Version: 8.0.0Date: Tue Jan 28 2025
Category
Katnal2
(Mus musculus)Gene
Name: katanin p60 subunit A-like 2
Synonyms: 3110023G01Rik, RGD1564708, RIKEN cDNA 3110023G01 gene, RIKEN cDNA 4933439B08 gene, 4933439B08Rik
Source: MGI:1924234
Biotype: protein coding gene
Symbol: Katnal2 (Mmu)
Symbol: Katnal2
Automated Gene Synopsis: Orthologous to human KATNAL2 (katanin catalytic subunit A1 like 2).
Strict Orthology Symbols: katnal2
Alleles: Katnal2
katnal2
(Danio rerio)Gene
Name: katanin p60 subunit A-like 2
Synonyms: zgc:123350
Source: ZFIN:ZDB-GENE-051113-156
Biotype: protein coding gene
Symbol: katnal2 (Dre)
Symbol: katnal2
Automated Gene Synopsis: Orthologous to human KATNAL2 (katanin catalytic subunit A1 like 2).
Strict Orthology Symbols: katnal2
KATNAL2
(Homo sapiens)Gene
Name: katanin catalytic subunit A1 like 2
Synonyms: p60 katanin-like 2, katanin p60 ATPase-containing subunit A-like 2, MGC33211, katanin p60 subunit A like 2, DKFZp667C165, katanin catalytic subunit A like 2
Source: HGNC:25387
Biotype: protein coding gene
Symbol: KATNAL2 (Hsa)
Symbol: KATNAL2
Strict Orthology Symbols: katnal2
Katnal2
(Rattus norvegicus)Gene
Name: katanin catalytic subunit A1 like 2
Synonyms: LOC307253, katanin p60 ATPase-containing subunit A-like 2, katanin p60 subunit A-like 2, similar to RIKEN cDNA 3110023G01, RGD1564708
Source: RGD:1564708
Biotype: protein coding gene
Symbol: Katnal2 (Rno)
Symbol: Katnal2
Gene Synopsis: Orthologous to human KATNAL2 (katanin catalytic subunit A1 like 2); INTERACTS WITH 17beta-estradiol;
Automated Gene Synopsis: Orthologous to human KATNAL2 (katanin catalytic subunit A1 like 2).
Strict Orthology Symbols: katnal2
katnal2
(Xenopus tropicalis)Gene
Name: katanin p60 subunit A-like 2
Synonyms: katnal2, katanin p60 subunit A-like 2
Source: Xenbase:XB-GENE-5827282
Biotype: gene
Symbol: katnal2
Symbol: katnal2 (Xtr)
Automated Gene Synopsis: Orthologous to human KATNAL2 (katanin catalytic subunit A1 like 2).
Synonyms: katnal2...katnal2...katnal2
Strict Orthology Symbols: katnal2
katnal2.L
(Xenopus laevis)Gene
Name: katanin p60 subunit A-like 2
Synonyms: katanin p60 subunit A-like 2, katnal2.L
Source: Xenbase:XB-GENE-5827303
Biotype: gene
Symbol: katnal2.L (Xla)
Automated Gene Synopsis: Orthologous to human KATNAL2 (katanin catalytic subunit A1 like 2).
Strict Orthology Symbols: katnal2
Symbol: katnal2.L
Katnal2em3Luik
(Mus musculus)Allele/Variant
Source: MGI:7618970
Genes: Katnal2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Katnal2
Genes: Katnal2 (Mmu)
Symbol: Katnal2em3Luik
Katnal2Gt(OST260791)Lex
(Mus musculus)Allele/Variant
Source: MGI:4255105
Genes: Katnal2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Katnal2
Genes: Katnal2 (Mmu)
Symbol: Katnal2Gt(OST260791)Lex
Katnal2em1Zhlu
(Mus musculus)Allele/Variant
Source: MGI:7316544
Genes: Katnal2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Katnal2
Genes: Katnal2 (Mmu)
Symbol: Katnal2em1Zhlu
Katnal2em1(IMPC)Tcp
(Mus musculus)Allele/Variant
Source: MGI:6156497
Genes: Katnal2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Katnal2
Genes: Katnal2 (Mmu)
Symbol: Katnal2em1(IMPC)Tcp
Katnal2tm1a(EUCOMM)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:4842422
Genes: Katnal2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Katnal2
Genes: Katnal2 (Mmu)
Symbol: Katnal2tm1a(EUCOMM)Wtsi
Katnal2em1Luik
(Mus musculus)Allele/Variant
Source: MGI:7618968
Genes: Katnal2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Katnal2
Genes: Katnal2 (Mmu)
Symbol: Katnal2em1Luik
Katnal2tm1c(EUCOMM)Wtsi
(Mus musculus)Allele/Variant
Source: MGI:6164199
Genes: Katnal2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Katnal2
Genes: Katnal2 (Mmu)
Symbol: Katnal2tm1c(EUCOMM)Wtsi
Katnal2em1Smoc
(Mus musculus)Allele/Variant
Source: MGI:7290642
Genes: Katnal2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Katnal2
Genes: Katnal2 (Mmu)
Symbol: Katnal2em1Smoc
Katnal2m1Anu
(Mus musculus)Allele/Variant
Source: MGI:6164198
Genes: Katnal2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Katnal2
