Version: 8.2.0Date: Wed Aug 27 2025
Category
Mef2b
(Mus musculus)Gene
Name: myocyte enhancer factor 2B
Synonyms: predicted gene, 17259, AI451606, 17259, expressed sequence AI451606
Source: MGI:104526
Biotype: protein coding gene
Symbol: Mef2b (Mmu)
Symbol: Mef2b
Automated Gene Synopsis: Orthologous to several human genes including MEF2B (myocyte enhancer factor 2B).
Strict Orthology Symbols: mef2b
Alleles: Mef2b
MEF2B
(Homo sapiens)Gene
Name: myocyte enhancer factor 2B
Synonyms: RSRFR2, MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B), serum response factor-like protein 2, myocyte-specific enhancer factor 2B, FLJ32648
Source: HGNC:6995
Biotype: protein coding gene
Symbol: MEF2B (Hsa)
Symbol: MEF2B
Strict Orthology Symbols: mef2b
mef2b
(Danio rerio)Gene
Name: myocyte enhancer factor 2b
Synonyms: si:ch211-125m10.1
Source: ZFIN:ZDB-GENE-050208-357
Biotype: protein coding gene
Symbol: mef2b (Dre)
Symbol: mef2b
Automated Gene Synopsis: Orthologous to several human genes including MEF2B (myocyte enhancer factor 2B).
Strict Orthology Symbols: Mef2b...MEF2B
Mef2b
(Rattus norvegicus)Gene
Name: myocyte enhancer factor 2B
Synonyms: LOC498607, similar to Myocyte-specific enhancer factor 2B, myocyte-specific enhancer factor 2B
Source: RGD:1561733
Biotype: protein coding gene
Symbol: Mef2b (Rno)
Symbol: Mef2b
Gene Synopsis: Orthologous to several human genes including MEF2B (myocyte enhancer factor 2B); INTERACTS WITH 2,3,7,8
Automated Gene Synopsis: Orthologous to several human genes including MEF2B (myocyte enhancer factor 2B).
Strict Orthology Symbols: mef2b
Mef2bl
(Mus musculus)Gene
Name: myocyte enhancer factor 2B like
Synonyms: Gm45929, predicted gene, 45929
Source: MGI:5825566
Biotype: protein coding gene
Symbol: Mef2bl (Mmu)
Symbol: Mef2bl
Mef2bem6Gpt
(Mus musculus)Allele/Variant
Source: MGI:7302138
Genes: Mef2b (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mef2b
Genes: Mef2b (Mmu)
Symbol: Mef2bem6Gpt
Mef2btm1.1Rdf
(Mus musculus)Allele/Variant
Source: MGI:6400970
Genes: Mef2b (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mef2b
Genes: Mef2b (Mmu)
Symbol: Mef2btm1.1Rdf
Mef2btm2a(EUCOMM)Hmgu
(Mus musculus)Allele/Variant
Source: MGI:5511573
Genes: Mef2b (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mef2b
Genes: Mef2b (Mmu)
Symbol: Mef2btm2a(EUCOMM)Hmgu
Mef2btm2b(EUCOMM)Hmgu
(Mus musculus)Allele/Variant
Source: MGI:5805681
Genes: Mef2b (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Mef2b
Genes: Mef2b (Mmu)
Symbol: Mef2btm2b(EUCOMM)Hmgu
Mef2btm2Rdf/Mef2b+ Tg(BCL2/IGH)M23Tjd/0 Tg(Cr2-cre)3Cgn/0 [background:] involves: C3H/He * C57BL/6
(Mus musculus)Model
Id: MGI:6401158
Synonyms: Not Available
Symbol: Mef2b/Mef2b<+> Tg(BCL2/IGH)M23Tjd/0 Tg(Cr2-cre)3Cgn/0 [background:] involves: C3H/He * C57BL
Genes: Mef2b (Mmu)
Alleles: Mef2b
Name: Mef2b/Mef2b<+> Tg(BCL2/IGH)M23Tjd/0 Tg(Cr2-cre)3Cgn/0 [background:] involves: C3H/He * C57BL
Model
Id: MGI:6401150
Synonyms: Not Available
Symbol: Mef2b/Mef2b<+> Tg(Cr2-cre)3Cgn/0 [background:] involves: C57BL/6 (Mmu)
Genes: Mef2b (Mmu)
Alleles: Mef2b
Name: Mef2b/Mef2b<+> Tg(Cr2-cre)3Cgn/0 [background:] involves: C57BL/6
Mef2btm2b(EUCOMM)Hmgu/Mef2btm2b(EUCOMM)Hmgu [background:] C57BL/6N-Mef2btm2b(EUCOMM)Hmgu/Bay
(Mus musculus)Model
Id: MGI:6262866
Synonyms: Not Available
Symbol: Mef2b/Mef2b [background:] C57BL/6N-Mef2b/Bay (
Genes: Mef2b (Mmu)
Alleles: Mef2b
Name: Mef2b/Mef2b [background:] C57BL/6N-Mef2b/Bay
Mef2btm2Rdf
(Mus musculus)Allele/Variant
Source: MGI:6400973
Genes: Mef2b (Mmu)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: Not Available
