Version: 8.1.0
Date: Fri Apr 18 2025
9,053 results for map3k5

MAP3K5

(Homo sapiens)
Gene
Name: mitogen-activated protein kinase kinase kinase 5
Synonyms: MEKK5, MAPK/ERK kinase kinase 5, MAPKKK5, MAP/ERK kinase kinase 5, ASK1, ASK-1, MEK kinase 5, MEKK 5, apoptosis signal regulating kinase 1, apoptosis signal-regulating kinase 1
Source: HGNC:6857
Biotype: protein coding gene
Symbol: MAP3K5 (Hsa)
Symbol: MAP3K5
Strict Orthology Symbols: map3k5

Map3k5

(Rattus norvegicus)
Gene
Name: mitogen-activated protein kinase kinase kinase 5
Synonyms: similar to apoptosis signal-regulating kinase 1, Ask1, LOC365057, apoptosis signal regulating kinase 1, RGD1306565
Source: RGD:1306565
Biotype: protein coding gene
Symbol: Map3k5 (Rno)
Symbol: Map3k5
Gene Synopsis: Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5); PARTICIPATES IN c-Jun
Automated Gene Synopsis: Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5).
Strict Orthology Symbols: Map3k5...MAP3K5

Map3k5

(Mus musculus)
Gene
Name: mitogen-activated protein kinase kinase kinase 5
Synonyms: 7420452D20Rik, Mekk5, ASK1, MEK kinase 5, Ask1, ASK, RGD1306565, RIKEN cDNA 7420452D20 gene
Source: MGI:1346876
Biotype: protein coding gene
Symbol: Map3k5 (Mmu)
Symbol: Map3k5
Automated Gene Synopsis: Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5).
Strict Orthology Symbols: map3k5
Alleles: Map3k5 (Mmu)...Map3k5 (Mmu)...Map3k5 (Mmu)...Map3k5 (Mmu)...Map3k5 (Mmu)

map3k5

(Danio rerio)
Gene
Name: mitogen-activated protein kinase kinase kinase 5
Synonyms: Ask1
Source: ZFIN:ZDB-GENE-030827-3
Biotype: protein coding gene
Symbol: map3k5 (Dre)
Symbol: map3k5
Automated Gene Synopsis: Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5).
Strict Orthology Symbols: Map3k5...MAP3K5

MAP3K5-AS2

(Homo sapiens)
Gene
Name: MAP3K5 antisense RNA 2
Synonyms: LOC101928429, uncharacterized LOC101928429
Source: HGNC:56125
Biotype: ncRNA gene
Symbol: MAP3K5-AS2 (Hsa)
Symbol: MAP3K5-AS2

MAP3K5-AS1

(Homo sapiens)
Gene
Name: MAP3K5 antisense RNA 1
Synonyms: Not Available
Source: HGNC:40358
Biotype: ncRNA gene
Symbol: MAP3K5-AS1 (Hsa)
Symbol: MAP3K5-AS1

map3k5

(Xenopus tropicalis)
Gene
Name: mitogen-activated protein kinase kinase kinase 5
Synonyms: mitogen-activated protein kinase kinase kinase 5, map3k5
Source: Xenbase:XB-GENE-1012322
Biotype: gene
Symbol: map3k5 (Xtr)
Symbol: map3k5
Synonyms: map3k5...map3k5...map3k5

Map3k5em1Cya

(Mus musculus)
Allele/Variant
Source: MGI:7794471
Genes: Map3k5 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Map3k5 (Mmu)
Genes: Map3k5 (Mmu)
Symbol: Map3k5em1Cya

Map3k5tm2.1Hijo

(Mus musculus)
Allele/Variant
Source: MGI:5617541
Genes: Map3k5 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Map3k5 (Mmu)
Genes: Map3k5 (Mmu)
Symbol: Map3k5tm2.1Hijo

Map3k5tm1a(EUCOMM)Hmgu

(Mus musculus)
Allele/Variant
Source: MGI:4434801
Genes: Map3k5 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Map3k5 (Mmu)
Genes: Map3k5 (Mmu)
Symbol: Map3k5tm1a(EUCOMM)Hmgu

Map3k5em16Gpt

(Mus musculus)
Allele/Variant
Source: MGI:7376822
Genes: Map3k5 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Map3k5 (Mmu)
Genes: Map3k5 (Mmu)
Symbol: Map3k5em16Gpt