Genes: Katnal2 (Mmu)
Symbol: Katnal2m1Anu
Katnal2em1Gpt
(Mus musculus)Allele/Variant
Source: MGI:7301084
Genes: Katnal2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Katnal2
Genes: Katnal2 (Mmu)
Symbol: Katnal2em1Gpt
Katnal2tm1c(EUCOMM)Wtsi/Katnal2tm1c(EUCOMM)Wtsi Tg(Stra8-icre)1Reb/0 [background:] involves: C57BL/6N * FVB/NJ
(Mus musculus)Model
Id: MGI:6274241
Synonyms: Not Available
Symbol: Katnal2/Katnal2 Tg(Stra8-icre)1Reb/0 [background:] involves: C57BL
Genes: Katnal2 (Mmu)
Alleles: Katnal2
Name: Katnal2/Katnal2 Tg(Stra8-icre)1Reb/0 [background:] involves: C57BL
Katnal2tm1a(EUCOMM)Wtsi/Katnal2tm1a(EUCOMM)Wtsi [background:] C57BL/6N-Katnal2tm1a(EUCOMM)Wtsi
(Mus musculus)Model
Id: MGI:6274235
Synonyms: Not Available
Symbol: Katnal2/Katnal2 [background:] C57BL/6N-Katnal2
Genes: Katnal2 (Mmu)
Alleles: Katnal2
Name: Katnal2/Katnal2 [background:] C57BL/6N-Katnal2
Katnal2em1(IMPC)Tcp/Katnal2em1(IMPC)Tcp [background:] C57BL/6N-Katnal2em1(IMPC)Tcp/Tcp
(Mus musculus)Model
Id: MGI:6408460
Synonyms: Not Available
Symbol: Katnal2/Katnal2 [background:] C57BL/6N-Katnal2/Tcp (Mmu)
Genes: Katnal2 (Mmu)
Alleles: Katnal2
Name: Katnal2/Katnal2 [background:] C57BL/6N-Katnal2/Tcp
Model
Id: MGI:6274231
Synonyms: Not Available
Symbol: Katnal2/Katnal2 [background:] C57BL/6J-Katnal2 (Mmu)
Genes: Katnal2 (Mmu)
Alleles: Katnal2
Name: Katnal2/Katnal2 [background:] C57BL/6J-Katnal2
Id: MGI:6274238
Synonyms: Not Available
Symbol: Katnal2/Katnal2 [background:] involves: C57BL/6J * C57BL/6N (Mmu)
Genes: Katnal2 (Mmu)
Alleles: Katnal2
Name: Katnal2/Katnal2 [background:] involves: C57BL/6J * C57BL/6N
Model
Id: MGI:7316546
Synonyms: Not Available
Symbol: Katnal2/Katnal2 [background:] C57BL/6-Katnal2 (Mmu)
Genes: Katnal2 (Mmu)
Alleles: Katnal2
Name: Katnal2/Katnal2 [background:] C57BL/6-Katnal2
la017392Tg
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-120806-8749
Genes: katnal2 (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: katnal2 (Dre)
Gene Ontology
Source: GO:0008568
Synonyms:
- ATP phosphohydrolase (tubulin-dimerizing)
- katanin activity
Branch: molecular function
Genes: Katnal2 (Rno)...katnal2 (Dre)...Katnal2 (Mmu)...KATNAL2 (Hsa)
Gene Ontology
Source: GO:0051013
Synonyms:
- microtubule severing activity
Branch: biological process
Genes: Katnal2 (Rno)...katnal2 (Dre)...Katnal2 (Mmu)...KATNAL2 (Hsa)
ya522
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-240514-14
Genes: katnal2 (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: katnal2 (Dre)
ya521
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-240514-13
Genes: katnal2 (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: katnal2 (Dre)
zf3701
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-240112-8
Genes: katnal2 (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: katnal2 (Dre)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE219228
Tags: WT vs. mutant, age, genotype
Summary: Autism spectrum disorders (ASD) frequently accompany macrocephaly, which could involve hydrocephalic enlargement of brain ventricles. Katnal2 is a microtubule-related protein strongly implicated in ASD. However, it remains unclear whether Katnal2 knockout (KO) in mice leads to microtubule-related cellular deficits and ASD-related phenotypes. We found here that Katnal2-KO mice display social communication deficits, including excessive courtship ultrasonic vocalizations and decreased mating success. Katnal2-KO brains show age-dependent ventricular enlargements and motile ciliary deficits in ependymal cells lining ventricular walls. Katnal2-KO hippocampal neurons, surrounded by lateral ventricles, show limited blood volumes and flow and age-dependent synaptic functional deficits involving synaptic gene downregulation and ASD-like transcriptomic changes. Early postnatal Katnal2 re-expression prevents the ventricular and behavioral phenotypes in Katnal2-KO adults. These results suggest that Katnal2 critically regulates ependymal ciliary function, ventricular volume, CSF circulation, synaptic function, and social communication and that ependymal ciliopathies could underlie ASD-related macrocephaly, ventriculomegaly, and hydrocephalus Whole brain transcriptome analysis of Katnal2 knock-out mutant and wild-type mice age of 3 and 10 weeks