Symbol: Mef2b
Genes: Mef2b (Mmu)
Symbol: Mef2btm2Rdf
borcs8
(Danio rerio)Gene
Name: BLOC-1 related complex subunit 8
Synonyms: si:ch211-125m10.2, mef2b, mef2bnb
Source: ZFIN:ZDB-GENE-050208-757
Biotype: protein coding gene
Synonyms: mef2b...mef2b...mef2b
BORCS8-MEF2B
(Homo sapiens)Gene
Name: BORCS8-MEF2B readthrough
Synonyms: RSRFR2, myocyte enhancer factor 2B, MEF2B, serum response factor-like protein 2, LOC729991-MEF2B, MEF2BNB-MEF2B readthrough, myocyte-specific enhancer factor 2B, LOC729991-MEF2B readthrough, MEF2BNB-MEF2B
Source: HGNC:39979
Biotype: protein coding gene
Gene Synopsis: At least one additional MEF2B variant and isoform can be expressed from a downstream promoter, and is
Synonyms: MEF2B...MEF2B
Strict Orthology Symbols: mef2b
RLM1
(Saccharomyces cerevisiae)Gene
Name: Resistance to Lethality of MKK1P386 overexpression
Synonyms: YPL089C
Source: SGD:S000006010
Biotype: protein coding gene
Automated Gene Synopsis: human genes including BORCS8-MEF2B (BORCS8-MEF2B readthrough); MEF2A (myocyte enhancer factor 2A); and MEF2B
Strict Orthology Symbols: mef2b
SMP1
(Saccharomyces cerevisiae)Gene
Name: Second MEF2-like Protein
Synonyms: YBR182C
Source: SGD:S000000386
Biotype: protein coding gene
Automated Gene Synopsis: human genes including BORCS8-MEF2B (BORCS8-MEF2B readthrough); MEF2A (myocyte enhancer factor 2A); and MEF2B
Strict Orthology Symbols: mef2b
BORCS8
(Homo sapiens)Gene
Name: BLOC-1 related complex subunit 8
Synonyms: MEF2BNB, MGC189732, MEF2B neighbor gene protein, NDOABA, FLJ32599, MGC189763, FLJ46391, AK128256, hypothetical protein LOC729991, BLOC-1-related complex subunit 8
Source: HGNC:37247
Biotype: protein coding gene
Synonyms: MEF2B neighbor gene protein
Borcs8
(Rattus norvegicus)Gene
Name: BLOC-1 related complex subunit 8
Synonyms: uncharacterized protein LOC688966, similar to K11B4.2, MEF2B neighbor, LOC688966, Mef2bnb, hypothetical protein LOC688966, BLOC-1-related complex subunit 8
Source: RGD:1582941
Biotype: protein coding gene
Synonyms: MEF2B neighbor
Mef2
(Drosophila melanogaster)Gene
Name: Myocyte enhancer factor 2
Synonyms: DMedf2, C, D-Mef2, D-MEF2, Drosophila myocyte-specific enhancer factor 2, dMEF2, dMef2, MEF-2, mef, Myocyte enhancer factor 2, mef2c, Myocyte enhancer factor-2, Dmef-2, mef2, Dmef2, BEST:SD04091, CG1429, Drosophila-myocyte enhancer factor 2, Myocyte enhancing factor 2, mef-2, Myocyte-specific enhancer factor 2, Myocyte-enhancer factor-2, MEF2, Complementation group C, l(2)46CFr, DMEF-2, DMef2, Myocyte-enhancer factor 2, Dmef, DMEF2, myocyte enhancer factor-2, dMEf2, mb247, Mef, 22.21, myocyte-specific enhancer factor 2, myocyte enhancer factor 2, Group C, SD04091, DMef-2, Myocyte Enhancing Factor 2, D-mef2, Myocyte Enhancer Factor-2, dmef2, Mef-2
Source: FB:FBgn0011656
Biotype: protein coding gene
Strict Orthology Symbols: mef2b
mef-2
(Caenorhabditis elegans)Gene
Name: related to vertebrate MEF2 transcription factor 2
Synonyms: W10D5.1, CELE_W10D5.1
Source: WB:WBGene00003182
Biotype: protein coding gene
Strict Orthology Symbols: mef2b
BORCS8P1
(Homo sapiens)Gene
Name: BORCS8 pseudogene 1
Synonyms: MEF2BNBP1, MEF2B neighbor pseudogene 1
Source: HGNC:49883
Biotype: pseudogene
Synonyms: MEF2B neighbor pseudogene 1
Ighg1tm1(cre)Cgn/0 Mef2btm1.1Rdf/Mef2btm1.1Rdf [background:] involves: 129P2/OlaHsd * C57BL/6
(Mus musculus)Model
Id: MGI:6401139
Synonyms: Not Available
Genes: Mef2b (Mmu)
Alleles: Mef2b
Name: Ighg1/0 Mef2b/Mef2b [background:] involves: 129P2/OlaHsd * C57BL/6
