Version: 8.0.0
Date: Tue Jan 28 2025
7,645 results for lrrk1

LRRK1

(Homo sapiens)
Gene
Name: leucine rich repeat kinase 1
Synonyms: leucine-rich repeat serine/threonine-protein kinase 1, RIPK6, leucine-rich repeat kinase 1, FLJ27465, FLJ23119, OSMD, KIAA1790, Roco1
Source: HGNC:18608
Biotype: protein coding gene
Symbol: LRRK1 (Hsa)
Symbol: LRRK1
Strict Orthology Symbols: lrrk1

lrrk1

(Danio rerio)
Gene
Name: leucine-rich repeat kinase 1
Synonyms: zmp:0000000961
Source: ZFIN:ZDB-GENE-101019-2
Biotype: protein coding gene
Symbol: lrrk1 (Dre)
Symbol: lrrk1
Automated Gene Synopsis: Orthologous to human LRRK1 (leucine rich repeat kinase 1).
Strict Orthology Symbols: lrrk1

Lrrk1

(Mus musculus)
Gene
Name: leucine-rich repeat kinase 1
Synonyms: mKIAA1790, C230002E15Rik, RIKEN cDNA D130026O16 gene, AW319595, D130026O16Rik, RIKEN cDNA C230002E15 gene, expressed sequence AW319595
Source: MGI:2142227
Biotype: protein coding gene
Symbol: Lrrk1 (Mmu)
Symbol: Lrrk1
Automated Gene Synopsis: Orthologous to human LRRK1 (leucine rich repeat kinase 1).
Strict Orthology Symbols: lrrk1
Alleles: Lrrk1 (Mmu)...Lrrk1 (Mmu)...Lrrk1 (Mmu)...Lrrk1 (Mmu)...Lrrk1 (Mmu)

Lrrk1

(Rattus norvegicus)
Gene
Name: leucine-rich repeat kinase 1
Synonyms: leucine-rich repeat serine/threonine-protein kinase 1, LOC308703
Source: RGD:1308000
Biotype: protein coding gene
Symbol: Lrrk1 (Rno)
Symbol: Lrrk1
Gene Synopsis: Orthologous to human LRRK1 (leucine rich repeat kinase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine
Automated Gene Synopsis: Orthologous to human LRRK1 (leucine rich repeat kinase 1).
Strict Orthology Symbols: lrrk1
Alleles: Lrrk1 (Rno)...Lrrk1Lrrk2 (Rno)

lrrk1

(Xenopus tropicalis)
Gene
Name: leucine-rich repeat kinase 1
Synonyms: leucine-rich repeat kinase 1, lrrk1
Source: Xenbase:XB-GENE-920588
Biotype: gene
Symbol: lrrk1
Symbol: lrrk1 (Xtr)
Automated Gene Synopsis: Orthologous to human LRRK1 (leucine rich repeat kinase 1).
Synonyms: lrrk1...lrrk1...lrrk1
Strict Orthology Symbols: lrrk1

lrrk1.L

(Xenopus laevis)
Gene
Name: leucine-rich repeat kinase 1
Synonyms: lrrk1.L, leucine-rich repeat kinase 1
Source: Xenbase:XB-GENE-6252014
Biotype: gene
Symbol: lrrk1.L (Xla)
Automated Gene Synopsis: Orthologous to human LRRK1 (leucine rich repeat kinase 1).
Strict Orthology Symbols: lrrk1
Symbol: lrrk1.L

Lrrk1tm1.1Smo

(Mus musculus)
Allele/Variant
Source: MGI:5568128
Genes: Lrrk1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: osteopetrosis
Variant Name: Not Available
Symbol: Lrrk1 (Mmu)
Genes: Lrrk1 (Mmu)
Symbol: Lrrk1tm1.1Smo

Lrrk1em1Cya

(Mus musculus)
Allele/Variant
Source: MGI:7584869
Genes: Lrrk1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Lrrk1 (Mmu)
Genes: Lrrk1 (Mmu)
Symbol: Lrrk1em1Cya

Lrrk1em1SageLrrk2em1Sage

(Rattus norvegicus)
Allele/Variant
Source: RGD:7241043
Genes: Lrrk1 (Rno)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Lrrk1Lrrk2 (Rno)
Genes: Lrrk1 (Rno)
Symbol: Lrrk1em1SageLrrk2em1Sage

Lrrk1em4Gpt

(Mus musculus)
Allele/Variant
Source: MGI:7301792
Genes: Lrrk1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Lrrk1 (Mmu)
Genes: Lrrk1 (Mmu)
Symbol: Lrrk1em4Gpt

Lrrk1em2Cya

(Mus musculus)
Allele/Variant
Source: MGI:7584870
Genes: Lrrk1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Lrrk1 (Mmu)
Genes: Lrrk1 (Mmu)
Symbol: Lrrk1em2Cya

