Version: 8.0.0Date: Tue Jan 28 2025
Category
Hnf1a
(Mus musculus)Gene
Name: HNF1 homeobox A
Synonyms: transcription factor 1, expressed sequence AI323641, HNF1[a], LFB1, LF-B1, Lfb1, Hnf-1, Hnf1alpha, hepatocyte nuclear factor 1, HNF1, AI323641, Tcf-1, hepatic nuclear factor 1, HNF1-alpha, Tcf1
Source: MGI:98504
Biotype: protein coding gene
Symbol: Hnf1a (Mmu)
Symbol: Hnf1a
Automated Gene Synopsis: Orthologous to human HNF1A (HNF1 homeobox A).
Strict Orthology Symbols: hnf1a
Alleles: Hnf1a
HNF1A
(Homo sapiens)Gene
Name: HNF1 homeobox A
Synonyms: LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor, transcription factor 1, TCF-1, HNF1A homeobox A delta 2, interferon production regulator factor, transcription factor 1, hepatic, LFB1, truncated hepatocyte nuclear factor 1 alpha, albumin proximal factor, HNF1, liver-specific transcription factor LF-B1, IDDM20, HNF-1A, HNF-1-alpha, HNF4A, HNF1A homeobox A insIVS8, hepatic nuclear factor 1, HNF1alpha, TCF1, MODY3, hepatocyte nuclear factor 1-alpha
Source: HGNC:11621
Biotype: protein coding gene
Symbol: HNF1A (Hsa)
Symbol: HNF1A
Synonyms: HNF1A homeobox A delta 2...HNF1A homeobox A insIVS8
Strict Orthology Symbols: hnf1a
Hnf1a
(Rattus norvegicus)Gene
Name: HNF1 homeobox A
Synonyms: Transcription factor 1, hepatic, transcription factor 1, LF-B1, hepatic nuclear factor (HNF1): albumin proximal factor, also TCF1, LF-B1 hepatic nuclear factor (HNF1): albumin proximal factor also TCF1, TCF-1, Transcription factor 1 hepatic, hepatic nuclear factor-1-alpha, LF-B1, Lfb1, albumin proximal factor, HNF1, liver-specific transcription factor LF-B1, HNF-1A, HNF-1-alpha, hepatic nuclear factor 1, Tcf1, hepatocyte nuclear factor 1-alpha
Source: RGD:3828
Biotype: protein coding gene
Symbol: Hnf1a (Rno)
Symbol: Hnf1a
Gene Synopsis: Orthologous to human HNF1A (HNF1 homeobox A); PARTICIPATES IN forkhead class A signaling pathway; maturity-onset
Automated Gene Synopsis: Orthologous to human HNF1A (HNF1 homeobox A).
Strict Orthology Symbols: hnf1a
hnf1a
(Danio rerio)Gene
Name: HNF1 homeobox a
Synonyms: hnf1-a, af244934-22s, xx:af244934-22s, tcf1
Source: ZFIN:ZDB-GENE-021206-12
Biotype: protein coding gene
Symbol: hnf1a (Dre)
Symbol: hnf1a
Automated Gene Synopsis: Orthologous to human HNF1A (HNF1 homeobox A).
Strict Orthology Symbols: hnf1a
hnf1a
(Xenopus tropicalis)Gene
Name: HNF1 homeobox A
Synonyms: hnf1, HNF1 homeobox A, hnf1a-a, hnf1a-b, XLFB1a, XLFB1, XLFB1b, lfb1, hnf1a, mody3
Source: Xenbase:XB-GENE-484117
Biotype: gene
Symbol: hnf1a
Symbol: hnf1a (Xtr)
Automated Gene Synopsis: Orthologous to human HNF1A (HNF1 homeobox A).
Synonyms: hnf1a...hnf1a...hnf1a
Strict Orthology Symbols: hnf1a
HNF1A-AS1
(Homo sapiens)Gene
Name: HNF1A antisense RNA 1
Synonyms: HASTER, HAS1, C12orf27, NCRNA00262, FLJ38690
Source: HGNC:26785
Biotype: ncRNA gene
Symbol: HNF1A-AS1 (Hsa)
Symbol: HNF1A-AS1
hnf1a.L
(Xenopus laevis)Gene
Name: HNF1 homeobox A
Synonyms: hnf1, HNF1 homeobox A, hnf1a-a, hnf1a-b, XLFB1, XLFB1a, XLFB1b, lfb1, hnf1a.L, mody3
Source: Xenbase:XB-GENE-6252640
Biotype: gene
Symbol: hnf1a.L (Xla)
Automated Gene Synopsis: Orthologous to human HNF1A (HNF1 homeobox A).