Symbol: Ighg1/0 Mef2b/Mef2b [background:] involves: 129P2/OlaHsd * C57BL/6
Model
Id: MGI:6401148
Synonyms: Not Available
Genes: Mef2b (Mmu)
Alleles: Mef2b
Name: Ighg1/0 Mef2b/Mef2b<+> [background:] involves: 129P2/OlaHsd * C57BL/6
Symbol: Ighg1/0 Mef2b/Mef2b<+> [background:] involves: 129P2/OlaHsd * C57BL/6 (Mmu)
la010739Tg
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-120130-659
Genes: borcs8 (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Gene Synonyms: mef2b
Ighg1tm1(cre)Cgn/0 Mef2btm1.1Rdf/Mef2b+ [background:] involves: 129P2/OlaHsd * C57BL/6
(Mus musculus)Model
Id: MGI:6401143
Synonyms: Not Available
Genes: Mef2b (Mmu)
Alleles: Mef2b
Name: Ighg1/0 Mef2b/Mef2b<+> [background:] involves: 129P2/OlaHsd * C57BL/6
Symbol: Ighg1/0 Mef2b/Mef2b<+> [background:] involves: 129P2/OlaHsd * C57BL/6 (Mmu)
Ighg1tm1(cre)Cgn/0 Mef2btm2Rdf/Mef2btm1.1Rdf [background:] involves: 129P2/OlaHsd * C57BL/6
(Mus musculus)Model
Id: MGI:6401145
Synonyms: Not Available
Genes: Mef2b (Mmu)
Alleles: Mef2b
Name: Ighg1/0 Mef2b/Mef2b [background:] involves: 129P2/OlaHsd * C57BL/6
Symbol: Ighg1/0 Mef2b/Mef2b [background:] involves: 129P2/OlaHsd * C57BL/6 (Mmu
co3012
(Danio rerio)Allele/Variant
Source: ZFIN:ZDB-ALT-231205-3
Genes: mef2b (Dre)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Genes: mef2b (Dre)
Model
Id: MGI:6401163
Synonyms: Not Available
Genes: Mef2b (Mmu)
Alleles: Mef2b
Name: Ighg1/0 Mef2b/Mef2b Mef2c/Mef2c [background:] involves
Symbol: Ighg1/0 Mef2b/Mef2b Mef2c/Mef2c [background:] involves
Source: DOID:1094
Definition: A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone and symptoms starting before seven years of age.
Genes: MEF2B (Hsa)...Mef2b (Mmu)...Mef2b (Rno)...mef2b (Dre)
Gene Ontology
Source: GO:0042826
Synonyms: Not Available
Branch: molecular function
Genes: MEF2B (Hsa)...Mef2b (Mmu)...Mef2b (Rno)...mef2b (Dre)
Gene Ontology
Source: GO:0030054
Synonyms: Not Available
Branch: cellular component
Genes: MEF2B (Hsa)...Mef2b (Mmu)...Mef2b (Rno)
Dynamic changes in E protein activity orchestrate germinal center and plasma cell development [RNA-Seq]
(Mus musculus)HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE72831
Tags: WT vs. mutant, genotype
Summary: Humoral immunity requires the generation of high-affinity antibodies, which involves the generation of germinal centres (GC) promoting class switch and affinity maturation of antigen-specific B cells, and the differentiation of long-lived plasma cells. This multi-layered process is tightly controlled by the activity of a transcriptional network including Bcl6, essential for the development of GC, and Blimp1, required for the differentiation of plasma cells. Here, we reveal an additional layer of complexity by demonstrating that dynamic changes in E-protein activity mediated by Id3 govern both GC and plasma cell differentiation. We show that down-regulation of Id3 expression in B cells in essential for releasing E2A and E2-2, the combined activity of which is required for both GC B cell and plasma cell differentiation. We demonstrate that this pathway controls the expression of multiple key factors required for antigen-induced B cell differentiation, including Blimp1, Xbp1, Mef2b and CXCR4 and is therefore critical for establishing the transcriptional network that controls GC B cell and plasma cell differentiation. Transcriptional profiling of wild type, Id3 knockout and E2A/E22 double knockout B cells using RNA sequencing
Disease
Source: DOID:1059
Definition: A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills.