Map3k5em2Cya

(Mus musculus)
Allele/Variant
Source: MGI:7584940
Genes: Map3k5 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Map3k5 (Mmu)
Genes: Map3k5 (Mmu)
Symbol: Map3k5em2Cya

Map3k5tm3.1Hijo

(Mus musculus)
Allele/Variant
Source: MGI:6273513
Genes: Map3k5 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Map3k5 (Mmu)
Genes: Map3k5 (Mmu)
Symbol: Map3k5tm3.1Hijo

Map3k5tm1Hijo

(Mus musculus)
Allele/Variant
Source: MGI:3046838
Genes: Map3k5 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Map3k5 (Mmu)
Genes: Map3k5 (Mmu)
Symbol: Map3k5tm1Hijo

Map3k5tm1c(EUCOMM)Hmgu

(Mus musculus)
Allele/Variant
Source: MGI:6507755
Genes: Map3k5 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Map3k5 (Mmu)
Genes: Map3k5 (Mmu)
Symbol: Map3k5tm1c(EUCOMM)Hmgu

Map3k5tm1Hijo/Map3k5tm1Hijo Map3k6tm1Hijo/Map3k6tm1Hijo [background:] B6.129-Map3k6tm1Hijo Map3k5tm1Hijo

(Mus musculus)
Model
Id: MGI:3844019
Synonyms: Not Available
Symbol: Map3k5/Map3k5 Map3k6/Map3k6 [background:] B6.129-Map3k6...Map3k5 (Mmu)
Genes: Map3k5 (Mmu)
Alleles: Map3k5 (Mmu)
Name: Map3k5/Map3k5 Map3k6/Map3k6 [background:] B6.129-Map3k6...Map3k5

Map3k5tm1Hijo/Map3k5tm1Hijo [background:] involves: 129S4/SvJae * C57BL/6J

(Mus musculus)
Model
Id: MGI:3046844
Synonyms: Not Available
Symbol: Map3k5/Map3k5 [background:] involves: 129S4/SvJae * C57BL/6J (Mmu)
Genes: Map3k5 (Mmu)
Alleles: Map3k5 (Mmu)
Name: Map3k5/Map3k5 [background:] involves: 129S4/SvJae * C57BL/6J

Map3k5tm1Hijo/Map3k5tm1Hijo [background:] B6.129S4-Map3k5tm1Hijo

(Mus musculus)
Model
Id: MGI:3046845
Synonyms: Not Available
Symbol: Map3k5/Map3k5 [background:] B6.129S4-Map3k5 (Mmu)
Genes: Map3k5 (Mmu)
Alleles: Map3k5 (Mmu)
Name: Map3k5/Map3k5 [background:] B6.129S4-Map3k5

Map3k5tm1Hijo/Map3k5tm1Hijo Raf1tm2Bacc/Raf1tm2Bacc Tg(Myh6-cre)2182Mds/0 [background:] involves: C57BL/6J

(Mus musculus)
Model
Id: MGI:3510548
Synonyms: Not Available
Symbol: Map3k5/Map3k5 Raf1/Raf1 Tg(Myh6-cre)2182Mds/0 [background:] involves
Genes: Map3k5 (Mmu)
Alleles: Map3k5 (Mmu)
Name: Map3k5/Map3k5 Raf1/Raf1 Tg(Myh6-cre)2182Mds/0 [background:] involves

Ask1

(Drosophila melanogaster)
Gene
Name: Apoptotic signal-regulating kinase 1
Synonyms: DASK1, Apoptotic signal-regulating kinase 1, DPk92B/ASK1, Protein kinase at 92B, D-ASK, dASK1, ASK1, Ask1, DASK, MEKK5/ASK1, CG4720, ask1, pk92B, Pk92B, Ask, dASK, dAsk1
Source: FB:FBgn0014006
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to several human genes including MAP3K15 (mitogen-activated protein kinase kinase kinase 15) and MAP3K5
Strict Orthology Symbols: Map3k5...MAP3K5

