Version: 8.0.0
Date: Tue Jan 28 2025
2,013 results for neil3

Neil3

(Mus musculus)
Gene
Name: nei like 3 (E. coli)
Synonyms: MGC:27861, MGC:36916, RGD1310562, AI449477, expressed sequence AI449477, expressed sequence C85903, BC034753, C85903, cDNA sequence BC034753
Source: MGI:2384588
Biotype: protein coding gene
Symbol: Neil3 (Mmu)
Symbol: Neil3
Automated Gene Synopsis: Orthologous to human NEIL3 (nei like DNA glycosylase 3).
Strict Orthology Symbols: neil3
Alleles: Neil3 (Mmu)...Neil3 (Mmu)...Neil3 (Mmu)...Neil3 (Mmu)...Neil3 (Mmu)

NEIL3

(Homo sapiens)
Gene
Name: nei like DNA glycosylase 3
Synonyms: nei endonuclease VIII-like 3, FGP2, FLJ10858, endonuclease 8-like 3, nei-like protein 3, NEI3, ZGRF3, hFPG2, zinc finger, GRF-type containing 3, DNA glycosylase/AP lyase Neil3, DNA glycosylase FPG2, FPG2, hNEI3, nei-like DNA glycosylase 3, endonuclease VIII-like 3, DNA glycosylase hFPG2
Source: HGNC:24573
Biotype: protein coding gene
Symbol: NEIL3 (Hsa)
Symbol: NEIL3
Gene Synopsis: NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family.
Synonyms: DNA glycosylase/AP lyase Neil3
Strict Orthology Symbols: neil3

neil3

(Danio rerio)
Gene
Name: nei-like DNA glycosylase 3
Synonyms: zgc:103553
Source: ZFIN:ZDB-GENE-041114-18
Biotype: protein coding gene
Symbol: neil3 (Dre)
Symbol: neil3
Automated Gene Synopsis: Orthologous to human NEIL3 (nei like DNA glycosylase 3).
Strict Orthology Symbols: neil3

Neil3

(Rattus norvegicus)
Gene
Name: nei-like DNA glycosylase 3
Synonyms: nei endonuclease VIII-like 3, RGD1310562, endonuclease 8-like 3, similar to putative DNA glycosylase, endonuclease VIII-like 3, nei like 3, LOC290729, nei endonuclease VIII-like 3 (E. coli), nei like 3 (E. coli)
Source: RGD:1310562
Biotype: protein coding gene
Symbol: Neil3 (Rno)
Symbol: Neil3
Gene Synopsis: Orthologous to human NEIL3 (nei like DNA glycosylase 3); PARTICIPATES IN base excision repair pathway
Automated Gene Synopsis: Orthologous to human NEIL3 (nei like DNA glycosylase 3).
Strict Orthology Symbols: neil3

neil3

(Xenopus tropicalis)
Gene
Name: nei-like DNA glycosylase 3
Synonyms: neil3, nei-like DNA glycosylase 3
Source: Xenbase:XB-GENE-1001611
Biotype: gene
Symbol: neil3
Symbol: neil3 (Xtr)
Automated Gene Synopsis: Orthologous to human NEIL3 (nei like DNA glycosylase 3).
Synonyms: neil3...neil3...neil3
Strict Orthology Symbols: neil3

neil3.L

(Xenopus laevis)
Gene
Name: nei-like DNA glycosylase 3
Synonyms: neil3.L, nei-like DNA glycosylase 3
Source: Xenbase:XB-GENE-1001617
Biotype: gene
Symbol: neil3.L (Xla)
Automated Gene Synopsis: Orthologous to human NEIL3 (nei like DNA glycosylase 3).
Strict Orthology Symbols: neil3
Symbol: neil3.L

neil3.S

(Xenopus laevis)
Gene
Name: nei-like DNA glycosylase 3
Synonyms: nei-like DNA glycosylase 3, neil3.S
Source: Xenbase:XB-GENE-17342803
Biotype: gene
Symbol: neil3.S (Xla)
Automated Gene Synopsis: Orthologous to human NEIL3 (nei like DNA glycosylase 3).
Strict Orthology Symbols: neil3
Symbol: neil3.S

Neil3em9Gpt

(Mus musculus)
Allele/Variant
Source: MGI:7302931
Genes: Neil3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Neil3 (Mmu)
Genes: Neil3 (Mmu)
Symbol: Neil3em9Gpt

