Version: 8.0.0
Date: Tue Jan 28 2025
1,624 results for onecut2

ONECUT2

(Homo sapiens)
Gene
Name: one cut homeobox 2
Synonyms: one cut domain, family member 2, transcription factor ONECUT-2, LOC112267870, one cut domain family member 2, HNF-6-beta, MGC120378, MGC120377, hepatocyte nuclear factor 6-beta, uncharacterized LOC112267870, OC-2, onecut 2, ONECUT-2 homeodomain transcription factor, OC2
Source: HGNC:8139
Biotype: protein coding gene
Symbol: ONECUT2 (Hsa)
Symbol: ONECUT2
Strict Orthology Symbols: onecut2

onecut2

(Danio rerio)
Gene
Name: one cut homeobox 2
Synonyms: si:ch1073-41k10.1
Source: ZFIN:ZDB-GENE-120215-73
Biotype: protein coding gene
Symbol: onecut2 (Dre)
Symbol: onecut2
Automated Gene Synopsis: Orthologous to human ONECUT2 (one cut homeobox 2).
Strict Orthology Symbols: ONECUT2...Onecut2

Onecut2

(Rattus norvegicus)
Gene
Name: one cut homeobox 2
Synonyms: RGD1564677, one cut domain family member 2, LOC307376, similar to transcription factor ONECUT2
Source: RGD:1564677
Biotype: protein coding gene
Symbol: Onecut2 (Rno)
Symbol: Onecut2
Gene Synopsis: Orthologous to human ONECUT2 (one cut homeobox 2); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol
Automated Gene Synopsis: Orthologous to human ONECUT2 (one cut homeobox 2).
Synonyms: similar to transcription factor ONECUT2
Strict Orthology Symbols: onecut2

Onecut2

(Mus musculus)
Gene
Name: one cut domain, family member 2
Synonyms: RGD1564677, OC-2, Oc2
Source: MGI:1891408
Biotype: protein coding gene
Symbol: Onecut2 (Mmu)
Symbol: Onecut2
Automated Gene Synopsis: Orthologous to human ONECUT2 (one cut homeobox 2).
Strict Orthology Symbols: onecut2
Alleles: Onecut2 (Mmu)...Onecut2 (Mmu)...Onecut2 (Mmu)...Onecut2 (Mmu)...Onecut2 (Mmu)

onecut2

(Xenopus tropicalis)
Gene
Name: one cut homeobox 2
Synonyms: onecut2, one cut homeobox 2
Source: Xenbase:XB-GENE-485246
Biotype: gene
Symbol: onecut2 (Xtr)
Symbol: onecut2
Synonyms: onecut2...onecut2...onecut2
Strict Orthology Symbols: onecut2.S...onecut2.L

onecut2.S

(Xenopus laevis)
Gene
Name: one cut homeobox 2
Synonyms: onecut2.S, one cut homeobox 2
Source: Xenbase:XB-GENE-17336189
Biotype: gene
Symbol: onecut2.S (Xla)
Automated Gene Synopsis: Orthologous to human ONECUT2 (one cut homeobox 2).
Strict Orthology Symbols: onecut2
Symbol: onecut2.S

onecut2.L

(Xenopus laevis)
Gene
Name: one cut homeobox 2
Synonyms: one cut homeobox 2, onecut2.L
Source: Xenbase:XB-GENE-17336188
Biotype: gene
Symbol: onecut2.L (Xla)
Automated Gene Synopsis: Orthologous to human ONECUT2 (one cut homeobox 2).
Strict Orthology Symbols: onecut2
Symbol: onecut2.L

Onecut2tm1.2Xmu

(Mus musculus)
Allele/Variant
Source: MGI:7614988
Genes: Onecut2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Onecut2 (Mmu)
Genes: Onecut2 (Mmu)
Symbol: Onecut2tm1.2Xmu