nsy-1

(Caenorhabditis elegans)
Gene
Name: Neuronal SYmmetry 1
Synonyms: ask-1, F59A6.1, CELE_F59A6.1, esp-8, srf-6, xts-1
Source: WB:WBGene00003822
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to several human genes including MAP3K15 (mitogen-activated protein kinase kinase kinase 15) and MAP3K5
Strict Orthology Symbols: Map3k5...MAP3K5

neuron intrinsic apoptotic signaling pathway in response to oxidative stress

Gene Ontology
Source: GO:0036480
Synonyms:
  • neuron apoptosis in response to oxidative stress
  • oxidative stress-induced neuron apoptosis
Branch: biological process
Genes: MAP3K5 (Hsa)...Map3k5 (Mmu)...Map3k5 (Rno)

cellular response to reactive nitrogen species

Gene Ontology
Source: GO:1902170
Synonyms: Not Available
Branch: biological process
Genes: MAP3K5 (Hsa)...Map3k5 (Mmu)...Map3k5 (Rno)

protein kinase complex

Gene Ontology
Source: GO:1902911
Synonyms: Not Available
Branch: cellular component
Genes: Map3k5 (Rno)...Map3k5 (Mmu)...MAP3K5 (Hsa)

IRE1-TRAF2-ASK1 complex

Gene Ontology
Source: GO:1990604
Synonyms:
  • ERN1-TRAF2-ASK1 complex
Branch: cellular component
Genes: Map3k5 (Rno)...Map3k5 (Mmu)...MAP3K5 (Hsa)

programmed necrotic cell death

Gene Ontology
Source: GO:0097300
Synonyms:
  • programmed cell death by necrosis
  • regulated necrosis
Branch: biological process
Genes: Map3k5 (Rno)...Map3k5 (Mmu)...MAP3K5 (Hsa)

intrinsic apoptotic signaling pathway in response to oxidative stress

Gene Ontology
Source: GO:0008631
Synonyms:
  • induction of apoptosis by oxidative stress
  • oxidative stress-induced intrinsic apoptotic signaling pathway
Branch: biological process
Genes: Map3k5 (Rno)...Map3k5 (Mmu)...MAP3K5 (Hsa)...map3k5 (Dre)

endothelial cell apoptotic process

Gene Ontology
Source: GO:0072577
Synonyms:
  • apoptosis of endothelial cells
  • endothelial cell apoptosis
Branch: biological process
Genes: Map3k5 (Rno)...Map3k5 (Mmu)...MAP3K5 (Hsa)

WT + MO1-map3k5

(Danio rerio)
Model
Id: ZFIN:ZDB-FISH-200420-3
Synonyms: Not Available
Genes: map3k5 (Dre)
Name: WT + MO1-map3k5

p38MAPK cascade

Gene Ontology
Source: GO:0038066
Synonyms:
  • MAPK14 cascade
  • osmosensory signaling MAPK cascade
Branch: biological process
Genes: Map3k5 (Rno)...Map3k5 (Mmu)...MAP3K5 (Hsa)...map3k5 (Dre)

JUN kinase kinase kinase activity

Gene Ontology
Source: GO:0004706
Synonyms:
  • JNK kinase kinase activity
  • JNKKK
Branch: molecular function
Genes: Map3k5 (Rno)...Map3k5 (Mmu)...MAP3K5 (Hsa)

stress-activated MAPK cascade

Gene Ontology
Source: GO:0051403
Synonyms:
  • MAPK11 cascade
  • MAPK12 cascade
Branch: biological process
Genes: Map3k5 (Rno)...Map3k5 (Mmu)...MAP3K5 (Hsa)

regulation of programmed cell death

Gene Ontology
Source: GO:0043067
Synonyms:
  • regulation of non-apoptotic programmed cell death
Branch: biological process
Genes: Map3k5 (Rno)...Map3k5 (Mmu)...MAP3K5 (Hsa)

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Gene Ontology
Source: GO:0070059
Synonyms:
  • ER stress-induced apoptosis
  • apoptosis in response to ER stress
Branch: biological process
Genes: MAP3K5 (Hsa)...map3k5 (Dre)...Map3k5 (Rno)...Map3k5 (Mmu)

positive regulation of p38MAPK cascade

Gene Ontology
Source: GO:1900745
Synonyms:
  • activation of p38 MAPK cascade
  • activation of p38 cascade
Branch: biological process
Genes: MAP3K5 (Hsa)...Map3k5 (Rno)...Map3k5 (Mmu)