Lrrk1em1Sage

(Rattus norvegicus)
Allele/Variant
Source: RGD:7241044
Genes: Lrrk1 (Rno)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Lrrk1 (Rno)
Genes: Lrrk1 (Rno)
Symbol: Lrrk1em1Sage

Lrrk1tm1.2Ttfk

(Mus musculus)
Allele/Variant
Source: MGI:5779401
Genes: Lrrk1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Lrrk1 (Mmu)
Genes: Lrrk1 (Mmu)
Symbol: Lrrk1tm1.2Ttfk

Lrrk1tm1b(KOMP)Wtsi

(Mus musculus)
Allele/Variant
Source: MGI:5692778
Genes: Lrrk1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Lrrk1 (Mmu)
Genes: Lrrk1 (Mmu)
Symbol: Lrrk1tm1b(KOMP)Wtsi

Lrrk1tm1c(KOMP)Wtsi

(Mus musculus)
Allele/Variant
Source: MGI:5692779
Genes: Lrrk1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Lrrk1 (Mmu)
Genes: Lrrk1 (Mmu)
Symbol: Lrrk1tm1c(KOMP)Wtsi

Lrrk1tm1.1Mjff

(Mus musculus)
Allele/Variant
Source: MGI:4940302
Genes: Lrrk1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Lrrk1 (Mmu)
Genes: Lrrk1 (Mmu)
Symbol: Lrrk1tm1.1Mjff

Lrrk1tm1a(KOMP)Wtsi

(Mus musculus)
Allele/Variant
Source: MGI:4365212
Genes: Lrrk1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Lrrk1 (Mmu)
Genes: Lrrk1 (Mmu)
Symbol: Lrrk1tm1a(KOMP)Wtsi

Lrrk1em1Gpt

(Mus musculus)
Allele/Variant
Source: MGI:7376806
Genes: Lrrk1 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Lrrk1 (Mmu)
Genes: Lrrk1 (Mmu)
Symbol: Lrrk1em1Gpt

Lrrk1tm1.1Smo/Lrrk1tm1.1Smo [background:] involves: 129S/Sv

(Mus musculus)
Model
Id: MGI:5568131
Synonyms: Not Available
Symbol: Lrrk1/Lrrk1 [background:] involves: 129S/Sv (Mmu)
Genes: Lrrk1 (Mmu)
Alleles: Lrrk1 (Mmu)
Name: Lrrk1/Lrrk1 [background:] involves: 129S/Sv

Lrrk1m1Btlr/Lrrk1m1Btlr [background:] C57BL/6J-Lrrk1m1Btlr/Btlr

(Mus musculus)
Model
Id: MGI:6761475
Synonyms: Not Available
Symbol: Lrrk1/Lrrk1 [background:] C57BL/6J-Lrrk1/Btlr (Mmu)
Genes: Lrrk1 (Mmu)
Alleles: Lrrk1 (Mmu)
Name: Lrrk1/Lrrk1 [background:] C57BL/6J-Lrrk1/Btlr

Lrrk1tm1.1Mjff/Lrrk1tm1.1Mjff [background:] C57BL/6-Lrrk1tm1.1Mjff

(Mus musculus)
Model
Id: MGI:4940303
Synonyms: Not Available
Symbol: Lrrk1/Lrrk1 [background:] C57BL/6-Lrrk1 (Mmu)
Genes: Lrrk1 (Mmu)
Alleles: Lrrk1 (Mmu)
Name: Lrrk1/Lrrk1 [background:] C57BL/6-Lrrk1

Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi [background:] C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

(Mus musculus)
Model
Id: MGI:5757319
Synonyms: Not Available
Symbol: Lrrk1/Lrrk1 [background:] C57BL/6N-Lrrk1/H (Mmu)
Genes: Lrrk1 (Mmu)
Alleles: Lrrk1 (Mmu)
Name: Lrrk1/Lrrk1 [background:] C57BL/6N-Lrrk1/H

Lrrk1M2Btlr/Lrrk1+ [background:] C57BL/6J-Lrrk1m2Btlr/Btlr

(Mus musculus)
Model
Id: MGI:6761477
Synonyms: Not Available
Symbol: Lrrk1/Lrrk1<+> [background:] C57BL/6J-Lrrk1/Btlr (Mmu)
Genes: Lrrk1 (Mmu)
Alleles: Lrrk1 (Mmu)
Name: Lrrk1/Lrrk1<+> [background:] C57BL/6J-Lrrk1/Btlr