Neil3tm1Yun

(Mus musculus)
Allele/Variant
Source: MGI:3521920
Genes: Neil3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Neil3 (Mmu)
Genes: Neil3 (Mmu)
Symbol: Neil3tm1Yun

Neil3em1Smoc

(Mus musculus)
Allele/Variant
Source: MGI:7291281
Genes: Neil3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Neil3 (Mmu)
Genes: Neil3 (Mmu)
Symbol: Neil3em1Smoc

Neil3em1Gpt

(Mus musculus)
Allele/Variant
Source: MGI:7462222
Genes: Neil3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Neil3 (Mmu)
Genes: Neil3 (Mmu)
Symbol: Neil3em1Gpt

Neil3tm1Bjor

(Mus musculus)
Allele/Variant
Source: MGI:5306033
Genes: Neil3 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Neil3 (Mmu)
Genes: Neil3 (Mmu)
Symbol: Neil3tm1Bjor

Neil3tm1Yun/Neil3tm1Yun [background:] involves: 129S/SvEv * C57BL/6J

(Mus musculus)
Model
Id: MGI:3838150
Synonyms: Not Available
Symbol: Neil3/Neil3 [background:] involves: 129S/SvEv * C57BL/6J (Mmu)
Genes: Neil3 (Mmu)
Alleles: Neil3 (Mmu)
Name: Neil3/Neil3 [background:] involves: 129S/SvEv * C57BL/6J

Neil3tm1Bjor/Neil3tm1Bjor [background:] involves: 129 * C57BL/6

(Mus musculus)
Model
Id: MGI:5306040
Synonyms: Not Available
Symbol: Neil3/Neil3 [background:] involves: 129 * C57BL/6 (Mmu)
Genes: Neil3 (Mmu)
Alleles: Neil3 (Mmu)
Name: Neil3/Neil3 [background:] involves: 129 * C57BL/6

MCM complex binding

Gene Ontology
Source: GO:1904931
Synonyms:
  • mini-chromosome maintenance complex binding
Branch: molecular function
Genes: NEIL3 (Hsa)...Neil3 (Mmu)

DNA N-glycosylase activity

Gene Ontology
Source: GO:0019104
Synonyms:
  • DNA glycosylase activity
  • endonuclease VIII activity
Branch: molecular function
Genes: NEIL3 (Hsa)...Neil3 (Mmu)...neil3 (Dre)...Neil3 (Rno)

bubble DNA binding

Gene Ontology
Source: GO:0000405
Synonyms: Not Available
Branch: molecular function
Genes: NEIL3 (Hsa)...Neil3 (Mmu)...Neil3 (Rno)

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

Gene Ontology
Source: GO:0140078
Synonyms:
  • AP endonuclease class I activity
  • AP lyase activity
Branch: molecular function
Genes: NEIL3 (Hsa)...Neil3 (Mmu)...neil3 (Dre)...Neil3 (Rno)

Neuronal development in NEIL3-deficient mice (hippocampus)

(Mus musculus)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE161074
Tags: WT vs. mutant, age, genotype
Summary: brain tissue from all subregions (CA1, CA3, dentate gyrus) of the hippocampal formation was isolated at postnatal day 8 and at an adult age (3-6months old animals) in wildtype and NEIL3-deficient mice (n=4 at p8 and n=3 at adult age). NEILs are DNA glycosylases potentially involved in transcription regulation and hippocampal neuronal maturation. RNA was extracted and sequenced. Wildtype (C57Bl6) and mice deficient in NEIL3 (C57Bl6-background) were used. Tissue was isolated exclusively at baseline, i.e. the animal was taken directly from its homecage without any behavioral intervention
Symbol: Neuronal development in NEIL3-deficient mice (hippocampus)

DNA-(apurinic or apyrimidinic site) endonuclease activity

Gene Ontology
Source: GO:0003906
Synonyms:
  • AP deoxyendoribonuclease activity
  • UV endonuclease
Branch: molecular function
Genes: Neil3 (Mmu)...neil3 (Dre)...NEIL3 (Hsa)...Neil3 (Rno)

single strand break repair

Gene Ontology
Source: GO:0000012
Synonyms: Not Available
Branch: biological process
Genes: NEIL3 (Hsa)...Neil3 (Mmu)...Neil3 (Rno)

neuronal development in NEIL3-deficient mice (hippocampus) [DG]