Onecut2tm1Flem

(Mus musculus)
Allele/Variant
Source: MGI:3588425
Genes: Onecut2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Onecut2 (Mmu)
Genes: Onecut2 (Mmu)
Symbol: Onecut2tm1Flem

Onecut2tm1.1Xmu

(Mus musculus)
Allele/Variant
Source: MGI:5661977
Genes: Onecut2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Onecut2 (Mmu)
Genes: Onecut2 (Mmu)
Symbol: Onecut2tm1.1Xmu

Onecut2em1Cya

(Mus musculus)
Allele/Variant
Source: MGI:7585502
Genes: Onecut2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Onecut2 (Mmu)
Genes: Onecut2 (Mmu)
Symbol: Onecut2em1Cya

Onecut2em1Gpt

(Mus musculus)
Allele/Variant
Source: MGI:7303428
Genes: Onecut2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Onecut2 (Mmu)
Genes: Onecut2 (Mmu)
Symbol: Onecut2em1Gpt

Onecut2em3Gpt

(Mus musculus)
Allele/Variant
Source: MGI:7303429
Genes: Onecut2 (Mmu)
Synonyms: Not Available
Variant Type: unreported
Molecular Consequence: Not Available
Diseases: Not Available
Variant Name: Not Available
Symbol: Onecut2 (Mmu)
Genes: Onecut2 (Mmu)
Symbol: Onecut2em3Gpt

Onecut2tm1Flem/Onecut2tm1Flem [background:] involves: 129S1/Sv * 129X1/SvJ * Swiss

(Mus musculus)
Model
Id: MGI:3608974
Synonyms: Not Available
Symbol: Onecut2/Onecut2 [background:] involves: 129S1/Sv * 129X1/SvJ * Swiss (Mmu)
Genes: Onecut2 (Mmu)
Alleles: Onecut2 (Mmu)
Name: Onecut2/Onecut2 [background:] involves: 129S1/Sv * 129X1/SvJ * Swiss

Onecut2tm1Flem/Onecut2tm1Flem Onecut3tm1Jqmn/Onecut3tm1Jqmn [background:] involves: 129S1/Sv * 129X1/SvJ * Swiss

(Mus musculus)
Model
Id: MGI:3711874
Synonyms: Not Available
Symbol: Onecut2/Onecut2 Onecut3/Onecut3 [background:] involves: 129S1/Sv
Genes: Onecut2 (Mmu)
Alleles: Onecut2 (Mmu)
Name: Onecut2/Onecut2 Onecut3/Onecut3 [background:] involves: 129S1/Sv

ceh-48

(Caenorhabditis elegans)
Gene
Name: C. Elegans Homeobox 48
Synonyms: C17H12.9, CELE_C17H12.9
Source: WB:WBGene00015934
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to human ONECUT1 (one cut homeobox 1); ONECUT2 (one cut homeobox 2); and ONECUT3 (one cut
Strict Orthology Symbols: onecut2

onecut

(Drosophila melanogaster)
Gene
Name: onecut
Synonyms: A1, Onecut, CG1922, D-onecut
Source: FB:FBgn0028996
Biotype: protein coding gene
Automated Gene Synopsis: Orthologous to human ONECUT1 (one cut homeobox 1); ONECUT2 (one cut homeobox 2); and ONECUT3 (one cut
Strict Orthology Symbols: onecut2

onecut3

(Xenopus tropicalis)
Gene
Name: one cut homeobox 3
Synonyms: onecut3, one cut homeobox 3
Source: Xenbase:XB-GENE-484505
Biotype: gene
Automated Gene Synopsis: Orthologous to several human genes including ONECUT2 (one cut homeobox 2).
Strict Orthology Symbols: ONECUT2...Onecut2

mesenchymal stem cell migration

Gene Ontology
Source: GO:1905319
Synonyms: Not Available
Branch: biological process
Genes: ONECUT2 (Hsa)...Onecut2 (Rno)...Onecut2 (Mmu)

positive regulation of mesenchymal stem cell migration

Gene Ontology
Source: GO:1905322
Synonyms:
  • activation of mesenchymal stem cell migration
  • up regulation of mesenchymal stem cell migration
Branch: biological process
Genes: ONECUT2 (Hsa)...Onecut2 (Rno)...Onecut2 (Mmu)