Genes: Mef2b (Mmu)...Mef2b (Rno)...MEF2B (Hsa)...mef2b (Dre)
Disease
Source: DOID:0060041
Definition: A pervasive developmental disorder that is a spectrum of psychological conditions. The disease has_symptom widespread abnormalities of social interactions and communication, has_symptom severely restricted interests and has_symptom highly repetitive behavior.
Genes: Mef2b (Mmu)...Mef2b (Rno)...MEF2B (Hsa)...mef2b (Dre)
Gene Ontology
Source: GO:0046983
Synonyms: Not Available
Branch: molecular function
Genes: Mef2b (Mmu)...Mef2b (Rno)...MEF2B (Hsa)...mef2b (Dre)
Gene Ontology
Source: GO:0005667
Synonyms:
- cytoplasmic transcription factor complex
- nuclear transcription factor complex
Branch: cellular component
Genes: Mef2b (Mmu)...Mef2b (Rno)...MEF2B (Hsa)
Gene Ontology
Source: GO:0007507
Synonyms:
- cardiac development
- dorsal vessel development
Branch: biological process
Genes: Mef2b (Mmu)...Mef2b (Rno)...MEF2B (Hsa)...mef2b (Dre)
Gene Ontology
Source: GO:0007517
Synonyms: Not Available
Branch: biological process
Genes: MEF2B (Hsa)
Source: GO:0001228
Synonyms:
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in positive regulation of transcription
Branch: molecular function
Genes: Mef2b (Rno)...Mef2b (Mmu)...MEF2B (Hsa)
Source: GO:0000977
Synonyms:
- RNA polymerase II regulatory region DNA binding
Branch: molecular function
Genes: Mef2b (Rno)...mef2b (Dre)...Mef2b (Mmu)...MEF2B (Hsa)
Gene Ontology
Source: GO:0048513
Synonyms:
- development of an organ
- organogenesis
Branch: biological process
Genes: MEF2B (Hsa)
Gene Ontology
Source: GO:1990837
Synonyms:
- sequence-specific dsDNA binding
Branch: molecular function
Genes: Mef2b (Rno)...Mef2b (Mmu)...MEF2B (Hsa)
Source: GO:0000981
Synonyms:
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
Branch: molecular function
Genes: Mef2b (Rno)...MEF2B (Hsa)...mef2b (Dre)...Mef2b (Mmu)
Gene Ontology
Source: GO:0030154
Synonyms: Not Available
Branch: biological process
Genes: Mef2b (Rno)...MEF2B (Hsa)...mef2b (Dre)...Mef2b (Mmu)
(GRCh38)19:19192209C>G
(Homo sapiens)Allele/Variant
Source: rs886054308
Genes: BORCS8 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: 5_prime_UTR_variant, non_coding_transcript_exon_variant, non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)19:19192209C>G
Gene Synonyms: MEF2B neighbor gene protein
(GRCh38)19:19146797C>T
(Homo sapiens)Allele/Variant
Source: rs764313266
Genes: BORCS8-MEF2B (Hsa), MEF2B (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)19:19146797C>T
Gene Synonyms: MEF2B
(GRCh38)19:19182655C>T
(Homo sapiens)Allele/Variant
Source: rs368226313
Genes: BORCS8 (Hsa), BORCS8-MEF2B (Hsa), MEF2B (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, 5_prime_UTR_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)19:19182655C>T
Gene Synonyms: MEF2B
(GRCh38)19:19186984C>T
(Homo sapiens)Allele/Variant
Source: rs1444086918
Genes: BORCS8 (Hsa), BORCS8-MEF2B (Hsa), MEF2B (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant, non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)19:19186984C>T
Gene Synonyms: MEF2B
(GRCh38)19:19147751G>A
(Homo sapiens)Allele/Variant
Source: rs372543417
Genes: BORCS8-MEF2B (Hsa), MEF2B (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)19:19147751G>A
Gene Synonyms: MEF2B