blood sugar, and 3 Hltf +/+ euglycemic controls) perfused in situ with RNAlater (21) using a 1 CC syringe and a 26g 1/2 needle, and snap frozen were suitable (Table 2) for rRNA-depletion. cDNA was generated from rRNA-depleted samples and subjected to Illumina library preparation. Libraries were sequenced utilizing Illumina sequencing technology. Paired-end 100 nucleotide reads were aligned to genomic assembly mm10 and analyzed using the platform provided by DNAnexus, Inc. (Mountain View, CA) to generate an unbiased gene expression analysis report of RNA-seq; alternative splicing analysis of Hltf; mutation/RNA-editing analysis and parallel comparison of expression profiles between beta cell-specific Hltf-deleted pancreata and control pancreata. The power in detecting alternative splicing was dramatically increased by paired-end sequencing relative to single-end sequencing. FPKM (fragments per kilobase of transcript per million mapped reads) were mapped against mm10 with Tophat (V1.3.3) to obtain .bam mapping files that were input into Cufflinks for transcript assembly. Cuffdiff (V 1.3.0), part of the Cufflinks package, used the alignment reads for rigorous statistical comparison of two conditions (beta cell-specific Hltf-deleted and wild type control pancreata) and 3 biological replicates for each condition. The depth of sequencing was a minimum of 20 million sequencing reads per sample [90% Power, 5% significance level: 91+/- 4% of all annotated genes are sequenced at a frequency of 0.1 times/103 bases X 3 x 109 bases/sequencing read x 3 samples = 9 x104 reads/gene]. Data were imported into iPathwayGuide (Advaita Corporation) a next-generation pathway analysis tool. Standard enrichment parameters (log fold change, logFC = 0.6, p<0.05) were used.
Gene Ontology
Source: GO:0090575
Synonyms:
- RNA polymerase II transcription factor complex
Branch: cellular component
Genes: Hltf (Mmu)...HLTF (Hsa)...Hltf (Rno)
Gene Ontology
Source: GO:0140658
Synonyms:
- ATP hydrolysis-dependent chromatin remodeler activity
- ATP-dependent chromatin remodeller activity
Branch: molecular function
Genes: hltf (Dre)
Gene Ontology
Source: GO:0004386
Synonyms:
- ATP-dependent helicase activity
Branch: molecular function
Genes: Hltf (Mmu)...HLTF (Hsa)...hltf (Dre)...Hltf (Rno)
Gene Ontology
Source: GO:0016363
Synonyms:
- nucleoskeleton
Branch: cellular component
Genes: Hltf (Mmu)...HLTF (Hsa)
Gene Ontology
Source: GO:0031625
Synonyms:
- ubiquitin ligase binding
Branch: molecular function
Genes: Hltf (Mmu)...HLTF (Hsa)...Hltf (Rno)
Gene Ontology
Source: GO:0061630
Synonyms:
- E3
- ER-associated E3 ligase
Branch: molecular function
Genes: HLTF (Hsa)...Hltf (Rno)...Hltf (Mmu)
Gene Ontology
Source: GO:0006281
Synonyms: Not Available
Branch: biological process
Genes: hltf (Dre)...Hltf (Mmu)...HLTF (Hsa)...Hltf (Rno)
Gene Ontology
Source: GO:0006325
Synonyms:
- DNA replication-independent chromatin assembly
- DNA replication-independent chromatin organization
Branch: biological process
Genes: Hltf (Mmu)...HLTF (Hsa)
Gene Ontology
Source: GO:0003676
Synonyms:
- base pairing
Branch: molecular function
Genes: hltf (Dre)...HLTF (Hsa)...Hltf (Rno)
Source: GO:0045944
Synonyms:
- activation of global transcription from RNA polymerase II promoter
- activation of transcription from RNA polymerase II promoter
Branch: biological process
Genes: Hltf (Rno)...HLTF (Hsa)...Hltf (Mmu)
sa12894
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-130411-2570
Genes: hltf (Dre)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: splice_donor_variant
Diseases: Not Available
Variant Name: Not Available
Genes: hltf (Dre)
(GRCh38)3:149068234C>T
(Homo sapiens)Allele/Variant
Source: rs41267869
Genes: HLTF (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: splice_region_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)3:149068234C>T
Gene Synonyms: RING-type E3 ubiquitin transferase HLTF
(GRCh38)3:149040123T>C
(Homo sapiens)Allele/Variant
Source: rs777075595
Genes: HLTF (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)3:149040123T>C
Gene Synonyms: RING-type E3 ubiquitin transferase HLTF
(GRCh38)3:149073247G>A
(Homo sapiens)Allele/Variant
Source: NC_000003.12:g.149073247G>A
Genes: HLTF (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (GRCh38)3:149073247G>A
Gene Synonyms: RING-type E3 ubiquitin transferase HLTF
(GRCh38)3:149039066C>A
(Homo sapiens)Allele/Variant
Source: rs775165370
Genes: HLTF (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)3:149039066C>A
Gene Synonyms: RING-type E3 ubiquitin transferase HLTF
(GRCh38)3:149039173A>G
(Homo sapiens)Allele/Variant
Source: NC_000003.12:g.149039173A>G
Genes: HLTF (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)3:149039173A>G
Gene Synonyms: RING-type E3 ubiquitin transferase HLTF
(GRCh38)3:149046208G>A
(Homo sapiens)Allele/Variant
Source: rs112020463
Genes: HLTF (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: synonymous_variant
Diseases: Not Available
Variant Name: (GRCh38)3:149046208G>A
Gene Synonyms: RING-type E3 ubiquitin transferase HLTF