Onecut1tm1Flem/Onecut1tm1Flem Onecut2tm1Flem/Onecut2tm1Flem [background:] involves: 129S1/Sv * 129X1/SvJ * Swiss

(Mus musculus)
Model
Id: MGI:3608976
Synonyms: Not Available
Genes: Onecut2 (Mmu)
Alleles: Onecut2 (Mmu)
Name: Onecut1/Onecut1 Onecut2/Onecut2 [background:] involves: 129S1/Sv
Symbol: Onecut1/Onecut1 Onecut2/Onecut2 [background:] involves: 129S1/Sv

regulation of cell-matrix adhesion

Gene Ontology
Source: GO:0001952
Synonyms: Not Available
Branch: biological process
Genes: ONECUT2 (Hsa)...Onecut2 (Mmu)...Onecut2 (Rno)

peripheral nervous system neuron development

Gene Ontology
Source: GO:0048935
Synonyms: Not Available
Branch: biological process
Genes: ONECUT2 (Hsa)...Onecut2 (Mmu)...Onecut2 (Rno)

epithelial cell development

Gene Ontology
Source: GO:0002064
Synonyms: Not Available
Branch: biological process
Genes: ONECUT2 (Hsa)...Onecut2 (Mmu)...Onecut2 (Rno)

Expression data from adult Onecut2 WT and KO animals

(Mus musculus)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by MGI
ID: ArrayExpress:GSE57918
Tags: WT vs. mutant, genotype
Summary: In this study, we examine the consequences of the loss of two related factors, Onecut1 and Onecut2, during mouse retinal development and maturation. To investigate potential phenotypes in Onecut2-KO retinas, microarrays were performed on retinas isolated from mature OC2-KO mice and WT littermates.
Symbol: Expression data from adult Onecut2 WT and KO animals
Name: Expression data from adult Onecut2 WT and KO animals

endocrine pancreas development

Gene Ontology
Source: GO:0031018
Synonyms: Not Available
Branch: biological process
Genes: Onecut2 (Rno)...ONECUT2 (Hsa)...Onecut2 (Mmu)

pancreas development

Gene Ontology
Source: GO:0031016
Synonyms: Not Available
Branch: biological process
Genes: Onecut2 (Rno)...ONECUT2 (Hsa)...Onecut2 (Mmu)

Profiling of chromatin accessibility in fibroblasts, iPSCs, iPSC-derived neurons and cells overexpressing Onecut transcription factors (OC1, OC2, OC3)

(Rattus norvegicus)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE120083
Tags: unclassified
Summary: Remodeling of chromatin accessibility is necessary for successful reprogramming of fibroblasts to neurons. However, it is still not fully known which transcription factors can induce a neuronal chromatin accessibility profile when overexpressed in fibroblasts. To identify such transcription factors, we here used ATAC-sequencing to generate differential chromatin accessibility profiles between human fibroblasts and iNeurons, an in vitro neuronal model system obtained by overexpression of Neurog2 in induced pluripotent stem cells (iPSCs). We found that the ONECUT transcription factor sequence motif was strongly associated with differential chromatin accessibility between iNeurons and fibroblasts. All three ONECUT transcription factors associated with this motif (ONECUT1, ONECUT2 and ONECUT3) induced neuronal morphology and expression of neuronal genes within two days of overexpression in fibroblasts. We observed widespread remodeling of chromatin accessibility; in particular, we found that chromatin regions that contain the ONECUT motif were in- or lowly accessible in fibroblasts and became accessible after the overexpression of ONECUT1, ONECUT2 or ONECUT3. There was substantial overlap with iNeurons, still, many regions that gained accessibility following ONECUT overexpression were not accessible in iNeurons. Our study highlights the potential of ONECUT transcription factors for direct neuronal reprogramming.