Strict Orthology Symbols: hnf1a
Symbol: hnf1a.L
hnf1a.S
(Xenopus laevis)Gene
Name: HNF1 homeobox A
Synonyms: hnf1, HNF1 homeobox A, hnf1a-a, hnf1a.S, hnf1a-b, XLFB1, XLFB1a, XLFB1b, lfb1, mody3
Source: Xenbase:XB-GENE-865049
Biotype: gene
Symbol: hnf1a.S (Xla)
Automated Gene Synopsis: Orthologous to human HNF1A (HNF1 homeobox A).
Strict Orthology Symbols: hnf1a
Symbol: hnf1a.S
Hnf1aos2
(Mus musculus)Gene
Name: HNF1 homeobox A, opposite strand 2
Synonyms: Gm13825, predicted gene, OTTMUSG00000014618, OTTMUSG00000014618, predicted gene 13825, Haster
Source: MGI:3652220
Biotype: antisense lncRNA gene
Symbol: Hnf1aos2 (Mmu)
Symbol: Hnf1aos2
Hnf1aos1
(Mus musculus)Gene
Name: HNF1 homeobox A, opposite strand 1
Synonyms: predicted gene, OTTMUSG00000014613, Gm13824, OTTMUSG00000014613, Mi-Lnc70, predicted gene 13824, Haster
Source: MGI:3652225
Biotype: antisense lncRNA gene
Symbol: Hnf1aos1 (Mmu)
Symbol: Hnf1aos1
Hnf1aem1Gpt
(Mus musculus)Allele/Variant
Source: MGI:7300322
Genes: Hnf1a (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hnf1a
Genes: Hnf1a (Mmu)
Symbol: Hnf1aem1Gpt
Hnf1atm1Mya
(Mus musculus)Allele/Variant
Source: MGI:2154359
Genes: Hnf1a (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: phenylketonuria
Variant Name: Not Available
Symbol: Hnf1a
Genes: Hnf1a (Mmu)
Symbol: Hnf1atm1Mya
Hnf1atm1.1Smoc
(Mus musculus)Allele/Variant
Source: MGI:6430634
Genes: Hnf1a (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hnf1a
Genes: Hnf1a (Mmu)
Symbol: Hnf1atm1.1Smoc
Hnf1atm2Ylee
(Mus musculus)Allele/Variant
Source: MGI:2450154
Genes: Hnf1a (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hnf1a
Genes: Hnf1a (Mmu)
Symbol: Hnf1atm2Ylee
Hnf1atm2Mya
(Mus musculus)Allele/Variant
Source: MGI:2384426
Genes: Hnf1a (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hnf1a
Genes: Hnf1a (Mmu)
Symbol: Hnf1atm2Mya
Hnf1atm1.1Jfer
(Mus musculus)Allele/Variant
Source: MGI:6434289
Genes: Hnf1a (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hnf1a
Genes: Hnf1a (Mmu)
Symbol: Hnf1atm1.1Jfer
Hnf1aem1Yumia
(Mus musculus)Allele/Variant
Source: MGI:7562174
Genes: Hnf1a (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hnf1a
Genes: Hnf1a (Mmu)
Symbol: Hnf1aem1Yumia
Hnf1atm1Ylee
(Mus musculus)Allele/Variant
Source: MGI:2384427
Genes: Hnf1a (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Hnf1a
Genes: Hnf1a (Mmu)
Symbol: Hnf1atm1Ylee
Hnf1atm1.1Ylee
(Mus musculus)Allele/Variant
Source: MGI:2384429
Genes: Hnf1a (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: maturity-onset diabetes of the young type 3, type 2 diabetes mellitus
Variant Name: Not Available
Symbol: Hnf1a
Genes: Hnf1a (Mmu)
Symbol: Hnf1atm1.1Ylee
Model
Id: MGI:3610388
Synonyms: Not Available
Symbol: Hnf1a/Hnf1a [background:] involves: 129S2/SvPas (Mmu)
Genes: Hnf1a (Mmu)
Alleles: Hnf1a
Name: Hnf1a/Hnf1a [background:] involves: 129S2/SvPas
Hnf1atm1.1Ylee/Hnf1atm2Ylee Speer6-ps1Tg(Alb-cre)21Mgn/? [background:] involves: 129X1/SvJ * C57BL/6 * DBA
(Mus musculus)Model
Id: MGI:3818297
Synonyms: Not Available
Symbol: Hnf1a/Hnf1a Speer6-ps1/?