Lrrk1m1Btlr

(Mus musculus)
Allele/Variant
Source: MGI:6760630
Genes: Lrrk1 (Mmu)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: Not Available
Symbol: Lrrk1 (Mmu)
Genes: Lrrk1 (Mmu)
Symbol: Lrrk1m1Btlr

Lrrk1M2Btlr

(Mus musculus)
Allele/Variant
Source: MGI:6760631
Genes: Lrrk1 (Mmu)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: Not Available
Symbol: Lrrk1 (Mmu)
Genes: Lrrk1 (Mmu)
Symbol: Lrrk1M2Btlr

Lrrk

(Drosophila melanogaster)
Gene
Name: Leucine-rich repeat kinase
Synonyms: dLRRK2, LRRK2, dLrrk, dLrrk2, Lrrk2, dLRRK, ortholog of LRRK2, CG5483, CT17358, LRRK, lrrk
Source: FB:FBgn0038816
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to human LRRK1 (leucine rich repeat kinase 1).
Strict Orthology Symbols: Lrrk1...LRRK1

lrk-1

(Caenorhabditis elegans)
Gene
Name: Leucine-rich repeats, Ras-like domain, Kinase 1
Synonyms: LRRK2, T27C10.6, CELE_T27C10.6
Source: WB:WBGene00003068
Biotype: protein coding gene
Gene Synopsis: lrk-1 encodes the sole C. elegans homolog of the leucine-rich repeat kinases, LRRK1 and the familial
Automated Gene Synopsis: Orthologous to human LRRK1 (leucine rich repeat kinase 1).
Strict Orthology Symbols: Lrrk1...LRRK1

ALDH1A3-AS1

(Homo sapiens)
Gene
Name: ALDH1A3 antisense RNA 1
Synonyms: novel transcript, antisense to LRRK1 and ALDH1A3, uncharacterized LOC101927751, AC015712.2, LOC101927751
Source: HGNC:55416
Biotype: ncRNA gene
Synonyms: novel transcript, antisense to LRRK1 and ALDH1A3

osteosclerotic metaphyseal dysplasia

Disease
Source: DOID:0081111
Definition: A metaphyseal dysplasia that is characterized by distinctive radiographic changes, including osteosclerosis localized predominantly to the metaphyses of the long bones and that has_material_basis_in homozygous mutation in the LRRK1 gene on chromosome 15q26.
Genes: Lrrk1 (Rno)...lrrk1 (Dre)...Lrrk1 (Mmu)...LRRK1 (Hsa)...lrrk1 (Xtr)

LE-Lrrk1em1Sage-/-Lrrk2em1Sage-/-

(Rattus norvegicus)
Model
Id: RGD:7241053
Synonyms: LE-Lrrk1em1Sage-/-Lrrk2em1Sage-/-, LE-Lrrk1em1Sage-/-Lrrk2em1Sage-/-
Genes: Lrrk1 (Rno)
Alleles: Lrrk1Lrrk2 (Rno)
Name: LE-<Lrrk1Lrrk2>

LE-Lrrk1em1Sage-/-

(Rattus norvegicus)
Model
Id: RGD:7241057
Synonyms: ;LE-Lrrk1em1Sage-/Lrrk1em1Sage-, LE-Lrrk1em1Sage-/-
Genes: Lrrk1 (Rno)
Alleles: Lrrk1 (Rno)
Name: LE-<Lrrk1>

LE-Lrrk1em1Sage

(Rattus norvegicus)
Model
Id: RGD:7241051
Synonyms: LE-Lrrk1em1Sage
Genes: Lrrk1 (Rno)
Alleles: Lrrk1 (Rno)
Name: LE-<Lrrk1>

osteoclast development

Gene Ontology
Source: GO:0036035
Synonyms:
  • osteoclast cell development
Branch: biological process
Genes: Lrrk1 (Rno)...Lrrk1 (Mmu)...LRRK1 (Hsa)

positive regulation of intracellular signal transduction

Gene Ontology
Source: GO:1902533
Synonyms:
  • activation of intracellular signal transduction
  • activation of intracellular signal transduction pathway
Branch: biological process
Genes: Lrrk1 (Rno)...Lrrk1 (Mmu)...LRRK1 (Hsa)

Parkinson's disease 8

Disease
Source: DOID:0060371
Definition: A late onset Parkinson's disease that has_material_basis_in heterozygous mutation in the dardarin encoding gene on chromosome 12q12.
Genes: Lrrk1 (Rno)...Lrrk1 (Mmu)...LRRK1 (Hsa)