Profiling of gene expression using RNA-Seq in fibroblasts, iPSCs, iPSC-derived neurons and cells overexpressing Onecut transcription factors

(Rattus norvegicus)
HTP Dataset Index
High-Throughput (HTP) Dataset Index metadata provided by RGD
ID: GEO:GSE120081
Tags: unclassified
Summary: Remodeling of chromatin accessibility is necessary for successful reprogramming of fibroblasts to neurons. However, it is still not fully known which transcription factors can induce a neuronal chromatin accessibility profile when overexpressed in fibroblasts. To identify such transcription factors, we here used ATAC-sequencing to generate differential chromatin accessibility profiles between human fibroblasts and iNeurons, an in vitro neuronal model system obtained by overexpression of Neurog2 in induced pluripotent stem cells (iPSCs). We found that the ONECUT transcription factor sequence motif was strongly associated with differential chromatin accessibility between iNeurons and fibroblasts. All three ONECUT transcription factors associated with this motif (ONECUT1, ONECUT2 and ONECUT3) induced neuronal morphology and expression of neuronal genes within two days of overexpression in fibroblasts. We observed widespread remodeling of chromatin accessibility; in particular, we found that chromatin regions that contain the ONECUT motif were in- or lowly accessible in fibroblasts and became accessible after the overexpression of ONECUT1, ONECUT2 or ONECUT3. There was substantial overlap with iNeurons, still, many regions that gained accessibility following ONECUT overexpression were not accessible in iNeurons. Our study highlights the potential of ONECUT transcription factors for direct neuronal reprogramming.

negative regulation of transforming growth factor beta receptor signaling pathway

Gene Ontology
Source: GO:0030512
Synonyms:
  • down regulation of transforming growth factor beta receptor signaling pathway
  • down-regulation of transforming growth factor beta receptor signaling pathway
Branch: biological process
Genes: ONECUT2 (Hsa)...Onecut2 (Rno)...Onecut2 (Mmu)

cell fate commitment

Gene Ontology
Source: GO:0045165
Synonyms: Not Available
Branch: biological process
Genes: ONECUT2 (Hsa)...Onecut2 (Rno)...Onecut2 (Mmu)

transforming growth factor beta receptor signaling pathway

Gene Ontology
Source: GO:0007179
Synonyms:
  • TGF-beta receptor signaling pathway
  • TGF-beta receptor signalling pathway
Branch: biological process
Genes: ONECUT2 (Hsa)...Onecut2 (Rno)...Onecut2 (Mmu)

liver development

Gene Ontology
Source: GO:0001889
Synonyms: Not Available
Branch: biological process
Genes: ONECUT2 (Hsa)...Onecut2 (Rno)...Onecut2 (Mmu)

anatomical structure morphogenesis

Gene Ontology
Source: GO:0009653
Synonyms:
  • anatomical structure organization
  • embryogenesis and morphogenesis
Branch: biological process
Genes: ONECUT2 (Hsa)...Onecut2 (Rno)...Onecut2 (Mmu)

actin cytoskeleton

Gene Ontology
Source: GO:0015629
Synonyms: Not Available
Branch: cellular component
Genes: ONECUT2 (Hsa)...Onecut2 (Rno)...Onecut2 (Mmu)

cilium assembly

Gene Ontology
Source: GO:0060271
Synonyms:
  • ciliogenesis
  • cilium biogenesis
Branch: biological process
Genes: ONECUT2 (Hsa)...Onecut2 (Rno)...Onecut2 (Mmu)

cell migration

Gene Ontology
Source: GO:0016477
Synonyms: Not Available
Branch: biological process
Genes: ONECUT2 (Hsa)...Onecut2 (Rno)...Onecut2 (Mmu)