MAP kinase kinase kinase activity

Gene Ontology
Source: GO:0004709
Synonyms:
  • ATP:protein phosphotransferase (MAPKKKK-activated) activity
  • MAP3K
Branch: molecular function
Genes: MAP3K5 (Hsa)...map3k5 (Dre)...Map3k5 (Rno)...Map3k5 (Mmu)

positive regulation of cardiac muscle cell apoptotic process

Gene Ontology
Source: GO:0010666
Synonyms:
  • positive regulation of cardiac muscle cell apoptosis
Branch: biological process
Genes: Map3k5 (Rno)...Map3k5 (Mmu)...MAP3K5 (Hsa)

positive regulation of JUN kinase activity

Gene Ontology
Source: GO:0043507
Synonyms:
  • positive regulation of JUNK activity
  • stimulation of JNK activity
Branch: biological process
Genes: MAP3K5 (Hsa)...Map3k5 (Rno)...Map3k5 (Mmu)

positive regulation of vascular associated smooth muscle cell proliferation

Gene Ontology
Source: GO:1904707
Synonyms:
  • activation of VSMC proliferation
  • activation of vascular smooth muscle cell proliferation
Branch: biological process
Genes: MAP3K5 (Hsa)...Map3k5 (Rno)...Map3k5 (Mmu)

perinatal necrotizing enterocolitis

Disease
Source: DOID:8677
Definition: Not Available
Genes: MAP3K5 (Hsa)...map3k5 (Dre)...Map3k5 (Rno)...Map3k5 (Mmu)

positive regulation of protein kinase activity

Gene Ontology
Source: GO:0045860
Synonyms:
  • stimulation of protein kinase activity
  • up regulation of protein kinase activity
Branch: biological process
Genes: MAP3K5 (Hsa)...Map3k5 (Rno)...Map3k5 (Mmu)

JNK cascade

Gene Ontology
Source: GO:0007254
Synonyms:
  • JNK1 cascade
  • JNK2 cascade
Branch: biological process
Genes: map3k5 (Dre)...Map3k5 (Rno)...MAP3K5 (Hsa)...Map3k5 (Mmu)

positive regulation of myoblast differentiation

Gene Ontology
Source: GO:0045663
Synonyms:
  • activation of myoblast differentiation
  • stimulation of myoblast differentiation
Branch: biological process
Genes: MAP3K5 (Hsa)...Map3k5 (Rno)...Map3k5 (Mmu)

response to ischemia

Gene Ontology
Source: GO:0002931
Synonyms: Not Available
Branch: biological process
Genes: Map3k5 (Rno)...MAP3K5 (Hsa)...Map3k5 (Mmu)

membranous glomerulonephritis

Disease
Source: DOID:10976
Definition: Not Available
Genes: Map3k5 (Rno)...MAP3K5 (Hsa)...Map3k5 (Mmu)

amphetamine abuse

Disease
Source: DOID:670
Definition: A substance abuse that involves the recurring use of amphetamines despite negative consequences.
Genes: Map3k5 (Rno)...MAP3K5 (Hsa)...Map3k5 (Mmu)

cellular response to amino acid starvation

Gene Ontology
Source: GO:0034198
Synonyms:
  • GAAC response
  • general amino acid control response
Branch: biological process
Genes: Map3k5 (Rno)...MAP3K5 (Hsa)...Map3k5 (Mmu)

cellular response to hydrogen peroxide

Gene Ontology
Source: GO:0070301
Synonyms: Not Available
Branch: biological process
Genes: Map3k5 (Rno)...MAP3K5 (Hsa)...Map3k5 (Mmu)

apoptotic signaling pathway

Gene Ontology
Source: GO:0097190
Synonyms:
  • apoptotic signalling pathway
  • induction of apoptosis by extracellular signals
Branch: biological process
Genes: Map3k5 (Rno)...MAP3K5 (Hsa)

neuron apoptotic process

Gene Ontology
Source: GO:0051402
Synonyms:
  • apoptosis of neuronal cells
  • apoptosis of neurons
Branch: biological process
Genes: map3k5 (Dre)...MAP3K5 (Hsa)...Map3k5 (Mmu)...Map3k5 (Rno)