Symbol: Transcriptome analysis of Katnal2 knock-out mutant and wild-type mice
Name: Transcriptome analysis of Katnal2 knock-out mutant and wild-type mice
Gene Ontology
Source: GO:0008352
Synonyms: Not Available
Branch: cellular component
Genes: KATNAL2 (Hsa)
Gene Ontology
Source: GO:0016853
Synonyms:
- other isomerase activity
Branch: molecular function
Genes: Katnal2 (Rno)...katnal2 (Dre)...KATNAL2 (Hsa)...Katnal2 (Mmu)
Gene Ontology
Source: GO:0000922
Synonyms: Not Available
Branch: cellular component
Genes: Katnal2 (Rno)...katnal2 (Dre)...KATNAL2 (Hsa)...Katnal2 (Mmu)
Gene Ontology
Source: GO:0031122
Synonyms:
- cytoplasmic microtubule organisation
- cytoplasmic microtubule organization and biogenesis
Branch: biological process
Genes: KATNAL2 (Hsa)
Gene Ontology
Source: GO:0005819
Synonyms: Not Available
Branch: cellular component
Genes: Katnal2 (Rno)...KATNAL2 (Hsa)...Katnal2 (Mmu)
Gene Ontology
Source: GO:0005874
Synonyms:
- microtubuli
- microtubulus
Branch: cellular component
Genes: Katnal2 (Mmu)...Katnal2 (Rno)...katnal2 (Dre)...KATNAL2 (Hsa)
Gene Ontology
Source: GO:0008017
Synonyms:
- microtubule severing activity
- microtubule/chromatin interaction
Branch: molecular function
Genes: Katnal2 (Mmu)...Katnal2 (Rno)...katnal2 (Dre)...KATNAL2 (Hsa)
Gene Ontology
Source: GO:0016887
Synonyms:
- ATP hydrolase activity
- ATP monophosphatase activity
Branch: molecular function
Genes: Katnal2 (Rno)...katnal2 (Dre)...KATNAL2 (Hsa)...Katnal2 (Mmu)
Gene Ontology
Source: GO:0009653
Synonyms:
- anatomical structure organization
- embryogenesis and morphogenesis
Branch: biological process
Genes: katnal2 (Dre)
sa41606
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-160601-7563
Genes: katnal2 (Dre)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: stop_gained
Diseases: Not Available
Variant Name: Not Available
Genes: katnal2 (Dre)
Gene Ontology
Source: GO:0015630
Synonyms: Not Available
Branch: cellular component
Genes: KATNAL2 (Hsa)
Gene Ontology
Source: GO:0005737
Synonyms: Not Available
Branch: cellular component
Genes: KATNAL2 (Hsa)...katnal2 (Dre)...Katnal2 (Rno)...Katnal2 (Mmu)
(GRCh38)18:47058327C>T
(Homo sapiens)Allele/Variant
Source: rs750377654
Genes: KATNAL2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)18:47058327C>T
(GRCh38)18:47067033C>T
(Homo sapiens)Allele/Variant
Source: rs1569106508
Genes: KATNAL2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)18:47067033C>T
(GRCh38)18:47077423A>C
(Homo sapiens)Allele/Variant
Source: rs112035176
Genes: KATNAL2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)18:47077423A>C
(GRCh38)18:47058303C>T
(Homo sapiens)Allele/Variant
Source: rs770499047
Genes: KATNAL2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)18:47058303C>T
(GRCh38)18:47084326C>T
(Homo sapiens)Allele/Variant
Source: rs62095457
Genes: KATNAL2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: splice_region_variant, non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)18:47084326C>T
(GRCh38)18:47098336G>T
(Homo sapiens)Allele/Variant
Source: rs140964667
Genes: KATNAL2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: stop_gained, non_coding_transcript_exon_variant, non_coding_transcript_variant, 3_prime_UTR_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)18:47098336G>T
(GRCh38)18:47099304C>T
(Homo sapiens)Allele/Variant
Source: rs374926522
Genes: KATNAL2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)18:47099304C>T
(GRCh38)18:47099331C>T
(Homo sapiens)Allele/Variant
Source: rs750752777
Genes: KATNAL2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)18:47099331C>T
(GRCh38)18:47069276C>T
(Homo sapiens)Allele/Variant
Source: rs56297904
Genes: KATNAL2 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_exon_variant, synonymous_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)18:47069276C>T