DNA-binding transcription activator activity, RNA polymerase II-specific

Gene Ontology
Source: GO:0001228
Synonyms:
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
  • RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in positive regulation of transcription
Branch: molecular function
Genes: Onecut2 (Mmu)...ONECUT2 (Hsa)...Onecut2 (Rno)

sequence-specific double-stranded DNA binding

Gene Ontology
Source: GO:1990837
Synonyms:
  • sequence-specific dsDNA binding
Branch: molecular function
Genes: Onecut2 (Mmu)...ONECUT2 (Hsa)...Onecut2 (Rno)

DNA-binding transcription factor activity

Gene Ontology
Source: GO:0003700
Synonyms:
  • DNA binding transcription factor activity
  • bacterial-type DNA binding transcription factor activity
Branch: molecular function
Genes: Onecut2 (Mmu)...ONECUT2 (Hsa)...Onecut2 (Rno)

animal organ morphogenesis

Gene Ontology
Source: GO:0009887
Synonyms:
  • histogenesis and organogenesis
Branch: biological process
Genes: ONECUT2 (Hsa)

regulation of transcription by RNA polymerase II

Gene Ontology
Source: GO:0006357
Synonyms:
  • global transcription regulation from Pol II promoter
  • regulation of gene-specific transcription from RNA polymerase II promoter
Branch: biological process
Genes: Onecut2 (Mmu)...ONECUT2 (Hsa)...Onecut2 (Rno)...onecut2 (Dre)

sa12421

(Danio rerio)
Allele/Variant
Source: ZFIN:ZDB-ALT-130411-2154
Genes: onecut2 (Dre)
Synonyms: Not Available
Variant Type: point_mutation
Molecular Consequence: stop_gained
Diseases: Not Available
Variant Name: Not Available
Genes: onecut2 (Dre)

DNA binding

Gene Ontology
Source: GO:0003677
Synonyms:
  • microtubule/chromatin interaction
  • plasmid binding
Branch: molecular function
Genes: ONECUT2 (Hsa)...onecut2 (Dre)

(mRatBN7.2)18:57833109G>A

(Rattus norvegicus)
Allele/Variant
Source: rs3323370843
Genes: Onecut2 (Rno)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: synonymous_variant
Diseases: Not Available
Variant Name: (mRatBN7.2)18:57833109G>A
Gene Synonyms: similar to transcription factor ONECUT2

(mRatBN7.2)18:57836194T>A

(Rattus norvegicus)
Allele/Variant
Source: rs199412233
Genes: Onecut2 (Rno)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (mRatBN7.2)18:57836194T>A
Gene Synonyms: similar to transcription factor ONECUT2

(mRatBN7.2)18:57862293C>T

(Rattus norvegicus)
Allele/Variant
Source: rs3323335235
Genes: Onecut2 (Rno)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (mRatBN7.2)18:57862293C>T
Gene Synonyms: similar to transcription factor ONECUT2

(mRatBN7.2)18:57869849T>C

(Rattus norvegicus)
Allele/Variant
Source: rs196972521
Genes: Onecut2 (Rno)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (mRatBN7.2)18:57869849T>C
Gene Synonyms: similar to transcription factor ONECUT2

(mRatBN7.2)18:57872442A>G

(Rattus norvegicus)
Allele/Variant
Source: NC_051353.1:g.57872442A>G
Genes: Onecut2 (Rno)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (mRatBN7.2)18:57872442A>G
Gene Synonyms: similar to transcription factor ONECUT2

(mRatBN7.2)18:57852191A>C

(Rattus norvegicus)
Allele/Variant
Source: rs107355478
Genes: Onecut2 (Rno)
Synonyms: Not Available
Variant Type: SNP
Molecular Consequence: intron_variant
Diseases: Not Available
Variant Name: (mRatBN7.2)18:57852191A>C
Gene Synonyms: similar to transcription factor ONECUT2