Genes: Hnf1a (Mmu)
Alleles: Hnf1a
Name: Hnf1a/Hnf1a Speer6-ps1/?
Model
Id: MGI:3818296
Synonyms: Not Available
Symbol: Hnf1a/Hnf1a [background:] involves: 129X1/SvJ * C57BL/6J (Mmu)
Genes: Hnf1a (Mmu)
Alleles: Hnf1a
Name: Hnf1a/Hnf1a [background:] involves: 129X1/SvJ * C57BL/6J
Model
Id: MGI:3843615
Synonyms: Not Available
Symbol: Hnf1a/Hnf1a [background:] involves: 129S2/SvPas (Mmu)
Genes: Hnf1a (Mmu)
Alleles: Hnf1a
Name: Hnf1a/Hnf1a [background:] involves: 129S2/SvPas
Model
Id: MGI:3623394
Synonyms: Not Available
Symbol: Hnf1a/Hnf1a [background:] involves: 129X1/SvJ * C57BL/6J (Mmu)
Genes: Hnf1a (Mmu)
Alleles: Hnf1a
Name: Hnf1a/Hnf1a [background:] involves: 129X1/SvJ * C57BL/6J
Model
Id: MGI:3818295
Synonyms: Not Available
Symbol: Hnf1a/Hnf1a [background:] involves: 129X1/SvJ * C57BL/6J (Mmu)
Genes: Hnf1a (Mmu)
Alleles: Hnf1a
Name: Hnf1a/Hnf1a [background:] involves: 129X1/SvJ * C57BL/6J
Hnf1aem1Jmer
(Mus musculus)Allele/Variant
Source: MGI:7517040
Genes: Hnf1a (Mmu)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: Not Available
Symbol: Hnf1a
Genes: Hnf1a (Mmu)
Symbol: Hnf1aem1Jmer
Source: DOID:0111102
Definition: A maturity-onset diabetes of the young that has_material_basis_in mutation in the HNF1A gene on chromosome 12q24.31.
Genes: hnf1a (Xtr)...hnf1a.L (Xla)...Hnf1a (Mmu)...HNF1A (Hsa)...hnf1a (Dre)
Alleles: Hnf1a
Disease
Source: DOID:0111366
Definition: A hepatocellular adenoma characterized by highly vascularized liver adenomas that has_material_basis_in homozygous or compound heterozygous mutation in the HNF1A gene on chromosome 12q24.31.
Genes: hnf1a (Xtr)...hnf1a.L (Xla)...Hnf1a (Mmu)...HNF1A (Hsa)...hnf1a (Dre)
Disease
Source: DOID:0110757
Definition: A type 1 diabetes mellitus that has_material_basis_in mutation of the HNF1A gene on chromosome 12q24.31.
Genes: hnf1a.L (Xla)...hnf1a (Xtr)...Hnf1a (Mmu)...HNF1A (Hsa)...hnf1a (Dre)
Source: DOID:4471
Definition: A renal cell carcinoma that has_material_basis_in chromophobe cell that appear pale when viewed under microscope, but that are larger and display different features than clear cells.
Genes: hnf1a (Xtr)...hnf1a.L (Xla)...Hnf1a (Mmu)...HNF1A (Hsa)...hnf1a (Dre)
Gene Ontology
Source: GO:0035623
Synonyms:
- glucose reabsorption
- nephron glucose absorption
Branch: biological process
Genes: Hnf1a (Mmu)...HNF1A (Hsa)...Hnf1a (Rno)
Source: DOID:0050524
Definition: A diabetes mellitus that has_material_basis_in autosomal dominant inheritance of mutations in the MODY genes impacting beta-cell function, typically occurring before 25 years of age and caused by primary insulin secretion defects.