(Mus musculus)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE175360
Tags: WT vs. mutant, age, genotype
Summary: brain tissue from Dentate Gyrus subregion of the hippocampal formation was isolated at postnatal day 8 and at an adult age (3-6 months old animals) in wildtype and NEIL3-deficient mice (n=4 at p8 and n=3 at adult age). NEILs are DNA glycosylases potentially involved in transcription regulation and hippocampal neuronal maturation. RNA was extracted and sequenced. Wildtype (C57Bl6) and mice deficient in NEIL3 (C57Bl6-background) were used. Tissue was isolated exclusively at baseline, i.e. the animal was taken directly from its homecage without any behavioral intervention
Symbol: neuronal development in NEIL3-deficient mice (hippocampus) [DG]

Neuronal development in NEIL3-deficient mice (hippocampus) [CA1]

(Mus musculus)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE175358
Tags: WT vs. mutant, age, genotype
Summary: brain tissue from CA1 subregion of the hippocampal formation was isolated at postnatal day 8 and at an adult age (3-6 months old animals) in wildtype and NEIL3-deficient mice (n=4 at p8 and n=3 at adult age). NEILs are DNA glycosylases potentially involved in transcription regulation and hippocampal neuronal maturation. RNA was extracted and sequenced. Wildtype (C57Bl6) and mice deficient in NEIL3 (C57Bl6-background) were used. Tissue was isolated exclusively at baseline, i.e. the animal was taken directly from its homecage without any behavioral intervention
Symbol: Neuronal development in NEIL3-deficient mice (hippocampus) [CA1]

depurination

Gene Ontology
Source: GO:0045007
Synonyms: Not Available
Branch: biological process
Genes: NEIL3 (Hsa)

Neuronal development in NEIL3-deficient mice (hippocampus) [CA3]

(Mus musculus)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE175359
Tags: WT vs. mutant, age, genotype
Summary: brain tissue from CA3 subregion of the hippocampal formation was isolated at postnatal day 8 and at an adult age (3-6 months old animals) in wildtype and NEIL3-deficient mice (n=4 at p8 and n=3 at adult age). NEILs are DNA glycosylases potentially involved in transcription regulation and hippocampal neuronal maturation. RNA was extracted and sequenced. Wildtype (C57Bl6) and mice deficient in NEIL3 (C57Bl6-background) were used. Tissue was isolated exclusively at baseline, i.e. the animal was taken directly from its homecage without any behavioral intervention
Symbol: Neuronal development in NEIL3-deficient mice (hippocampus) [CA3]

Transcriptome after spatial exploration in CA1-specific brain tissue from wildtype and NEIL3-deficient mice

(Mus musculus)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE148408
Tags: WT vs. mutant, genotype
Summary: CA1-specific brain tissue from the hippocampal formation was isolated at baseline (homecage condition) and after a spatial exploration paradigm ("open field") in wildtype and NEIL3-deficient mice. NEIL3 is a DNA glycosylase potentially involved in transcription regulation. RNA was extracted and sequenced. Subsequently, these results were correlated to an extracellular live recording of pyramidal cell activity ("place cell recording") in the same genotypes. Wildtype (C57Bl6) and NEIL3-deficient (Neil3-/-, C57Bl6-background) were used. At baseline, 2 wildtype and 2 mutant animals were included. After learning, 3 wildtype and 3 mutant animals were included. In both conditions, animals were exposed to the same housing conditions, food ad libitum and handled by the same experimenters.
Symbol: Transcriptome after spatial exploration in CA1-specific brain tissue from wildtype and NEIL3-deficient

base-excision repair, AP site formation

Gene Ontology
Source: GO:0006285
Synonyms: Not Available
Branch: biological process
Genes: NEIL3 (Hsa)

base-excision repair

Gene Ontology
Source: GO:0006284
Synonyms:
  • BER
Branch: biological process
Genes: Neil3 (Mmu)...neil3 (Dre)...NEIL3 (Hsa)...Neil3 (Rno)

hydrolase activity, hydrolyzing N-glycosyl compounds

Gene Ontology
Source: GO:0016799
Synonyms: Not Available
Branch: molecular function
Genes: neil3 (Dre)

damaged DNA binding

Gene Ontology
Source: GO:0003684
Synonyms:
  • DNA repair enzyme
  • DNA repair protein
Branch: molecular function
Genes: neil3 (Dre)...Neil3 (Rno)...Neil3 (Mmu)...NEIL3 (Hsa)

interstrand cross-link repair

Gene Ontology
Source: GO:0036297
Synonyms:
  • ICL repair
Branch: biological process
Genes: Neil3 (Mmu)...NEIL3 (Hsa)