LE-Lrrk1em1SageLrrk2em1Sage

(Rattus norvegicus)
Model
Id: RGD:7241047
Synonyms: LEH- Lrrk1-Lrrk2tm1sage, LE-Lrrk1em1SageLrrk2em1Sage
Genes: Lrrk1 (Rno)
Alleles: Lrrk1Lrrk2 (Rno)
Name: LE-<Lrrk1Lrrk2>

osteopetrosis

Disease
Source: DOID:13533
Definition: An osteosclerosis that has_material_basis_in lack of bone resorption which results_in abnormally hard and brittle bones.
Genes: Lrrk1 (Rno)...lrrk1 (Dre)...lrrk1 (Xtr)...Lrrk1 (Mmu)...LRRK1 (Hsa)
Alleles: Lrrk1 (Mmu)

negative regulation of peptidyl-tyrosine phosphorylation

Gene Ontology
Source: GO:0050732
Synonyms:
  • down regulation of peptidyl-tyrosine phosphorylation
  • down-regulation of peptidyl-tyrosine phosphorylation
Branch: biological process
Genes: Lrrk1 (Rno)...Lrrk1 (Mmu)...LRRK1 (Hsa)

bone resorption

Gene Ontology
Source: GO:0045453
Synonyms: Not Available
Branch: biological process
Genes: Lrrk1 (Rno)...Lrrk1 (Mmu)...LRRK1 (Hsa)

late onset Parkinson's disease

Disease
Source: DOID:0060892
Definition: A Parkinson's disease characterized by onset of motor symptoms typically after 60 years of age.
Genes: Lrrk1 (Rno)...Lrrk1 (Mmu)...LRRK1 (Hsa)

peptidyl-tyrosine phosphorylation

Gene Ontology
Source: GO:0018108
Synonyms: Not Available
Branch: biological process
Genes: Lrrk1 (Rno)...Lrrk1 (Mmu)...LRRK1 (Hsa)

positive regulation of peptidyl-tyrosine phosphorylation

Gene Ontology
Source: GO:0050731
Synonyms:
  • activation of peptidyl-tyrosine phosphorylation
  • stimulation of peptidyl-tyrosine phosphorylation
Branch: biological process
Genes: Lrrk1 (Rno)...Lrrk1 (Mmu)...LRRK1 (Hsa)

regulation of signal transduction

Gene Ontology
Source: GO:0009966
Synonyms:
  • regulation of signaling pathway
  • regulation of signalling pathway
Branch: biological process
Genes: lrrk1 (Dre)...LRRK1 (Hsa)

positive regulation of canonical Wnt signaling pathway

Gene Ontology
Source: GO:0090263
Synonyms:
  • positive regulation of Wnt receptor signaling pathway through beta-catenin
  • positive regulation of canonical Wnt receptor signaling pathway
Branch: biological process
Genes: Lrrk1 (Rno)...Lrrk1 (Mmu)...LRRK1 (Hsa)

Rho-dependent protein serine/threonine kinase activity

Gene Ontology
Source: GO:0072518
Synonyms:
  • ROCK kinase activity
  • Rho-associated protein kinase activity
Branch: molecular function
Genes: lrrk1 (Dre)...Lrrk1 (Rno)...Lrrk1 (Mmu)...LRRK1 (Hsa)

histone H4S1 kinase activity

Gene Ontology
Source: GO:0044023
Synonyms:
  • histone kinase activity (H4-S1 specific)
  • histone serine kinase activity (H4-S1 specific)
Branch: molecular function
Genes: lrrk1 (Dre)...Lrrk1 (Rno)...Lrrk1 (Mmu)...LRRK1 (Hsa)

histone H3T11 kinase activity

Gene Ontology
Source: GO:0035402
Synonyms:
  • histone H3-T11 kinase activity
  • histone kinase activity (H3-T11 specific)
Branch: molecular function
Genes: lrrk1 (Dre)...Lrrk1 (Rno)...Lrrk1 (Mmu)...LRRK1 (Hsa)

3-phosphoinositide-dependent protein kinase activity

Gene Ontology
Source: GO:0004676
Synonyms:
  • PDK activity
  • phosphatidylinositol-3-phosphate protein kinase activity
Branch: molecular function
Genes: lrrk1 (Dre)...Lrrk1 (Rno)...Lrrk1 (Mmu)...LRRK1 (Hsa)

histone H3S28 kinase activity

Gene Ontology
Source: GO:0044022
Synonyms:
  • histone kinase activity (H3-S28 specific)
  • histone serine kinase activity (H3-S28 specific)
Branch: molecular function
Genes: lrrk1 (Dre)...Lrrk1 (Rno)...Lrrk1 (Mmu)...LRRK1 (Hsa)

histone H2BS36 kinase activity

Gene Ontology
Source: GO:0140823
Synonyms:
  • histone H2B-S36 kinase activity
  • histone kinase activity (H2B-S36 specific)
Branch: molecular function
Genes: lrrk1 (Dre)...Lrrk1 (Rno)...Lrrk1 (Mmu)...LRRK1 (Hsa)