Genes: hnf1a (Xtr)...Hnf1a (Mmu)...hnf1a (Dre)...hnf1a.L (Xla)...Hnf1a (Rno)
Gene Ontology
Source: GO:0046883
Synonyms: Not Available
Branch: biological process
Genes: Hnf1a (Mmu)...HNF1A (Hsa)...Hnf1a (Rno)
Gene Ontology
Source: GO:1903799
Synonyms:
- down regulation of gene silencing by miRNA, production of miRNAs
- down regulation of miRNA biogenesis
Branch: biological process
Genes: Hnf1a (Mmu)...Hnf1a (Rno)
Gene Ontology
Source: GO:0035565
Synonyms:
- regulation of pronephric kidney size
Branch: biological process
Genes: HNF1A (Hsa)...Hnf1a (Rno)
jh4Tg + MO1-hnf1a
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-161229-5
Synonyms: Not Available
Genes: hnf1a (Dre)
Name: jh4Tg + MO1-hnf1a
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:E-MTAB-7945
Tags: WT vs. mutant, age, genotype
Summary: HNF1A and UTX are putative tumor suppressors in pancreatic cancer. In this study, we have combined mouse genetics, transcriptomics and genome binding studies to link HNF1A and UTX in a molecular mechanism that suppresses pancreatic cancer. In this session, we have determined the transcriptome of HNF1A and UTX in the exocrine pancreas. We show that HNF1A recruits UTX to its genomic targets in pancreatic acinar cells, which results in remodeling of the chromatin landscape and activation of a broad transcriptional program of differentiated acinar cells, which in turn indirectly suppresses tumor suppressor pathways.
Symbol: RNA-seq of wild-type and Utx- or Hnf1a-deficient mouse pancreas
Gene Ontology
Source: GO:0048608
Synonyms: Not Available
Branch: biological process
Genes: Hnf1a (Mmu)...HNF1A (Hsa)...Hnf1a (Rno)
Gene Ontology
Source: GO:1902031
Synonyms:
- regulation of NAD phosphorylation and dephosphorylation
- regulation of NADP (oxidized) metabolic process
Branch: biological process
Genes: Hnf1a (Mmu)...Hnf1a (Rno)
jh1Tg; jh2Tg + CRISPR1-hnf1a
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-161229-16
Synonyms: Not Available
Genes: hnf1a (Dre)
Name: jh1Tg; jh2Tg + CRISPR1-hnf1a
Gene Ontology
Source: GO:0048341
Synonyms: Not Available
Branch: biological process
Genes: Hnf1a (Mmu)...HNF1A (Hsa)...Hnf1a (Rno)
Disease
Source: DOID:0050868
Definition: A liver benign neoplasm that is located_in liver cells and that is composed_of epithelial tissue in which tumor cells form glands or glandlike structures.
Genes: hnf1a (Xtr)...Hnf1a (Mmu)...hnf1a (Dre)...hnf1a.L (Xla)...Hnf1a (Rno)
Gene Ontology
Source: GO:0072752
Synonyms: Not Available
Branch: biological process
Genes: Hnf1a (Mmu)...Hnf1a (Rno)
jh1Tg; jh2Tg + MO1-hnf1a
(Danio rerio)Model
Id: ZFIN:ZDB-FISH-161208-36
Synonyms: Not Available
Genes: hnf1a (Dre)
Name: jh1Tg; jh2Tg + MO1-hnf1a
Disease
Source: DOID:9281
Definition: An amino acid metabolic disorder that is characterized by a mutation in the gene for the hepatic enzyme phenylalanine hydroxylase (PAH), rendering it nonfunctional.
Genes: hnf1a (Xtr)...Hnf1a (Mmu)...hnf1a (Dre)...Hnf1a (Rno)...HNF1A (Hsa)
Alleles: Hnf1a
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:E-MEXP-1709
Tags: WT vs. mutant, genotype
Summary: RNA was extracted from Hnf1a/Tcf1 (Hepatocyte Nuclear Factor 1 alpha) knockout and wild-type mouse liver fractions. Gene expression profiles were compared using Affymetrix GeneChip Mouse Genome 430 2.0 arrays [Mouse430_2].
Symbol: Transcription profiling of liver from Hnf1a-deficient and wild type mice
Gene Ontology
Source: GO:0006699
Synonyms:
- bile acid anabolism
- bile acid biosynthesis
Branch: biological process
Genes: Hnf1a (Mmu)...Hnf1a (Rno)...HNF1A (Hsa)
Gene Ontology
Source: GO:0043691
Synonyms: Not Available
Branch: biological process
Genes: Hnf1a (Mmu)...Hnf1a (Rno)...HNF1A (Hsa)
Gene Ontology
Source: GO:0030262
Synonyms:
- apoptotic nuclear change
Branch: biological process
Genes: Hnf1a (Mmu)...Hnf1a (Rno)
Gene Ontology
Source: GO:0045120
Synonyms: Not Available
Branch: cellular component
Genes: Hnf1a (Mmu)...Hnf1a (Rno)...HNF1A (Hsa)