hydrolase activity, acting on glycosyl bonds

Gene Ontology
Source: GO:0016798
Synonyms:
  • N-glycosylase
  • glycosidase activity
Branch: molecular function
Genes: neil3 (Dre)...NEIL3 (Hsa)

double-stranded DNA binding

Gene Ontology
Source: GO:0003690
Synonyms:
  • dsDNA binding
Branch: molecular function
Genes: Neil3 (Rno)...Neil3 (Mmu)...NEIL3 (Hsa)

single-stranded DNA binding

Gene Ontology
Source: GO:0003697
Synonyms:
  • ssDNA binding
Branch: molecular function
Genes: Neil3 (Rno)...Neil3 (Mmu)...NEIL3 (Hsa)

nuclease activity

Gene Ontology
Source: GO:0004518
Synonyms: Not Available
Branch: molecular function
Genes: neil3 (Dre)

lyase activity

Gene Ontology
Source: GO:0016829
Synonyms: Not Available
Branch: molecular function
Genes: neil3 (Dre)...NEIL3 (Hsa)

endonuclease activity

Gene Ontology
Source: GO:0004519
Synonyms: Not Available
Branch: molecular function
Genes: neil3 (Dre)

DNA repair

Gene Ontology
Source: GO:0006281
Synonyms: Not Available
Branch: biological process
Genes: neil3 (Dre)...NEIL3 (Hsa)

catalytic activity

Gene Ontology
Source: GO:0003824
Synonyms:
  • enzyme activity
Branch: molecular function
Genes: neil3 (Dre)

chromosome

Gene Ontology
Source: GO:0005694
Synonyms:
  • chromatid
  • interphase chromosome
Branch: cellular component
Genes: Neil3 (Mmu)...NEIL3 (Hsa)

hepatocellular carcinoma

Disease
Source: DOID:684
Definition: A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver.
Genes: neil3.S (Xla)...Neil3 (Mmu)...NEIL3 (Hsa)...Neil3 (Rno)...neil3 (Dre)

zinc ion binding

Gene Ontology
Source: GO:0008270
Synonyms:
  • Zn binding
  • zinc binding
Branch: molecular function
Genes: Neil3 (Mmu)...NEIL3 (Hsa)...Neil3 (Rno)...neil3 (Dre)

nucleic acid binding

Gene Ontology
Source: GO:0003676
Synonyms:
  • base pairing
Branch: molecular function
Genes: neil3 (Dre)

(GRCh38)4:177310010C>T

(Homo sapiens)
Allele/Variant
Source: rs375478163
Genes: NEIL3 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_exon_variant, synonymous_variant
Diseases: Not Available
Variant Name: (GRCh38)4:177310010C>T
Gene Synonyms: DNA glycosylase/AP lyase Neil3

(GRCh38)4:177339807A>G

(Homo sapiens)
Allele/Variant
Source: NC_000004.12:g.177339807A>G
Genes: NEIL3 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)4:177339807A>G
Gene Synonyms: DNA glycosylase/AP lyase Neil3

(GRCh38)4:177360526A>G

(Homo sapiens)
Allele/Variant
Source: rs746254453
Genes: NEIL3 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant
Diseases: Not Available
Variant Name: (GRCh38)4:177360526A>G
Gene Synonyms: DNA glycosylase/AP lyase Neil3

(GRCh38)4:177341657T>C

(Homo sapiens)
Allele/Variant
Source: rs28618113
Genes: NEIL3 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)4:177341657T>C
Gene Synonyms: DNA glycosylase/AP lyase Neil3

(GRCh38)4:177353418G>C

(Homo sapiens)
Allele/Variant
Source: rs1308309925
Genes: NEIL3 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)4:177353418G>C
Gene Synonyms: DNA glycosylase/AP lyase Neil3

(GRCh38)4:177336362G>A

(Homo sapiens)
Allele/Variant
Source: rs2271102
Genes: NEIL3 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: non_coding_transcript_variant, intron_variant
Diseases: Not Available
Variant Name: (GRCh38)4:177336362G>A
Gene Synonyms: DNA glycosylase/AP lyase Neil3

(GRCh38)4:177310098G>T

(Homo sapiens)
Allele/Variant
Source: rs1734448457
Genes: NEIL3 (Hsa)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: missense_variant, non_coding_transcript_exon_variant
Diseases: Not Available
Variant Name: (GRCh38)4:177310098G>T
Gene Synonyms: DNA glycosylase/AP lyase Neil3